Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington's disease mice: genome-wide and candidate approaches (Q35034398)

5 August 2017

title

Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington's disease mice: genome-wide and candidate approaches (English)

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5 August 2017

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1 reference

Ricardo Mouro Pinto

1

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Guo-Min Li

object named as

Guo-Min Li

13

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Mark Joseph Daly

15

object named as

Mark J Daly

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5 August 2017

10

Tammy Gillis

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5 August 2017

Ella Dragileva

2

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5 August 2017

Andrew Kirby

3

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5 August 2017

Alejandro Lloret

4

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5 August 2017

Edith Lopez

5

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5 August 2017

Jason St Claire

6

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5 August 2017

Gagan B Panigrahi

7

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5 August 2017

Caixia Hou

8

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5 August 2017

Kim Holloway

9

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5 August 2017

Jolene R Guide

11

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5 August 2017

Paula E Cohen

12

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5 August 2017

Christopher E Pearson

14

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5 August 2017

Vanessa C Wheeler

16

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5 August 2017

publication date

31 October 2013

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5 August 2017

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5 August 2017

volume

9

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5 August 2017

issue

10

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5 August 2017

page(s)

e1003930

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Creative Commons Attribution 4.0 International

5 August 2017

copyright license

start time

31 October 2013

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Stoichiometry of base excision repair proteins correlates with increased somatic CAG instability in striatum over cerebellum in Huntington's disease transgenic mice

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genes

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Triplet repeat mutation length gains correlate with cell-type specific vulnerability in Huntington disease brain

8 July 2018

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8 July 2018

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Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Pms2 is a genetic enhancer of trinucleotide CAG.CTG repeat somatic mosaicism: implications for the mechanism of triplet repeat expansion

8 July 2018

1 reference

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Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset

8 July 2018

1 reference

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A genome scan for modifiers of age at onset in Huntington disease: The HD MAPS study.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3814320

CTG repeat instability and size variation timing in DNA repair-deficient mice

8 July 2018

1 reference

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Mouse models for human DNA mismatch-repair gene defects

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3814320

Meiotic arrest and aneuploidy in MLH3-deficient mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3814320

ATR and ATRIP: partners in checkpoint signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3814320

Differential ATP binding and intrinsic ATP hydrolysis by amino-terminal domains of the yeast Mlh1 and Pms1 proteins

8 July 2018

1 reference

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A new mathematical model for relative quantification in real-time RT-PCR

8 July 2018

1 reference

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Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3814320

Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3814320

Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3814320

Length-dependent gametic CAG repeat instability in the Huntington's disease knock-in mouse

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3814320

The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutations

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3814320

Role of Saccharomyces cerevisiae Msh2 and Msh3 repair proteins in double-strand break-induced recombination

8 July 2018

1 reference

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Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1).

8 July 2018

1 reference

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Meiotic pachytene arrest in MLH1-deficient mice

8 July 2018

1 reference

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

8 July 2018

1 reference

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Trinucleotide repeat length instability and age of onset in Huntington's disease

8 July 2018

1 reference

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Somatic and gonadal mosaicism of the Huntington disease gene CAG repeat in brain and sperm.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3814320

Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs

8 July 2018

1 reference

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Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results

8 July 2018

1 reference

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MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations

8 July 2018

1 reference

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Mapping mendelian factors underlying quantitative traits using RFLP linkage maps

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3814320

Dramatic tissue-specific mutation length increases are an early molecular event in Huntington disease pathogenesis

8 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003930

Inherited CAG.CTG allele length is a major modifier of somatic mutation length variability in Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003930

Somatic expansion of the (CAG)n repeat in Huntington disease brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003930

Genetic background modifies nuclear mutant huntingtin accumulation and HD CAG repeat instability in Huntington's disease knock-in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003930

Mismatch repair gene Msh2 modifies the timing of early disease in Hdh(Q111) striatum

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003930

Somatic expansion behaviour of the (CTG)n repeat in myotonic dystrophy knock-in mice is differentially affected by Msh3 and Msh6 mismatch-repair proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003930

Msh3 is a limiting factor in the formation of intergenerational CTG expansions in DM1 transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003930

Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003930

Endonucleolytic function of MutLalpha in human mismatch repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003930

Instability of highly expanded CAG repeats in mice transgenic for the Huntington's disease mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003930

Functional analysis of hMLH1 variants and HNPCC-related mutations using a human expression system

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003930

Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003930

Aberrant protein expression and frequent allelic loss of MSH3 in colorectal cancer with low-level microsatellite instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003930

Resolution of quantitative traits into Mendelian factors by using a complete linkage map of restriction fragment length polymorphisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003930

Human MSH2 binds to trinucleotide repeat DNA structures associated with neurodegenerative diseases

21 January 2018

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12 December 2020

Noncanonical Mismatch Repair as a Source of Genomic Instability in Human Cells

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12 December 2020

Tissue-specific mismatch repair protein expression: MSH3 is higher than MSH6 in multiple mouse tissues

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12 December 2020

Functional analysis of human MLH1 variants using yeast and in vitro mismatch repair assays

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12 December 2020

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10.1371/JOURNAL.PGEN.1003930

Identifiers

DOI

1 reference

5 August 2017

1 reference

5 August 2017

1 reference