Tumor promoter-induced cellular senescence: cell cycle arrest followed by geroconversion (Q35149607)

6 August 2017

title

Tumor promoter-induced cellular senescence: cell cycle arrest followed by geroconversion (English)

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6 August 2017

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2

Mikhail V Blagosklonny

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6 August 2017

Olga V Leontieva

1

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6 August 2017

language of work or name

English

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publication date

1 December 2014

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6 August 2017

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6 August 2017

volume

5

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6 August 2017

issue

24

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6 August 2017

page(s)

12715-12727

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Geroconversion of aged muscle stem cells under regenerative pressure

6 August 2017

cites work

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Geroconversion: irreversible step to cellular senescence

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Rapamycin treatment of Mandibuloacral dysplasia cells rescues localization of chromatin-associated proteins and cell cycle dynamics

13 July 2018

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Contact inhibition against senescence

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Contact inhibition and high cell density deactivate the mammalian target of rapamycin pathway, thus suppressing the senescence program

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Geriatric muscle stem cells switch reversible quiescence into senescence.

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13 July 2018

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13 July 2018

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mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome

13 July 2018

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Metformin inhibits skin tumor promotion in overweight and obese mice

13 July 2018

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13 July 2018

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Rapamycin enhances long-term hematopoietic reconstitution of ex vivo expanded mouse hematopoietic stem cells by inhibiting senescence

13 July 2018

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S6K in geroconversion

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Berberine suppresses gero-conversion from cell cycle arrest to senescence

13 July 2018

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CDK4/6-inhibiting drug substitutes for p21 and p16 in senescence: duration of cell cycle arrest and MTOR activity determine geroconversion

13 July 2018

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Rapamycin extends life- and health span because it slows aging

13 July 2018

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Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance

13 July 2018

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M(o)TOR of aging: MTOR as a universal molecular hypothalamus

13 July 2018

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MEK drives cyclin D1 hyperelevation during geroconversion

13 July 2018

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Rapamycin suppresses brain aging in senescence-accelerated OXYS rats

13 July 2018

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13 July 2018

The hallmarks of aging

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mTOR pathway and Ca²⁺ stores mobilization in aged smooth muscle cells

13 July 2018

1 reference

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Big mice die young but large animals live longer

13 July 2018

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Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy.

13 July 2018

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Temporal mTOR inhibition protects Fbxw7-deficient mice from radiation-induced tumor development.

13 July 2018

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Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumors

13 July 2018

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Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

13 July 2018

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Recent discoveries in the cycling, growing and aging of the p53 field

13 July 2018

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Answering the ultimate question "what is the proximal cause of aging?"

13 July 2018

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Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling

13 July 2018

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Senescence regulation by mTOR.

13 July 2018

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Hyper-mitogenic drive coexists with mitotic incompetence in senescent cells

13 July 2018

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Rapalogs in cancer prevention: anti-aging or anticancer?

13 July 2018

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Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/- mice

13 July 2018

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New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53-/- mice by delaying carcinogenesis

13 July 2018

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Glutaminolysis feeds mTORC1.

13 July 2018

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Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence

13 July 2018

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Matters of life and breath: A role for hypoxia in determining cell state.

13 July 2018

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How to save Medicare: the anti-aging remedy

13 July 2018

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Alternative Perspectives on Aging in Caenorhabditis elegans: Reactive Oxygen Species or Hyperfunction?

13 July 2018

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Tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression?

13 July 2018

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Hypoxia suppresses conversion from proliferative arrest to cellular senescence

13 July 2018

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Prospective treatment of age-related diseases by slowing down aging

13 July 2018

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Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival.

13 July 2018

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Chemoprevention of age-related macular regeneration (AMD) with rapamycin

13 July 2018

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Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice

13 July 2018

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Replicatively senescent cells are arrested in G1 and G2 phases

13 July 2018

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Once again on rapamycin-induced insulin resistance and longevity: despite of or owing to.

13 July 2018

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Suppression of replicative senescence by rapamycin in rodent embryonic cells

13 July 2018

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Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence.

13 July 2018

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Status of mTOR activity may phenotypically differentiate senescence and quiescence

13 July 2018

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Rapamycin increases oxidative stress response gene expression in adult stem cells

13 July 2018

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13 July 2018

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13 July 2018

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Molecular damage in cancer: an argument for mTOR-driven aging

13 July 2018

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mTOR signaling in disease

13 July 2018

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Rapamycin is a potent inhibitor of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate

13 July 2018

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Rapamycin and mTORC1 inhibition in the mouse: skin cancer prevention

13 July 2018

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DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence

13 July 2018

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mTOR: from growth signal integration to cancer, diabetes and ageing

13 July 2018

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The p53 inducing drug dosage may determine quiescence or senescence

13 July 2018

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Weak p53 permits senescence during cell cycle arrest

13 July 2018

1 reference

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Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

13 July 2018

1 reference

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Xenohormetic, hormetic and cytostatic selective forces driving longevity at the ecosystemic level

13 July 2018

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Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes

13 July 2018

1 reference

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The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway

13 July 2018

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Paradoxical suppression of cellular senescence by p53

13 July 2018

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Growth and aging: a common molecular mechanism

13 July 2018

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Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice.

13 July 2018

1 reference

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An emerging role of mTOR in lipid biosynthesis.

13 July 2018

1 reference

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Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles

13 July 2018

1 reference

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Rapamycin decelerates cellular senescence

13 July 2018

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mTORC1 signaling governs hematopoietic stem cell quiescence

13 July 2018

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mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization

13 July 2018

1 reference

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Growth stimulation leads to cellular senescence when the cell cycle is blocked

13 July 2018

1 reference

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The binding of PRAS40 to 14-3-3 proteins is not required for activation of mTORC1 signalling by phorbol esters/ERK.

13 July 2018

1 reference

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RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation

13 July 2018

1 reference

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Phorbol 12-myristate 13-acetate and serum synergize to promote rapamycin-insensitive cell proliferation via protein kinase C-eta

13 July 2018

1 reference

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mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

13 July 2018

1 reference

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Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase

13 July 2018

1 reference

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The expanding TOR signaling network

13 July 2018

1 reference

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Regulation of adipocyte differentiation and insulin action with rapamycin.

13 July 2018

1 reference

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Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350340

The multifaceted role of mTOR in cellular stress responses

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350340

Inhibition of phosphatidylinostol 3-kinase uncouples H2O2-induced senescent phenotype and cell cycle arrest in normal human diploid fibroblasts

13 July 2018

1 reference

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The normal response to RAS: senescence or transformation?

13 July 2018

1 reference

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Cell senescence and hypermitogenic arrest

13 July 2018

1 reference

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Phosphatidylinositol 3-kinase regulates PMA-induced differentiation and superoxide production in HL-60 cells

13 July 2018

1 reference

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Oncogenic resistance to growth-limiting conditions

13 July 2018

1 reference

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c-Raf/MEK/ERK pathway controls protein kinase C-mediated p70S6K activation in adult cardiac muscle cells.

13 July 2018

1 reference

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Cell senescence and cancer

13 July 2018

1 reference

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The extracellular signal-regulated kinase pathway regulates the phosphorylation of 4E-BP1 at multiple sites

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350340

Uncoupling between phenotypic senescence and cell cycle arrest in aging p21-deficient fibroblasts

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350340

Cellular response to oncogenic ras involves induction of the Cdk4 and Cdk6 inhibitor p15(INK4b)

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350340

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350340

Senescence of human fibroblasts induced by oncogenic Raf.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350340

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350340

Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350340

p53 suppresses stress-induced cellular senescence via regulation of autophagy under the deprivation of serum.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350340

Inhibition of Akt/mTOR attenuates age-related changes in mesenchymal stem cells.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350340

Metformin and rapamycin are master-keys for understanding the relationship between cell senescent, aging and cancer

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350340

Inhibition of TORC1 signaling and increased lifespan: gained in translation?

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350340

Signalling pathways regulating muscle mass in ageing skeletal muscle: the role of the IGF1-Akt-mTOR-FoxO pathway.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350340

Rapamycin as longevity enhancer and cancer preventative agent in the context of p53 deficiency

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350340

Dissecting the role of mTOR complexes in cellular senescence

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350340

Sensing senescence in preterm birth.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350340

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350340

Disruption of Tsc2 in oocytes leads to overactivation of the entire pool of primordial follicles.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350340

p21(Waf1/Cip1/Sdi1) mediates retinoblastoma protein degradation.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350340

Mammalian target of rapamycin (mTOR) regulates both proliferation of megakaryocyte progenitors and late stages of megakaryocyte differentiation.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350340

Suppressing cancer: the importance of being senescent.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350340

Akt1/Akt2 and mammalian target of rapamycin/Bim play critical roles in osteoclast differentiation and survival, respectively, whereas Akt is dispensable for cell survival in isolated osteoclast precursors

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350340

Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25587030

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The mitogen-activated protein kinase pathway mediates growth arrest or E1A-dependent apoptosis in SKBR3 human breast cancer cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25587030

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated kinase (ERK), and p90(RSK) in the control of mTORC1 protein signaling by

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25587030

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.18632/ONCOTARGET.3011

0 references

PMC publication ID

4350340

1 reference

6 August 2017

1 reference