Protein tyrosine phosphatase 1B inhibitors for diabetes (Q34810384)

4 August 2017

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title

Protein tyrosine phosphatase 1B inhibitors for diabetes (English)

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4 August 2017

Theodore O Johnson

1

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4 August 2017

Jacques Ermolieff

series ordinal

2

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4 August 2017

Michael R Jirousek

series ordinal

3

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4 August 2017

publication date

1 September 2002

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Nature Reviews Drug Discovery

4 August 2017

published in

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4 August 2017

volume

1

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4 August 2017

issue

9

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4 August 2017

page(s)

696-709

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Global and societal implications of the diabetes epidemic

4 August 2017

cites work

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Prevalence of impaired glucose tolerance among children and adolescents with marked obesity

31 March 2020

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Childhood obesity and a diabetes epidemic

31 March 2020

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The rising prevalence of diabetes and impaired glucose tolerance: the Australian Diabetes, Obesity and Lifestyle Study

31 March 2020

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The dysmetabolic syndrome

31 March 2020

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Insulin resistance and insulin secretory dysfunction are independent predictors of worsening of glucose tolerance during each stage of type 2 diabetes development

31 March 2020

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Clinical characterization of insulin secretion as the basis for genetic analyses

31 March 2020

1 reference

Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

31 March 2020

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Beyond postprandial hyperglycaemia: metabolic factors associated with cardiovascular disease

31 March 2020

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Unraveling the causes of diabetes

31 March 2020

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Insulin signalling and the regulation of glucose and lipid metabolism

31 March 2020

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Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats

31 March 2020

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Insulin signaling pathways in time and space.

31 March 2020

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Regulated transport of the glucose transporter GLUT4

31 March 2020

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Impaired ('diabetic') insulin signaling and action occur in fat cells long before glucose intolerance--is insulin resistance initiated in the adipose tissue?

31 March 2020

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Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatases

31 March 2020

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Coordinated action of protein tyrosine phosphatases in insulin signal transduction

31 March 2020

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Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein

31 March 2020

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Marked impairment of protein tyrosine phosphatase 1B activity in adipose tissue of obese subjects with and without type 2 diabetes mellitus

31 March 2020

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Genomic characterization of the human and mouse protein tyrosine phosphatase-1B genes.

31 March 2020

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A single nucleotide polymorphism in protein tyrosine phosphatase PTP-1B is associated with protection from diabetes or impaired glucose tolerance in Oji-Cree

31 March 2020

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A variation in 3' UTR of hPTP1B increases specific gene expression and associates with insulin resistance

31 March 2020

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A P387L variant in protein tyrosine phosphatase-1B (PTP-1B) is associated with type 2 diabetes and impaired serine phosphorylation of PTP-1B in vitro

31 March 2020

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Protein-tyrosine phosphatase 1B (PTP1B): a novel therapeutic target for type 2 diabetes mellitus, obesity and related states of insulin resistance

31 March 2020

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Protein tyrosine phosphatase 1B: a new target for the treatment of obesity and associated co-morbidities

31 March 2020

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Protein-tyrosine phosphatase-1B negatively regulates insulin signaling in l6 myocytes and Fao hepatoma cells

31 March 2020

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Protein-tyrosine phosphatases PTP1B and syp are modulators of insulin-stimulated translocation of GLUT4 in transfected rat adipose cells

31 March 2020

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Overexpression of protein-tyrosine phosphatase-1B in adipocytes inhibits insulin-stimulated phosphoinositide 3-kinase activity without altering glucose transport or Akt/Protein kinase B activation

31 March 2020

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Hydrogen peroxide generated during cellular insulin stimulation is integral to activation of the distal insulin signaling cascade in 3T3-L1 adipocytes

31 March 2020

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Insulin stimulates tyrosine phosphorylation and inactivation of protein-tyrosine phosphatase 1B in vivo

31 March 2020

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Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2

31 March 2020

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The mechanism of protein kinase regulation by protein phosphatases

31 March 2020

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Design and characterization of an improved protein tyrosine phosphatase substrate-trapping mutant

31 March 2020

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TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B

31 March 2020

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Imaging sites of receptor dephosphorylation by PTP1B on the surface of the endoplasmic reticulum

31 March 2020

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31 March 2020

A pit stop at the ER.

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Interaction of protein tyrosine phosphatase (PTP) 1B with its substrates is influenced by two distinct binding domains

31 March 2020

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Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

31 March 2020

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Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice

31 March 2020

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PTP1B regulates leptin signal transduction in vivo

31 March 2020

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Protein tyrosine phosphatase 1B: a potential leptin resistance factor of obesity

31 March 2020

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Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B.

31 March 2020

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PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice

31 March 2020

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Crystal structure of human protein tyrosine phosphatase 1B

31 March 2020

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Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B

31 March 2020

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Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics

31 March 2020

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Visualization of the cysteinyl-phosphate intermediate of a protein-tyrosine phosphatase by x-ray crystallography

31 March 2020

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Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design

31 March 2020

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Discovering high-affinity ligands for proteins

31 March 2020

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Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B

31 March 2020

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The YRD motif is a major determinant of substrate and inhibitor specificity in T-cell protein-tyrosine phosphatase

31 March 2020

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Residue 259 is a key determinant of substrate specificity of protein-tyrosine phosphatases 1B and alpha

31 March 2020

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Steric hindrance as a basis for structure-based design of selective inhibitors of protein-tyrosine phosphatases

31 March 2020

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Structure determination of T cell protein-tyrosine phosphatase

31 March 2020

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Murine embryonic fibroblasts lacking TC-PTP display delayed G1 phase through defective NF-kappaB activation

31 March 2020

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Impaired bone marrow microenvironment and immune function in T cell protein tyrosine phosphatase-deficient mice

31 March 2020

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Potent Inhibition of Insulin Receptor Dephosphorylation by a Hexamer Peptide Containing the Phosphotyrosyl Mimetic F2Pmp

31 March 2020

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Small molecule interactions with protein-tyrosine phosphatase PTP1B and their use in inhibitor design

31 March 2020

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Potent and highly selective inhibitors of the protein tyrosine phosphatase 1B

31 March 2020

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Structure of protein tyrosine phosphatase 1B in complex with inhibitors bearing two phosphotyrosine mimetics

31 March 2020

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Acquisition of a specific and potent PTP1B inhibitor from a novel combinatorial library and screening procedure

31 March 2020

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Small molecule peptidomimetics containing a novel phosphotyrosine bioisostere inhibit protein tyrosine phosphatase 1B and augment insulin action

31 March 2020

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Synthesis and biological activity of a novel class of small molecular weight peptidomimetic competitive inhibitors of protein tyrosine phosphatase 1B

31 March 2020

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Investigation of potential bioisosteric replacements for the carboxyl groups of peptidomimetic inhibitors of protein tyrosine phosphatase 1B: identification of a tetrazole-containing inhibitor with cellular activity

31 March 2020

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2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases

31 March 2020

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PTP1B inhibition and antihyperglycemic activity in the ob/ob mouse model of novel 11-arylbenzo[b]naphtho[2,3-d]furans and 11-arylbenzo[b]naphtho[2,3-d]thiophenes

31 March 2020

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A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

31 March 2020

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Molecular docking and high-throughput screening for novel inhibitors of protein tyrosine phosphatase-1B.

31 March 2020

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5 Theoretical and practical aspects of proteinase inhibition kinetics

31 March 2020

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Suramin is an active site-directed, reversible, and tight-binding inhibitor of protein-tyrosine phosphatases

31 March 2020

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Enhanced sensitivity of insulin-resistant adipocytes to vanadate is associated with oxidative stress and decreased reduction of vanadate (+5) to vanadyl (+4).

31 March 2020

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Mechanism of inhibition of protein-tyrosine phosphatases by vanadate and pervanadate

31 March 2020

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Interaction of trace levels of vanadium(IV) and vanadium(V) in biological systems

31 March 2020

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

31 March 2020

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Polar molecular surface properties predict the intestinal absorption of drugs in humans.

31 March 2020

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Molecular properties that influence the oral bioavailability of drug candidates

31 March 2020

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The Finnish Diabetes Prevention Study.

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD895

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4 August 2017

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