Proline oxidase functions as a mitochondrial tumor suppressor in human cancers (Q34872984)

5 August 2017

title

Proline oxidase functions as a mitochondrial tumor suppressor in human cancers (English)

1 reference

5 August 2017

Yongmin Liu

1

1 reference

5 August 2017

Gregory L Borchert

2

1 reference

5 August 2017

Steven P Donald

3

1 reference

5 August 2017

Bhalchandra A Diwan

4

1 reference

5 August 2017

Miriam Anver

5

1 reference

5 August 2017

James M Phang

6

1 reference

5 August 2017

language of work or name

English

0 references

publication date

4 August 2009

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5 August 2017

1 reference

5 August 2017

volume

69

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5 August 2017

issue

16

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5 August 2017

page(s)

6414-6422

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The metabolism of proline as microenvironmental stress substrate

5 August 2017

cites work

1 reference

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Proline oxidase, a p53-induced gene, targets COX-2/PGE2 signaling to induce apoptosis and inhibit tumor growth in colorectal cancers.

8 July 2018

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Gadd45 in stress signaling

8 July 2018

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A novel function for hydroxyproline oxidase in apoptosis through generation of reactive oxygen species

8 July 2018

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Targeting mitochondria in the treatment of human cancer: a coordinated attack against cancer cell energy metabolism and signalling

8 July 2018

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Hydroxylation of hypoxia-inducible transcription factors and chemical compounds targeting the HIF-alpha hydroxylases

8 July 2018

1 reference

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p53: new roles in metabolism

8 July 2018

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Hypoxia signalling controls metabolic demand

8 July 2018

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Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF.

8 July 2018

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Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates

8 July 2018

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Tumor metabolism: new opportunities for cancer therapy

8 July 2018

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Overexpression of proline oxidase induces proline-dependent and mitochondria-mediated apoptosis.

8 July 2018

1 reference

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8 July 2018

Oxygen-sensing in tumors

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Oxidative metabolism in cancer growth

8 July 2018

1 reference

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Control of the G2/M transition

8 July 2018

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Proline oxidase activates both intrinsic and extrinsic pathways for apoptosis: the role of ROS/superoxides, NFAT and MEK/ERK signaling

8 July 2018

1 reference

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Mitochondrial tumour suppressors: a genetic and biochemical update

8 July 2018

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Role of GADD34 in modulation of cisplatin cytotoxicity

8 July 2018

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Alpha-ketoglutarate dehydrogenase: a target and generator of oxidative stress

8 July 2018

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Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1.

8 July 2018

1 reference

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Tumor suppressor genetics

8 July 2018

1 reference

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No evidence of INI1hSNF5 (SMARCB1) and PARVG point mutations in oligodendroglial neoplasms

8 July 2018

1 reference

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The p53-induced gene-6 (proline oxidase) mediates apoptosis through a calcineurin-dependent pathway

8 July 2018

1 reference

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MnSOD inhibits proline oxidase-induced apoptosis in colorectal cancer cells.

8 July 2018

1 reference

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Rereplication by depletion of geminin is seen regardless of p53 status and activates a G2/M checkpoint

8 July 2018

1 reference

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Proline oxidase induces apoptosis in tumor cells, and its expression is frequently absent or reduced in renal carcinomas

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287397

N-(4-hydroxyphenyl)retinamide (4-HPR) modulates GADD45 expression in radiosensitive bladder cancer cell lines

8 July 2018

1 reference

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Loss of expression of GADD45 gamma, a growth inhibitory gene, in human pituitary adenomas: implications for tumorigenesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287397

Proline oxidase, encoded by p53-induced gene-6, catalyzes the generation of proline-dependent reactive oxygen species

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287397

Mapping of genetic deletions on the long arm of chromosome 22 in human pancreatic adenocarcinomas

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287397

IL-18-stimulated GADD45 beta required in cytokine-induced, but not TCR-induced, IFN-gamma production.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287397

Functional evidence for an ovarian cancer tumor suppressor gene on chromosome 22 by microcell-mediated chromosome transfer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287397

A GC/MS/MS screening method for multiple organic acidemias from urine specimens

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287397

Novel alternatively spliced isoforms of the neurofibromatosis type 2 tumor suppressor are targeted to the nucleus and cytoplasmic granules

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287397

Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287397

A model for p53-induced apoptosis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287397

The regulatory functions of proline and pyrroline-5-carboxylic acid

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287397

Regulation of proline oxidase activity by lactate

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287397

Loss of heterozygosity on chromosome 22 in human ependymomas

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287397

Absence of hSNF5/INI1 mutation in human lung cancer.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287397

Spectrum of hSNF5/INI1 somatic mutations in human cancer and genotype-phenotype correlations

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287397

Loss of Expression ofGADD45γ, a Growth Inhibitory Gene, in Human Pituitary Adenomas: Implications for Tumorigenesis

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4287397

Malignancy in chromosome 22q11.2 deletion syndrome (DiGeorge syndrome/velocardiofacial syndrome)

9 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19654292

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Catalytic transfer of hydride ions from NADPH to oxygen by the interconversions of proline and delta 1-pyrroline-5-carboxylate

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19654292

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Branched-chain keto-acids and pyruvate in blood: measurement by HPLC with fluorimetric detection and changes in older subjects

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19654292

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/0008-5472.CAN-09-1223

1 reference

5 August 2017

1 reference

5 August 2017

1 reference