The degradation of amyloid beta as a therapeutic strategy in Alzheimer's disease and cerebrovascular amyloidoses (Q35039021)

5 August 2017

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title

The degradation of amyloid beta as a therapeutic strategy in Alzheimer's disease and cerebrovascular amyloidoses (English)

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5 August 2017

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Laura Morelli

1

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5 August 2017

Ramiro Llovera

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2

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5 August 2017

Sandra Ibendahl

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3

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5 August 2017

Eduardo M Castaño

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4

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5 August 2017

publication date

1 November 2002

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5 August 2017

published in

Neurochemical Research

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5 August 2017

volume

27

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5 August 2017

issue

11

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5 August 2017

page(s)

1387-1399

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Interaction of apolipoprotein J-amyloid beta-peptide complex with low density lipoprotein receptor-related protein-2/megalin. A mechanism to prevent pathological accumulation of amyloid beta-peptide

5 August 2017

cites work

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12 December 2020

Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains.

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12 December 2020

The length of amyloid-beta in hereditary cerebral hemorrhage with amyloidosis, Dutch type. Implications for the role of amyloid-beta 1-42 in Alzheimer's disease

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12 December 2020

Familial Alzheimer's disease-linked mutations at Val717 of amyloid precursor protein are specific for the increased secretion of A beta 42(43).

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12 December 2020

Long-term doxycycline-controlled expression of human tyrosine hydroxylase after direct adenovirus-mediated gene transfer to a rat model of Parkinson's disease.

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12 December 2020

Matrix metalloproteinase-9 (MMP-9) is synthesized in neurons of the human hippocampus and is capable of degrading the amyloid-beta peptide (1-40).

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12 December 2020

Antibodies to the beta-amyloid peptide cross-react with conformational epitopes in human fibrinogen subunits from peripheral blood

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12 December 2020

Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer disease

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12 December 2020

Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: Evidence for early up-regulation of the endosomal-lysosomal system

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12 December 2020

In vitro stimulation of tissue-type plasminogen activator by Alzheimer amyloid β-peptide analogues

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12 December 2020

Mechanisms of beta-amyloid neurotoxicity: perspectives of pharmacotherapy

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12 December 2020

Calpain inhibitor I increases beta-amyloid peptide production by inhibiting the degradation of the substrate of gamma-secretase. Evidence that substrate availability limits beta-amyloid peptide production

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12 December 2020

Human amyloidosis, Alzheimer disease and related disorders.

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12 December 2020

Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease.

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12 December 2020

Co-localization of beta/A4 and cystatin C in cortical blood vessels in Dutch, but not in Icelandic hereditary cerebral hemorrhage with amyloidosis

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12 December 2020

Angiotensin-converting enzyme genotype is associated with Alzheimer disease in the Japanese population

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12 December 2020

Alterations of peptide metabolism and neuropeptidase activity in senile dementia of the Alzheimer's type

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12 December 2020

A monoclonal antibody to common acute lymphoblastic leukemia antigen (neutral endopeptidase) immunostains senile plaques in the brains of patients with Alzheimer's disease

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12 December 2020

The rat insulin-degrading enzyme. Molecular cloning and characterization of tissue-specific transcripts

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12 December 2020

Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme

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12 December 2020

A polymorphism in the cystatin C gene is a novel risk factor for late-onset Alzheimer's disease.

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12 December 2020

Plasma levels of amyloid beta proteins Abeta1-40 and Abeta1-42(43) are elevated in Down's syndrome

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12 December 2020

Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway.

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12 December 2020

Insulin-degrading enzyme is differentially expressed and developmentally regulated in various rat tissues

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12 December 2020

Apolipoprotein E epsilon 4 and fatal cerebral amyloid angiopathy associated with dementia pugilistica

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12 December 2020

Cathepsin D is involved in the clearance of Alzheimer's beta-amyloid protein

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12 December 2020

Genetic polymorphism of cathepsin D is strongly associated with the risk for developing sporadic Alzheimer's disease.

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12 December 2020

alpha2-macroglobulin in late-onset Alzheimer's disease

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12 December 2020

Localization of tissue inhibitor of matrix metalloproteinases in Alzheimer's disease and normal brain.

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12 December 2020

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

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12 December 2020

The serpin-enzyme complex receptor recognizes soluble, nontoxic amyloid-beta peptide but not aggregated, cytotoxic amyloid-beta peptide

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12 December 2020

Novel Leu723Pro amyloid precursor protein mutation increases amyloid beta42(43) peptide levels and induces apoptosis

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12 December 2020

Increase in cathepsin D activity in rat brain in aging

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12 December 2020

Effect of cytokines, dexamethasone and the A/T-signal peptide polymorphism on the expression of alpha(1)-antichymotrypsin in astrocytes: significance for Alzheimer's disease

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12 December 2020

Proteolysis of A beta peptide from Alzheimer disease brain by gelatinase A.

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12 December 2020

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

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12 December 2020

Susceptibility locus for Alzheimer's disease on chromosome 10.

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12 December 2020

Novel amyloid precursor protein gene mutation (codon 665Asp) in a patient with late-onset Alzheimer's disease

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12 December 2020

Alzheimer's risk associated with human apolipoprotein E, alpha-2 macroglobulin and lipoprotein receptor related protein polymorphisms: absence of genetic interactions, and modulation by gender.

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12 December 2020

Elevation of cystatin C in susceptible neurons in Alzheimer's disease

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12 December 2020

Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme

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12 December 2020

Partial purification and characterization of insulin protease and its intracellular inhibitor from rat liver

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12 December 2020

Protein kinase C epsilon suppresses Abeta production and promotes activation of alpha-secretase.

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12 December 2020

Increased production of matrix metalloproteinases in enriched astrocyte and mixed hippocampal cultures treated with beta-amyloid peptides.

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12 December 2020

The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

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12 December 2020

Neuritic plaque amyloid in Alzheimer's disease is highly racemized

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12 December 2020

Amyloid plaque core protein in Alzheimer disease and Down syndrome

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12 December 2020

Novel polymorphism in the A4 region of the amyloid precursor protein gene in a patient without Alzheimer's disease.

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12 December 2020

Tissue inhibitors of metalloproteinases: evolution, structure and function

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12 December 2020

Alpha-1-antichymotrypsin promotes beta-sheet amyloid plaque deposition in a transgenic mouse model of Alzheimer's disease.

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12 December 2020

Proteoglycan-mediated inhibition of A beta proteolysis. A potential cause of senile plaque accumulation.

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12 December 2020

Recombinant proteins for neurodegenerative diseases: the delivery issue

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12 December 2020

Abnormal distribution of cathepsin proteinases and endogenous inhibitors (cystatins) in the hippocampus of patients with Alzheimer's disease, parkinsonism-dementia complex on Guam, and senile dementia and in the aged

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12 December 2020

In vitro studies of amyloid beta-protein fibril assembly and toxicity provide clues to the aetiology of Flemish variant (Ala692-->Gly) Alzheimer's disease

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12 December 2020

Insulysin hydrolyzes amyloid beta peptides to products that are neither neurotoxic nor deposit on amyloid plaques.

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12 December 2020

Comparative analysis of amyloid-beta chemical structure and amyloid plaque morphology of transgenic mouse and Alzheimer's disease brains

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12 December 2020

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

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12 December 2020

Evidence for genetic linkage of Alzheimer's disease to chromosome 10q

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12 December 2020

Amyloidogenic determinant as a substrate recognition motif of insulin-degrading enzyme

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12 December 2020

The ACE gene and Alzheimer's disease susceptibility

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12 December 2020

Neurotrophic factors regulate cathepsin S in macrophages and microglia: A role in the degradation of myelin basic protein and amyloid beta peptide

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12 December 2020

Accumulation of inactive cathepsin D in old rats

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12 December 2020

Differential effects of proteases involved in intracellular degradation of amyloid beta-protein between detergent-soluble and -insoluble pools in CHO-695 cells

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12 December 2020

Protease inhibitor coinfusion with amyloid beta-protein results in enhanced deposition and toxicity in rat brain.

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12 December 2020

Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor

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12 December 2020

Enhanced pathologic properties of Dutch-type mutant amyloid beta-protein

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12 December 2020

Affinity purification of insulin-degrading enzyme and its endogenous inhibitor from rat liver

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12 December 2020

Aberrant presenilin-1 expression downregulates LDL receptor-related protein (LRP): is LRP central to Alzheimer's disease pathogenesis?

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12 December 2020

Brain amyloid in normal aging and cerebral amyloid angiopathy is antigenically related to Alzheimer's disease beta-protein.

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12 December 2020

Brain plasmin enhances APP alpha-cleavage and Abeta degradation and is reduced in Alzheimer's disease brains

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12 December 2020

Insulin-degrading enzyme

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12 December 2020

Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme

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12 December 2020

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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12 December 2020

A beta-amyloid peptide variant related with familial Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis is poorly eliminated by cathepsin D.

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12 December 2020

Differential accumulation of soluble amyloid beta peptides 1-40 and 1-42 in human monocytic and neuroblastoma cell lines. Implications for cerebral amyloidogenesis

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12 December 2020

Regulation by retinoic acid of insulin-degrading enzyme and of a related endoprotease in human neuroblastoma cell lines

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12 December 2020

Fibrillogenesis in Alzheimer's disease of amyloid beta peptides and apolipoprotein E.

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12 December 2020

Metalloendopeptidase EC 3.4.24.15 is necessary for Alzheimer's amyloid-beta peptide degradation

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12 December 2020

Flemish and Dutch mutations in amyloid beta precursor protein have different effects on amyloid beta secretion

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12 December 2020

Neutral endopeptidase can hydrolyze beta-amyloid(1-40) but shows no effect on beta-amyloid precursor protein metabolism

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12 December 2020

Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation

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12 December 2020

Activated isoforms of MMP-2 are induced in U87 human glioma cells in response to beta-amyloid peptide

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12 December 2020

Altered beta-APP metabolism after head injury and its relationship to the aetiology of Alzheimer's disease.

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12 December 2020

Degradation of amyloid beta-protein by a serine protease-alpha2-macroglobulin complex

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12 December 2020

Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

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12 December 2020

A portrait of Alzheimer secretases--new features and familiar faces

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12 December 2020

Identification and characterization of two androgen response regions in the human neutral endopeptidase gene

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12 December 2020

Metabolic regulation of brain Abeta by neprilysin

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12 December 2020

An unusual active site identified in a family of zinc metalloendopeptidases

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12 December 2020

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12 December 2020

Codeposition of cystatin C with amyloid-beta protein in the brain of Alzheimer disease patients

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12 December 2020

Antibody-mediated phagocytosis of the amyloid beta-peptide in microglia is differentially modulated by C1q.

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12 December 2020

"Enkephalinase", a newly characterised dipeptidyl carboxypeptidase: properties and possible role in enkephalinergic transmission

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12 December 2020

Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition

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12 December 2020

Delivery of peptides and proteins through the blood-brain barrier

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12 December 2020

Astroglial expression of human alpha(1)-antichymotrypsin enhances alzheimer-like pathology in amyloid protein precursor transgenic mice

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12 December 2020

Expression and function of the low density lipoprotein receptor-related protein (LRP) in mammalian central neurons.

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12 December 2020

Insulin-degrading enzyme: embarking on amyloid destruction.

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12 December 2020

More missense in amyloid gene.

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12 December 2020

Therapeutic benefit of polyamine-modified catalase as a scavenger of hydrogen peroxide and nitric oxide in familial amyotrophic lateral sclerosis transgenics

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12 December 2020

Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease

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12 December 2020

Families of zinc metalloproteases.

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12 December 2020

Beta-amyloid increases cathepsin D levels in hippocampus

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12 December 2020

Substitutions at codon 22 of Alzheimer's abeta peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells.

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12 December 2020

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

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12 December 2020

Degradation of Alzheimer's beta-amyloid protein by human and rat brain peptidases: involvement of insulin-degrading enzyme

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12 December 2020

Alpha2-macroglobulin complexes with and mediates the endocytosis of beta-amyloid peptide via cell surface low-density lipoprotein receptor-related protein.

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12 December 2020

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

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12 December 2020

Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling.

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12 December 2020

Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees

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12 December 2020

Plasminogen activator inhibitor-1 in the cerebrospinal fluid as an index of neurological disease.

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12 December 2020

Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease

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12 December 2020

A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

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12 December 2020

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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12 December 2020

Characterization of the promoter region of the rat neprilysin gene

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12 December 2020

The neprilysin (NEP) family of zinc metalloendopeptidases: genomics and function

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12 December 2020

Genetic association of a cystatin C gene polymorphism with late-onset Alzheimer disease.

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12 December 2020

Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin

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12 December 2020

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

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12 December 2020

Multifunctional potential of the plasminogen activation system in tumor invasion and metastasis (review)

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12 December 2020

Mechanism of cell surface activation of 72-kDa type IV collagenase. Isolation of the activated form of the membrane metalloprotease

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12 December 2020

Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides

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12 December 2020

Isolation and identification of an endogenous inhibitor of enkephalin-degrading enzymes from bovine spinal cord

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12 December 2020

Degradation of Alzheimer's beta-amyloid protein by human cathepsin D.

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12 December 2020

Elements of the fibrinolytic system

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12 December 2020

Matrix metalloproteinases and diseases of the CNS.

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12 December 2020

Pathogenic effects of D23N Iowa mutant amyloid beta -protein

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12 December 2020

Mammalian membrane metallopeptidases: NEP, ECE, KELL, and PEX.

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12 December 2020

Amyloid-beta-induced degeneration of human brain pericytes is dependent on the apolipoprotein E genotype.

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12 December 2020

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12 December 2020

Apolipoprotein E epsilon 4 is associated with the presence and earlier onset of hemorrhage in cerebral amyloid angiopathy

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12 December 2020

Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons

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12 December 2020

A metalloproteinase inhibitor domain in Alzheimer amyloid protein precursor.

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12 December 2020

Comparison of the structure and expression of the human and rat neprilysin (endopeptidase 24.11)-encoding genes

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12 December 2020

Racemization of Asp23 residue affects the aggregation properties of Alzheimer amyloid beta protein analogues.

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12 December 2020

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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12 December 2020

Angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide (A beta ); retards A beta aggregation, deposition, fibril formation; and inhibits cytotoxicity

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12 December 2020

Peptides homologous to the amyloid protein of Alzheimer's disease containing a glutamine for glutamic acid substitution have accelerated amyloid fibril formation.

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12 December 2020

Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease

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12 December 2020

Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of beta-amyloid peptide

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12 December 2020

Intracerebral hemorrhage after fibrinolytic therapy for acute myocardial infarction

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12 December 2020

The plasmin system is induced by and degrades amyloid-beta aggregates

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12 December 2020

Plasmin cleavage of the amyloid beta-protein: alteration of secondary structure and stimulation of tissue plasminogen activator activity

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12 December 2020

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

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12 December 2020

Identifiers

DOI

10.1023/A:1021679817756

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Dimensions Publication ID

5 August 2017

1031885858

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