The cAMP sensor Epac2 is a direct target of antidiabetic sulfonylurea drugs (Q34994873)

5 August 2017

title

The cAMP sensor Epac2 is a direct target of antidiabetic sulfonylurea drugs (English)

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5 August 2017

Chang-Liang Zhang

1

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5 August 2017

Megumi Katoh

2

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5 August 2017

Tadao Shibasaki

3

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5 August 2017

Kohtaro Minami

4

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5 August 2017

Yasuhiro Sunaga

5

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5 August 2017

Harumi Takahashi

6

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5 August 2017

Norihide Yokoi

7

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5 August 2017

Masahiro Iwasaki

8

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5 August 2017

Takashi Miki

9

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5 August 2017

Susumu Seino

10

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5 August 2017

language of work or name

English

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publication date

1 July 2009

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5 August 2017

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5 August 2017

volume

325

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5 August 2017

issue

5940

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5 August 2017

page(s)

607-610

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Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

5 August 2017

cites work

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https://api.crossref.org/works/10.1126%2FSCIENCE.1172256

A family of cAMP-binding proteins that directly activate Rap1

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.1172256

Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1172256

Epac: a new cAMP target and new avenues in cAMP research

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.1172256

Novel single chain cAMP sensors for receptor-induced signal propagation.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.1172256

Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1172256

Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1172256

Interplay of Ca2+ and cAMP signaling in the insulin-secreting MIN6 beta-cell line

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.1172256

cAMP-GEFII is a direct target of cAMP in regulated exocytosis

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.1172256

The effects of mitiglinide (KAD-1229), a new anti-diabetic drug, on ATP-sensitive K+ channels and insulin secretion: comparison with the sulfonylureas and nateglinide

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1172256

Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.1172256

ATP-sensitive potassium channels: a model of heteromultimeric potassium channel/receptor assemblies

21 January 2018

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Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice.

21 January 2018

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Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose

21 January 2018

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Sur1 knockout mice. A model for K(ATP) channel-independent regulation of insulin secretion

21 January 2018

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SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1172256

cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1172256

Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1172256

The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1172256

21 January 2018

Identifiers

DOI

10.1126/SCIENCE.1172256

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5 August 2017

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