Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions (Q35076939)

6 August 2017

title

Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions (English)

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6 August 2017

6

J W Shay

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6 August 2017

R D Ramirez

1

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6 August 2017

C P Morales

2

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6 August 2017

B S Herbert

3

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6 August 2017

J M Rohde

4

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6 August 2017

C Passons

5

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6 August 2017

W E Wright

7

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6 August 2017

publication date

1 February 2001

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6 August 2017

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6 August 2017

volume

15

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6 August 2017

issue

4

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6 August 2017

page(s)

398-403

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The serial cultivation of human diploid cell strains

6 August 2017

cites work

1 reference

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Cellular senescence: mitotic clock or culture shock?

8 July 2018

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Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology

8 July 2018

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Evidence for a telomere-independent "clock" limiting RAS oncogene-driven proliferation of human thyroid epithelial cells

8 July 2018

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Genetic and epigenetic changes in human epithelial cells immortalized by telomerase

8 July 2018

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Telomere shortening is proportional to the size of the G-rich telomeric 3'-overhang

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=312628

Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion

8 July 2018

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The p53 tumor suppressor protein does not regulate expression of its own inhibitor, MDM2, except under conditions of stress

8 July 2018

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The establishment of telomerase-immortalized cell lines representing human chromosome instability syndromes

8 July 2018

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Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=312628

Human endothelial cell life extension by telomerase expression

8 July 2018

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Absence of cancer-associated changes in human fibroblasts immortalized with telomerase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=312628

Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=312628

Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts

8 July 2018

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Inactivation of p16 in human mammary epithelial cells by CpG island methylation

8 July 2018

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TRF2 Protects Human Telomeres from End-to-End Fusions

8 July 2018

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Extension of life-span by introduction of telomerase into normal human cells

8 July 2018

1 reference

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Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

8 July 2018

1 reference

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Cell aging in vivo and in vitro

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=312628

Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=312628

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=312628

Telomerase activity in human germline and embryonic tissues and cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=312628

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

8 July 2018

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Identification of a specific telomere terminal transferase activity in Tetrahymena extracts

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=312628

Extended culture of mouse embryo cells without senescence: inhibition by serum.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=312628

Serum amine oxidase activity contributes to crisis in mouse embryo cell lines

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=312628

Telomeres shorten during ageing of human fibroblasts

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=312628

Telomere loss: mitotic clock or genetic time bomb?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=312628

The two-stage mechanism controlling cellular senescence and immortalization

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=312628

Microarray analysis of replicative senescence

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=312628

Positive correlation between mammalian life span and cellular resistance to stress.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=312628

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=312628

Telomerase and cellular lifespan: ending the debate?

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=312628

Evidence for a new step in telomere maintenance

27 September 2018

1 reference

12 December 2020

Properties of an epithelial cell type in culture: the epidermal keratinocyte and its dependence on products of the fibroblast

1 reference

12 December 2020

Growth of normal human mammary cells in culture

1 reference

12 December 2020

Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span

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12 December 2020

p16/pRb pathway alterations are required for bypassing senescence in human prostate epithelial cells

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12 December 2020

Identifiers

DOI

10.1101/GAD.859201

1 reference

6 August 2017

1 reference

6 August 2017

1 reference