Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers (Q35092542)

24520176

6 August 2017

title

Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers (English)

1 reference

6 August 2017

1 reference

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520176%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Rodrigo Romero

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520176%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Charles W Roberts

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520176%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

author name string

Gregory R Hoffman

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520176%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Rami Rahal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520176%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Frank Buxton

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520176%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Kay Xiang

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520176%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Gregory McAllister

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520176%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Elizabeth Frias

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520176%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Linda Bagdasarian

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520176%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Janina Huber

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520176%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Alicia Lindeman

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520176%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Dongshu Chen

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520176%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Nadire Ramadan

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520176%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Tanushree Phadke

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520176%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Kristy Haas

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520176%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Mariela Jaskelioff

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520176%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Boris G Wilson

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520176%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Matthew J Meyer

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520176%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Veronica Saenz-Vash

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520176%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Huili Zhai

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520176%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Vic E Myer

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520176%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Jeffery A Porter

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520176%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Nicholas Keen

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520176%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Margaret E McLaughlin

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520176%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Craig Mickanin

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520176%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Frank Stegmeier

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520176%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Zainab Jagani

28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520176%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

language of work or name

English

0 references

publication date

11 February 2014

1 reference

24520176

6 August 2017

number of pages

6

1 reference

Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520176%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

volume

111

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520176%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520176%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

page(s)

3128-3133

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520176%20AND%20SRC:MED&resulttype=core&format=json

A synthetic lethality-based strategy to treat cancers harboring a genetic deficiency in the chromatin remodeling factor BRG1.

5 June 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3939885

BAF complexes facilitate decatenation of DNA by topoisomerase IIα

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3939885

Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3939885

A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3939885

The spectrum of SWI/SNF mutations, ubiquitous in human cancers

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3939885

ATARiS: computational quantification of gene suppression phenotypes from multisample RNAi screens

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3939885

Lung cancer with loss of BRG1/BRM, shows epithelial mesenchymal transition phenotype and distinct histologic and genetic features

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3939885

Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3939885

Cancer genetics and epigenetics: two sides of the same coin?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3939885

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3939885

A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3939885

SWI/SNF nucleosome remodellers and cancer.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3939885

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3939885

The genetic landscape of the childhood cancer medulloblastoma

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3939885

Vigilance and validation: Keys to success in RNAi screening

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3939885

ARID1A mutations in endometriosis-associated ovarian carcinomas

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3939885

Oncogenesis caused by loss of the SNF5 tumor suppressor is dependent on activity of BRG1, the ATPase of the SWI/SNF chromatin remodeling complex.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3939885

The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16INK4a

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3939885

Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3939885

Utilizing RNA interference to enhance cancer drug discovery

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3939885

Role for BRG1 in cell cycle control and tumor suppression

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3939885

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3939885

Transcriptional specificity of human SWI/SNF BRG1 and BRM chromatin remodeling complexes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3939885

A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3939885

Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3939885

BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3939885

Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3939885

Altered control of cellular proliferation in the absence of mammalian brahma (SNF2alpha).

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3939885

Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3939885

Purification and biochemical heterogeneity of the mammalian SWI-SNF complex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3939885

A probability-based approach for the analysis of large-scale RNAi screens.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3939885

Characterization of mammary tumors from Brg1 heterozygous mice.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3939885

Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24520176

12 December 2020

inferred from PubMed ID database lookup

Loss of BRG1/BRM in human lung cancer cell lines and primary lung cancers: correlation with poor prognosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24520176

12 December 2020

inferred from PubMed ID database lookup

Loss of BAF250a (ARID1A) is frequent in high-grade endometrial carcinomas

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24520176

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1073/PNAS.1316793111

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520176%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24520176%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

24520176

1 reference