Novel chemical genetic approaches to the discovery of signal transduction inhibitors (Q35053197)

6 August 2017

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title

Novel chemical genetic approaches to the discovery of signal transduction inhibitors (English)

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6 August 2017

Kevan Shokat

1

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6 August 2017

Mark Velleca

series ordinal

2

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6 August 2017

publication date

1 August 2002

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6 August 2017

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6 August 2017

volume

7

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6 August 2017

issue

16

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6 August 2017

page(s)

872-879

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Chemogenomic approaches to drug discovery

6 August 2017

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Controlling Signal Transduction with Synthetic Ligands

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TGF-beta-signaling with small molecule FKBP12 antagonists that bind myristoylated FKBP12-TGF-beta type I receptor fusion proteins

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Rapid targeting of nuclear proteins to the cytoplasm

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Magic bullets for protein kinases

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A chemical switch for inhibitor-sensitive alleles of any protein kinase

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Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme

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Engineering Src family protein kinases with unnatural nucleotide specificity

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Identification of new JNK substrate using ATP pocket mutant JNK and a corresponding ATP analogue.

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A chemical genetic screen for direct v-Src substrates reveals ordered assembly of a retrograde signaling pathway

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Engineering of the myosin-ibeta nucleotide-binding pocket to create selective sensitivity to N(6)-modified ADP analogs

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A chemical-genetic strategy implicates myosin-1c in adaptation by hair cells.

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Allele-specific activators and inhibitors for kinesin

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Identifiers

DOI

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6 August 2017

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