Hammerhead ribozymes for target validation (Q34837666)

4 August 2017

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title

Hammerhead ribozymes for target validation (English)

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4 August 2017

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John Goodchild

1

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4 August 2017

language of work or name

English

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publication date

1 April 2002

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Expert Opinion on Therapeutic Targets

4 August 2017

published in

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4 August 2017

volume

6

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4 August 2017

issue

2

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4 August 2017

page(s)

235-247

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Ribozyme structures and mechanisms

4 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Implications of ribozyme kinetics for targeting the cleavage of specific RNA molecules in vivo: more isn't always better

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Target sequence-specific inhibition of HIV-1 replication by ribozymes directed to tat RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Identifying ribozyme-accessible sites using NUH triplet-targeting gapmers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Antisense oligonucleotides selected by hybridisation to scanning arrays are effective reagents in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Antisense RNA gene therapy for studying and modulating biological processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Downregulation of the CCR5 beta-chemokine receptor and inhibition of HIV-1 infection by stable VA1-ribozyme chimeric transcripts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Tethering ribozymes to a retroviral packaging signal for destruction of viral RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Relationships between the activities in vitro and in vivo of various kinds of ribozyme and their intracellular localization in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Significantly higher activity of a cytoplasmic hammerhead ribozyme than a corresponding nuclear counterpart: engineered tRNAs with an extended 3' end can be exported efficiently and specifically to the cytoplasm in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Ribozyme-mediated inhibition of HIV 1 suggests nucleolar trafficking of HIV-1 RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Effective reversal of a transformed phenotype by retrovirus-mediated transfer of a ribozyme directed against mutant N-ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Growth inhibition by a triple ribozyme targeted to repetitive B2 transcripts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Multitarget-ribozyme directed to cleave at up to nine highly conserved HIV-1 env RNA regions inhibits HIV-1 replication--potential effectiveness against most presently sequenced HIV-1 isolates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

A three-nucleotide helix I is sufficient for full activity of a hammerhead ribozyme: advantages of an asymmetric design

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Comparison of different ribozymes for efficient and specific cleavage of BCR/ABL related mRNAs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Ribozyme targeting of HIV-1 LTR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Functional NF-IL6/CCAAT enhancer-binding protein is required for tumor necrosis factor alpha-inducible expression of the granulocyte colony-stimulating factor (CSF), but not the granulocyte/macrophage CSF or interleukin 6 gene in human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Ribozymes designed to inhibit transformation of NIH3T3 cells by the activated c-Ha-ras gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Suppression of H-ras-mediated transformation in NIH3T3 cells by a ras ribozyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Suppression of the malignant phenotype of melanoma cells by anti-oncogene ribozymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Ribozyme-mediated inactivation of mutant K-ras oncogene in a colon cancer cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Specific gene suppression by engineered ribozymes in monkey cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Inhibition of fatty acid synthesis by expression of an acetyl-CoA carboxylase-specific ribozyme gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Hammerhead ribozymes against gamma-glutamylcysteine synthetase mRNA down-regulate intracellular glutathione concentration of mouse islet cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Adenoviral delivery of a leukocyte-type 12 lipoxygenase ribozyme inhibits effects of glucose and platelet-derived growth factor in vascular endothelial and smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Ribozyme-mediated inhibition of caspase-3 activity reduces apoptosis induced by 6-hydroxydopamine in PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Adenovirus-mediated transduction of ribozymes abrogates HER-2/neu and pleiotrophin expression and inhibits tumor cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Specific down-regulation of HER-2/neu mediated by a chimeric U6 hammerhead ribozyme results in growth inhibition of human ovarian carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Inhibition of tumor growth by ribozyme-mediated suppression of aberrant epidermal growth factor receptor gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Ribozyme targeting of receptor for advanced glycation end products in mouse mesangial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Ribozyme to human TGF-beta1 mRNA inhibits the proliferation of human vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Ribozyme approach to downregulate vascular endothelial growth factor (VEGF) 189 expression in non-small cell lung cancer (NSCLC).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Characterization of anti-CCR5 ribozyme-transduced CD34+ hematopoietic progenitor cells in vitro and in a SCID-hu mouse model in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Adenovirus-encoded hammerhead ribozyme to Bcl-2 inhibits neointimal hyperplasia and induces vascular smooth muscle cell apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

A novel allosterically trans-activated ribozyme, the maxizyme, with exceptional specificity in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Ribozyme mediated degradation of beta-amyloid peptide precursor mRNA in COS-7 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Elimination of endogenous aberrant kappa chain transcripts from sp2/0-derived hybridoma cells by specific ribozyme cleavage: utility in genetic therapy of HIV-1 infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Osteopontin (OPN) may facilitate metastasis by protecting cells from macrophage NO-mediated cytotoxicity: evidence from cell lines down-regulated for OPN expression by a targeted ribozyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Ribozymes cleave the AML1/MTG8 fusion transcript and inhibit proliferation of leukemic cells with t(8;21).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Enzymatic and antisense effects of a specific anti-Ki-ras ribozyme in vitro and in cell culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Ribozyme-mediated suppression of the G protein gamma7 subunit suggests a role in hormone regulation of adenylylcyclase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Inhibition of vascular smooth muscle cell proliferation by DNA-RNA chimeric hammerhead ribozyme targeting to rat platelet-derived growth factor A-chain mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Anti-tumorigenic effect of a K-ras ribozyme against human lung cancer cell line heterotransplants in nude mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Bioactivity of anti-angiogenic ribozymes targeting Flt-1 and KDR mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Reduced beta 2-microglobulin mRNA levels in transgenic mice expressing a designed hammerhead ribozyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Generating loss-of-function phenotypes of the fushi tarazu gene with a targeted ribozyme in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Anti-beta s-ribozyme reduces beta s mRNA levels in transgenic mice: potential application to the gene therapy of sickle cell anemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Attenuation of white gene expression in transgenic Drosophila melanogaster: Possible role of a catalytic antisense RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

A nuclease-resistant protein kinase C alpha ribozyme blocks glioma cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

RNA interference: listening to the sound of silence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Frontiers in chemical genetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Antisense oligonucleotides: promise and reality.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

The experimental use of antisense oligonucleotides: a guide for the perplexed

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

The mononucleotide-dependent, nonantisense mechanism of action of phosphodiester and phosphorothioate oligonucleotides depends upon the activity of an ecto-5'-nucleotidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

From bugs to drugs: therapeutic immunomodulation with oligodeoxynucleotides containing CpG sequences from bacterial DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Phosphoramidate oligonucleotides as potent antisense molecules in cells and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

Allosterically controllable maxizymes cleave mRNA with high efficiency and specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.235

21 January 2018

Identifiers

DOI

10.1517/14728222.6.2.235

1 reference

release_epcknx564bagdhphou3zb7oi6u

4 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/epcknx564bagdhphou3zb7oi6u

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference