Axonal transport, tau protein, and neurodegeneration in Alzheimer's disease (Q34995116)

5 August 2017

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title

Axonal transport, tau protein, and neurodegeneration in Alzheimer's disease (English)

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5 August 2017

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Ilse Dewachter

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Fred van Leuven

series ordinal

3

object named as

Fred Van Leuven

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5 August 2017

Dick Terwel

1

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5 August 2017

Ilse Dewachter

series ordinal

2

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5 August 2017

publication date

1 January 2002

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5 August 2017

published in

NeuroMolecular Medicine

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5 August 2017

volume

2

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5 August 2017

issue

2

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5 August 2017

page(s)

151-165

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Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

5 August 2017

cites work

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12 December 2020

Tau regulates the attachment/detachment but not the speed of motors in microtubule-dependent transport of single vesicles and organelles

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12 December 2020

Processes induced by tau expression in Sf9 cells have an axon-like microtubule organization

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12 December 2020

Site-specific phosphorylation of tau accompanied by activation of mitogen-activated protein kinase (MAPK) in brains of Niemann-Pick type C mice

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12 December 2020

Attenuated neurodegenerative disease phenotype in tau transgenic mouse lacking neurofilaments

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12 December 2020

Neonatal neuronal overexpression of glycogen synthase kinase-3 beta reduces brain size in transgenic mice.

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12 December 2020

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

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12 December 2020

Tau protein function in living cells

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12 December 2020

Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain

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12 December 2020

A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads

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12 December 2020

The development of cell processes induced by tau protein requires phosphorylation of serine 262 and 356 in the repeat domain and is inhibited by phosphorylation in the proline-rich domains

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12 December 2020

The effect of tau antisense oligonucleotides on neurite formation of cultured cerebellar macroneurons.

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12 December 2020

Involvement of mature tau isoforms in the stabilization of neurites in PC12 cells

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12 December 2020

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

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12 December 2020

Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice

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12 December 2020

Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I

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12 December 2020

Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice.

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12 December 2020

The microtubule binding domain of tau protein.

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12 December 2020

Altered microtubule organization in small-calibre axons of mice lacking tau protein

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12 December 2020

Tau domains, phosphorylation, and interactions with microtubules.

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12 December 2020

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

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12 December 2020

Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules.

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12 December 2020

Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.

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12 December 2020

Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state

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12 December 2020

SOD1 mutation is associated with accumulation of neurofilaments in amyotrophic lateral sclerosis.

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12 December 2020

Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord

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12 December 2020

Dephosphorylation of tau protein and Alzheimer paired helical filaments by calcmeurin and phosphatase-2A

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12 December 2020

Coexpression of GSK-3beta corrects phenotypic aberrations of dorsal root ganglion cells, cultured from adult transgenic mice overexpressing human protein tau

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12 December 2020

Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly

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12 December 2020

Differential phosphorylation of tau by cyclic AMP-dependent protein kinase and Ca2+/calmodulin-dependent protein kinase II: metabolic and functional consequences

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12 December 2020

Unhampered prion neuroinvasion despite impaired fast axonal transport in transgenic mice overexpressing four-repeat tau.

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12 December 2020

Immunochemical and biochemical characterization of tau proteins in normal and Alzheimer's disease brains with Alz 50 and Tau-1.

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12 December 2020

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

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12 December 2020

Neuropathological stageing of Alzheimer-related changes

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12 December 2020

Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity

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12 December 2020

Characterization of tau phosphorylation in glycogen synthase kinase-3beta and cyclin dependent kinase-5 activator (p23) transfected cells

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12 December 2020

Aberrant stress response associated with severe hypoglycemia in a transgenic mouse model of Alzheimer's disease

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12 December 2020

Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes

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12 December 2020

Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila.

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12 December 2020

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

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12 December 2020

Elevated transglutaminase-induced bonds in PHF tau in Alzheimer's disease.

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12 December 2020

Immunocytochemical characterization of neurofibrillary tangles in amyotrophic lateral sclerosis and parkinsonism-dementia of Guam

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12 December 2020

Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

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12 December 2020

Casein kinase II preferentially phosphorylates human tau isoforms containing an amino-terminal insert. Identification of threonine 39 as the primary phosphate acceptor.

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12 December 2020

The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer's disease

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12 December 2020

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work

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12 December 2020

Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5

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12 December 2020

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

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12 December 2020

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

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12 December 2020

Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases

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12 December 2020

A portrait of Alzheimer secretases--new features and familiar faces

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12 December 2020

Defective brain microtubule assembly in Alzheimer's disease

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12 December 2020

Aging increased amyloid peptide and caused amyloid plaques in brain of old APP/V717I transgenic mice by a different mechanism than mutant presenilin1

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12 December 2020

Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the london mutant of human APP in neurons.

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12 December 2020

PD98059 prevents neurite degeneration induced by fibrillar beta-amyloid in mature hippocampal neurons

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12 December 2020

Glycosylation of microtubule-associated protein tau: an abnormal posttranslational modification in Alzheimer's disease

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12 December 2020

Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility

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12 December 2020

Structure of tau protein and assembly into paired helical filaments

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12 December 2020

Amyloid diseases: abnormal protein aggregation in neurodegeneration

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12 December 2020

In vivo activation and nuclear translocation of phosphorylated glycogen synthase kinase-3beta in neuronal apoptosis: links to tau phosphorylation.

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12 December 2020

Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein

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12 December 2020

Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau.

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12 December 2020

Tau pathology: a marker of neurodegenerative disorders.

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12 December 2020

Inhibition of neurite polarity by tau antisense oligonucleotides in primary cerebellar neurons

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12 December 2020

Differences in the abilities of human tau isoforms to promote microtubule assembly.

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12 December 2020

4-Hydroxynonenal, a product of lipid peroxidation, inhibits dephosphorylation of the microtubule-associated protein tau.

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12 December 2020

Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments

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12 December 2020

Rapid tyrosine phosphorylation of neuronal proteins including tau and focal adhesion kinase in response to amyloid-beta peptide exposure: involvement of Src family protein kinases.

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12 December 2020

Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress

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12 December 2020

Alzheimer disease hyperphosphorylated tau aggregates hydrophobically

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12 December 2020

Kinesin molecular motors: transport pathways, receptors, and human disease

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12 December 2020

Tau in paired helical filaments is functionally distinct from fetal tau: assembly incompetence of paired helical filament-tau

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12 December 2020

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

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12 December 2020

Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice.

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12 December 2020

Age-dependent induction of congophilic neurofibrillary tau inclusions in tau transgenic mice

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12 December 2020

Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

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12 December 2020

Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila

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12 December 2020

Tau is essential to beta -amyloid-induced neurotoxicity

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12 December 2020

Cognitive deficit and development of motor impairment in a mouse model of Niemann-Pick type C disease

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12 December 2020

Immunohistochemical localization of neurofilament protein in neuronal degenerations.

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12 December 2020

The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain

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12 December 2020

Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease

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12 December 2020

Neuropil threads of Alzheimer's disease show a marked alteration of the normal cytoskeleton

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12 December 2020

Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: a radioimmuno-slot-blot assay for nanograms of the protein

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12 December 2020

Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization

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12 December 2020

Identifiers

DOI

10.1385/NMM:2:2:151

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Dimensions Publication ID

5 August 2017

1052152132

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