Cytokine therapeutics: lessons from interferon alpha (Q35033232)

5 August 2017

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title

Cytokine therapeutics: lessons from interferon alpha (English)

1 reference

5 August 2017

J U Gutterman

1

1 reference

5 August 2017

language of work or name

English

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publication date

1 February 1994

1 reference

Proceedings of the National Academy of Sciences of the United States of America

5 August 2017

published in

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5 August 2017

volume

91

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5 August 2017

issue

4

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5 August 2017

page(s)

1198-1205

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Antiviral therapy of hepatitis C--present and future

5 August 2017

cites work

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8 July 2018

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8 July 2018

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BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein

8 July 2018

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8 July 2018

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Type-I interferons are potent inhibitors of interleukin-8 production in hematopoietic and bone marrow stromal cells

8 July 2018

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Trying on a new pair of SH2s

8 July 2018

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New intracellular targets for therapeutic drug design

8 July 2018

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Role of growth factors and their receptors in the development and progression of melanoma

8 July 2018

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Interferon alpha induces protein kinase C-epsilon (PKC-epsilon) gene expression and a 4.7-kb PKC-epsilon-related transcript

8 July 2018

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8 July 2018

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Genes that can antagonize tumor development

8 July 2018

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Regulation of gene expression and cell function by extracellular matrix.

8 July 2018

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Molecular genetic aspects of human cancers: the 1993 Frank Rose Lecture

8 July 2018

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8 July 2018

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Submembranous junctional plaque proteins include potential tumor suppressor molecules

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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An antiviral soluble form of the LDL receptor induced by interferon

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Reverse transformation, genome exposure, and cancer.

8 July 2018

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Compartmentalization of T lymphocytes to the site of disease: intrahepatic CD4+ T cells specific for the protein NS4 of hepatitis C virus in patients with chronic hepatitis C

8 July 2018

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Translation factors as effectors of cell growth and tumorigenesis

8 July 2018

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Biological strategies for the selective manipulation of normal and leukemic stem cells

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Cutaneous lymphoproliferation and lymphomas in interleukin 7 transgenic mice

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Recombinant Leukocyte A Interferon: Pharmacokinetics, Single-Dose Tolerance, and Biologic Effects in Cancer Patients

8 July 2018

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Leukocyte Interferon-Induced Tumor Regression in Human Metastatic Breast Cancer, Multiple Myeloma, and Malignant Lymphoma

8 July 2018

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8 July 2018

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Molecular cloning of the cDNA for a growth factor-inducible gene with strong homology to S-100, a calcium-binding protein

8 July 2018

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8 July 2018

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8 July 2018

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Reactivity of neoplastic cells of hairy cell leukemia with antisera to S-100 protein

8 July 2018

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8 July 2018

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The molecular genetics of Philadelphia chromosome-positive leukemias

8 July 2018

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Conditioned tumorigenicity of activated oncogenes

8 July 2018

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The roles of stem cell self-renewal and autocrine growth factor production in the biology of myeloid leukemia.

8 July 2018

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Interferon beta increases expression of vimentin at the messenger RNA and protein levels in differentiated embryonal carcinoma (PSMB) cells

8 July 2018

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Tumor suppressor genes: the puzzle and the promise

8 July 2018

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Interferon-alpha but not AZT suppresses HIV expression in chronically infected cell lines

8 July 2018

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Roles of interferon produced in physiological conditions. A speculative review

8 July 2018

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Interferons and their actions

8 July 2018

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Interferon treatment of human neoplasia.

8 July 2018

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Clinical toxicity of interferons in cancer patients: a review

8 July 2018

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Inheritance of proliferative breast disease in breast cancer kindreds

8 July 2018

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The role of differentiation in the suppression of malignancy

8 July 2018

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Interferon selectively inhibits the expression of mitochondrial genes: a novel pathway for interferon-mediated responses

8 July 2018

1 reference

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Increased cell division as a cause of human cancer

8 July 2018

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TGF-beta: problems and prospects

8 July 2018

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Emerging viruses: defining the rules for viral traffic

8 July 2018

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8 July 2018

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Cellular adaptation in the origin and development of cancer

8 July 2018

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Fibrogenic cytokines: the role of immune mediators in the development of scar tissue

8 July 2018

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Molecular themes in oncogenesis

8 July 2018

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Interferon-alpha in patients with asymptomatic human immunodeficiency virus (HIV) infection. A randomized, placebo-controlled trial

8 July 2018

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T and B cell tolerance and responses to viral antigens in transgenic mice: implications for the pathogenesis of autoimmune versus immunopathological disease

8 July 2018

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Translocations, master genes, and differences between the origins of acute and chronic leukemias

8 July 2018

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Carcinogenesis and cancer: different perspectives on the same disease

8 July 2018

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Tumour progression and the nature of cancer

8 July 2018

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Interferon-alpha overrides the deficient adhesion of chronic myeloid leukemia primitive progenitor cells to bone marrow stromal cells.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Positive selection of candidate tumor-suppressor genes by subtractive hybridization

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Oncogenes and signal transduction

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Cell structure and DNA organization

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Mechanism of interferon action in hairy cell leukemia: a model of effective cancer biotherapy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

13-cis-Retinoic Acid Plus Interferon -2a: Highly Active Systemic Theraphy for Squamous Cell Carcinoma of the Cervix

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

13-cis-Retinoic Acid and Interferon -2a: Effective Combination. Therapy for Advanced Squamous Cell Carcinoma of the Skin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Many growth factors may not be growth factors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Interferon-alpha restores the deficient expression of the cytoadhesion molecule lymphocyte function antigen-3 by chronic myelogenous leukemia progenitor cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

The interferons. Mechanisms of action and clinical applications

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

What roles have anti-interferon antibodies in physiology and pathology?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Mechanism of Homeostatic Regulation of Tissue Growth and Reversion of Transformed Cells to Nonmalignancy: A Yin—Yang Problem

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Expression of Gene rrg Is Associated with Reversion of NIH 3Tt3 Transformed by LTR-c-H- ras

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Ubiquitin in health and disease.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Signal transduction in atherosclerosis: integration of cytokines and the eicosanoid network

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Basal cell and squamous cell carcinoma and Kaposi's sarcoma

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Potential role of the viral protease in human immunodeficiency virus type 1 associated pathogenesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Social controls on cell survival and cell death

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Altered cytokine production in black patients with keloids

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Stem cell regulation, tissue ontogeny, and oncogenic events

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

The growth arrest-specific gene, gas1, is involved in growth suppression

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Autocrine secretion--10 years later

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Differentiation requires continuous active control

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Interferon-alpha prevents endotoxin-induced mortality in mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Cytoskeleton--plasma membrane interactions

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Induction of TH1 and TH2 responses: a key role for the 'natural' immune response?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Interferon alfa combined with cytotoxic chemotherapy for patients with non-Hodgkin's lymphoma

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Virus proteins that counteract host immune defenses

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Interferon treatments: how to use an endogenous system as a therapeutic agent

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Inhibition of angiogenesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Extracellular matrix as a solid-state regulator in angiogenesis: identification of new targets for anti-cancer therapy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

The interferon system. A bird's eye view of its biochemistry

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Interferons in the persistence, pathogenesis, and treatment of HIV infection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Inhibitors of angiogenesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

The action of interferon alpha on human carcinoid tumours

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Human leukocyte interferon preparation blocks granulopoietic differentiation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Effects of genotypes of hepatitis C virus on interferon treatment for chronic type C hepatitis

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

The Gerhard Domagk Lecture. Transcription factors in lymphoid development

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Resistance of MHC class I-deficient mice to experimental systemic lupus erythematosus.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Investigation of bcr-abl transcription by Ph-positive chronic myeloid leukemia progenitors

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Tumor immunology: present perspectives.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Rous-Whipple Award Lecture. Viruses and diseases of the twenty-first century

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

N-acetyl cysteine enhances the response to interferon-alpha in chronic hepatitis C: a pilot study.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Neuroendocrine-immune interactions.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Nitric oxide and carbon monoxide produce activity-dependent long-term synaptic enhancement in hippocampus

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Interferon treatment of hepatitis C: Is it virological cure?

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Neuropsychiatric manifestations of human leukocyte interferon therapy in patients with cancer.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Linking cellular injury to gene expression and human proliferative disorders: examples with the PDGF genes

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43124

Adjuvant interferon treatment in human osteosarcoma

25 October 2018

1 reference

12 December 2020

Maintenance treatment with recombinant interferon alfa-2b in patients with multiple myeloma responding to conventional induction chemotherapy

1 reference

12 December 2020

Recombinant interferon alfa-2b combined with a regimen containing doxorubicin in patients with advanced follicular lymphoma. Groupe d'Etude des Lymphomes de l'Adulte

1 reference

12 December 2020

IL-4 and IFN (alpha and gamma) exert opposite regulatory effects on the development of cytolytic potential by Th1 or Th2 human T cell clones

1 reference

12 December 2020

Minimal residual disease in interferon-treated chronic myelogenous leukemia: results and pitfalls of analysis based on polymerase chain reaction

1 reference

12 December 2020

Suppression of chronic myelogenous leukemia colony growth by interleukin-1 (IL-1) receptor antagonist and soluble IL-1 receptors: a novel application for inhibitors of IL-1 activity

1 reference

12 December 2020

Favorable response of early stage B CLL patients to treatment with IFN-alpha 2

1 reference

12 December 2020

The Cytokine Network in Lesional and Lesion-Free Psoriatic Skin Is Characterized by a T-Helper Type 1 Cell-Mediated Response

1 reference

12 December 2020

Characterization of the alpha subunit of the IFN-alpha receptor. Evidence of N- and O-linked glycosylation and association with other surface proteins

1 reference

12 December 2020

Modulation of the invasive phenotype of human colon carcinoma cells by organ specific fibroblasts of nude mice

1 reference

12 December 2020

Interferon-alpha 2b inhibits proliferation of human Tenon's capsule fibroblasts

1 reference

12 December 2020

Hematologic remission and cytogenetic improvement induced by recombinant human interferon alpha A in chronic myelogenous leukemia

1 reference

12 December 2020

Interferon beta in multiple sclerosis

1 reference

12 December 2020

The environment strikes back

1 reference

12 December 2020

Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro

1 reference

12 December 2020

Elevated levels of the angiogenic peptide basic fibroblast growth factor in urine of bladder cancer patients

1 reference

12 December 2020

Human leukocyte interferon to control thrombocytosis in chronic myelogenous leukemia

1 reference

12 December 2020

A disturbance of interferon synthesis with the hyperproduction of unusual kinds of interferon can trigger autoimmune disease and play a pathogenetic role in AIDS: the removal of these interferons can be therapeutic

1 reference

12 December 2020

Treatment of hairy cell leukemia with recombinant alpha-interferon

1 reference

12 December 2020

Neutralizing antibodies to interferon-alpha: relative frequency in patients treated with different interferon preparations

1 reference

12 December 2020

Treatment of multiple myeloma with recombinant alpha-interferon

1 reference

12 December 2020

Induction of type I diabetes by interferon-alpha in transgenic mice

1 reference

12 December 2020

Interferon-alpha alters spectrin organization in normal and leukemic human B lymphocytes

1 reference

12 December 2020

Differential effects of recombinant interferon α on constitutive and inducible cytochrome P450 isozymes in mouse liver

1 reference

12 December 2020

Increased expression of the src proto-oncogene in hairy cell leukemia and a subgroup of B-cell lymphomas

1 reference

12 December 2020

Interferon-alpha produces sustained cytogenetic responses in chronic myelogenous leukemia. Philadelphia chromosome-positive patients

1 reference

12 December 2020

Psoriasis and alpha-interferon

1 reference

12 December 2020

1 reference

12 December 2020

A discriminant function analysis of various interferon parameters among alcoholics and heavy smokers

1 reference

12 December 2020

Prolonged subcutaneous administration of recombinant alpha 2b interferon in patients with previously untreated Philadelphia chromosome-positive chronic-phase chronic myelogenous leukemia: effect on remission duration and survival: Cancer and Leukemi

1 reference

12 December 2020

Induction of circulating IL-1 receptor antagonist by IFN treatment

1 reference

12 December 2020

Alpha interferon production in patients with hairy cell leukemia: correlations with disease activity and remission status

1 reference

12 December 2020

CHOP-Bleo plus interferon for stage IV low-grade lymphoma

1 reference

12 December 2020

Transforming growth factors beta 1 and alpha in chronic liver disease. Effects of interferon alfa therapy

1 reference

12 December 2020

Cytokine regulation of T-cell function: potential for therapeutic intervention

1 reference

12 December 2020

Tumor suppressor genes

1 reference

12 December 2020

Immune response in mice that lack the interferon-gamma receptor

1 reference

12 December 2020

Extracellular matrix and growth factors: an integrated interplay controlling tissue repair and progression to disease

1 reference

12 December 2020

VEGF/VPF: the angiogenesis factor found?

1 reference

12 December 2020

Introduction: new anticancer drug design and discovery based on advances in molecular oncology

1 reference

12 December 2020

Adhesion molecules on the plasma membrane of epidermal cells. III. Keratinocytes and Langerhans cells constitutively express the lymphocyte function-associated antigen 3

1 reference

12 December 2020

Treatment of chronic hepatitis D with interferon alfa-2a

1 reference

12 December 2020

Identification by differential display of alpha 6 integrin as a candidate tumor suppressor gene

1 reference

12 December 2020

Effects of interferon-beta on the translocation rate and stationary time in human fibroblasts in culture

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.91.4.1198

1 reference

5 August 2017

0 references

1 reference

5 August 2017

1 reference