Orchestrating the unfolded protein response in health and disease (Q35001604)

5 August 2017

1 reference

title

Orchestrating the unfolded protein response in health and disease (English)

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5 August 2017

Randal J Kaufman

1

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5 August 2017

language of work or name

English

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publication date

1 November 2002

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Journal of Clinical Investigation

5 August 2017

published in

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5 August 2017

volume

110

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5 August 2017

issue

10

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5 August 2017

page(s)

1389-1398

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Rescuing protein conformation: prospects for pharmacological therapy in cystic fibrosis

5 August 2017

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8 July 2018

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8 July 2018

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ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

8 July 2018

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8 July 2018

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The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas

8 July 2018

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8 July 2018

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8 July 2018

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The protein kinase/endoribonuclease IRE1alpha that signals the unfolded protein response has a luminal N-terminal ligand-independent dimerization domain

8 July 2018

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8 July 2018

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IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

8 July 2018

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Molecular pathways of protein synthesis inhibition during brain reperfusion: implications for neuronal survival or death

8 July 2018

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Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein

8 July 2018

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IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

8 July 2018

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Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development

8 July 2018

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XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

8 July 2018

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Targeting of the c-Abl tyrosine kinase to mitochondria in endoplasmic reticulum stress-induced apoptosis

8 July 2018

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8 July 2018

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Plasma cell differentiation requires the transcription factor XBP-1

8 July 2018

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ER quality control: towards an understanding at the molecular level

8 July 2018

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Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation

8 July 2018

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Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response

8 July 2018

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An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

8 July 2018

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Translational control is required for the unfolded protein response and in vivo glucose homeostasis

8 July 2018

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Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

8 July 2018

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The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action

8 July 2018

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Impairment of the ubiquitin-proteasome system by protein aggregation

8 July 2018

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Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways

8 July 2018

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Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals

8 July 2018

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Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress

8 July 2018

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Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model

8 July 2018

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Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice

8 July 2018

1 reference

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ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151822

Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response

8 July 2018

1 reference

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Identification of ERSE-II, a new cis-acting element responsible for the ATF6-dependent mammalian unfolded protein response

8 July 2018

1 reference

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Regulated translation initiation controls stress-induced gene expression in mammalian cells

8 July 2018

1 reference

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The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response

8 July 2018

1 reference

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IRE1 and efferent signaling from the endoplasmic reticulum.

8 July 2018

1 reference

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Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes

8 July 2018

1 reference

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Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151822

ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response

8 July 2018

1 reference

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Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis

8 July 2018

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EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome

8 July 2018

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ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1

8 July 2018

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Tripartite management of unfolded proteins in the endoplasmic reticulum

8 July 2018

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Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation

8 July 2018

1 reference

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mRNA splicing-mediated C-terminal replacement of transcription factor Hac1p is required for efficient activation of the unfolded protein response

8 July 2018

1 reference

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An essential role in liver development for transcription factor XBP-1

8 July 2018

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Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

8 July 2018

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Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

8 July 2018

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A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response

8 July 2018

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Procollagen folding and assembly: the role of endoplasmic reticulum enzymes and molecular chaperones

8 July 2018

1 reference

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Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

8 July 2018

1 reference

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Diverse functions of JNK signaling and c-Jun in stress response and apoptosis

8 July 2018

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Cellular origin of hexokinase in pancreatic islets

8 July 2018

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Targeted disruption of CRE-binding factor TREB5 gene leads to cellular necrosis in cardiac myocytes at the embryonic stage

8 July 2018

1 reference

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Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151822

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

8 July 2018

1 reference

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Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion

8 July 2018

1 reference

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Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151822

Cloning of mammalian Ire1 reveals diversity in the ER stress responses

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151822

A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151822

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

8 July 2018

1 reference

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Involvement of endoplasmic reticulum chaperones in the folding of hepatitis C virus glycoproteins

8 July 2018

1 reference

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Overexpression of Pex15p, a phosphorylated peroxisomal integral membrane protein required for peroxisome assembly in S.cerevisiae, causes proliferation of the endoplasmic reticulum membrane

8 July 2018

1 reference

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Induction of glucose-regulated protein (glucose-regulated protein 78/BiP and glucose-regulated protein 94) and heat shock protein 70 transcripts in the immature rat brain following status epilepticus.

8 July 2018

1 reference

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The basic domain/leucine zipper protein hXBP-1 preferentially binds to and transactivates CRE-like sequences containing an ACGT core

8 July 2018

1 reference

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A lag in intracellular degradation of mutant alpha 1-antitrypsin correlates with the liver disease phenotype in homozygous PiZZ alpha 1-antitrypsin deficiency

8 July 2018

1 reference

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Mammalian stress response: induction of the glucose-regulated protein family

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151822

Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151822

Dietary supplementation with methionine and homocysteine promotes early atherosclerosis but not plaque rupture in ApoE-deficient mice

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151822

Homocysteine thiolactone induces apoptotic DNA damage mediated by increased intracellular hydrogen peroxide and caspase 3 activation in HL-60 cells.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151822

Brain ischemia and reperfusion activates the eukaryotic initiation factor 2alpha kinase, PERK.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151822

Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151822

Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151822

Ultrastructural changes during the enhancement of cellular 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase in a Chinese hamster cell mutant resistant to compactin (ML 236B)

26 October 2018

1 reference

12 December 2020

Inducible membranes in yeast: relation to the unfolded-protein-response pathway

1 reference

12 December 2020

Genetic tailoring of N-linked oligosaccharides: the role of glucose residues in glycoprotein processing of Saccharomyces cerevisiae in vivo

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12 December 2020

Null mutation in IRE1 gene inhibits overproduction of microsomal cytochrome P450Alk1 (CYP 52A3) and proliferation of the endoplasmic reticulum in Saccharomyces cerevisiae

1 reference

12 December 2020

Effect of glucose on initiation and elongation rates in isolated rat pancreatic islets

1 reference

12 December 2020

Translational control of proinsulin synthesis by glucose

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI0216886

1 reference

5 August 2017

1 reference

5 August 2017

1 reference