Specific targeting of the GABA-A receptor α5 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice (Q35177041)

6 August 2017

title

Specific targeting of the GABA-A receptor α5 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice (English)

1 reference

6 August 2017

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J Braudeau

1

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ORCID Public Data File 2021

Benoît Delatour

object named as

B Delatour

2

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ORCID Public Data File 2021

author name string

A Duchon

3

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6 August 2017

P Lopes Pereira

4

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6 August 2017

L Dauphinot

5

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6 August 2017

F de Chaumont

6

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6 August 2017

J-C Olivo-Marin

7

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6 August 2017

R H Dodd

8

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6 August 2017

Y Hérault

9

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6 August 2017

M-C Potier

10

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6 August 2017

language of work or name

English

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publication date

21 June 2011

1 reference

Journal of Psychopharmacology

6 August 2017

published in

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6 August 2017

volume

25

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6 August 2017

issue

8

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6 August 2017

page(s)

1030-1042

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Preclinical and clinical pharmacology of the GABAA receptor alpha5 subtype-selective inverse agonist alpha5IA.

6 August 2017

cites work

1 reference

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GABA(A) receptor subtype-selective efficacy: TPA023, an alpha2/alpha3 selective non-sedating anxiolytic and alpha5IA, an alpha5 selective cognition enhancer

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A year of unprecedented progress in Down syndrome basic research

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L-655,708 enhances cognition in rats but is not proconvulsant at a dose selective for alpha5-containing GABAA receptors.

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An inverse agonist selective for alpha5 subunit-containing GABAA receptors improves encoding and recall but not consolidation in the Morris water maze.

13 July 2018

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An inverse agonist selective for alpha5 subunit-containing GABAA receptors enhances cognition.

13 July 2018

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Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome.

13 July 2018

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Selective, orally active gamma-aminobutyric acidA alpha5 receptor inverse agonists as cognition enhancers.

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Autoradiographic localization of alpha5 subunit-containing GABAA receptors in rat brain

13 July 2018

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Altered long-term potentiation in the young and old Ts65Dn mouse, a model for Down Syndrome.

13 July 2018

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A mouse model for Down syndrome exhibits learning and behaviour deficits.

13 July 2018

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Chronic pentylenetetrazole but not donepezil treatment rescues spatial cognition in Ts65Dn mice, a model for Down syndrome

13 July 2018

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Blockade of alcohol's amnestic activity in humans by an alpha5 subtype benzodiazepine receptor inverse agonist

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27 September 2018

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27 September 2018

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Ts65Dn, a mouse model of Down syndrome, exhibits increased GABAB-induced potassium current

27 September 2018

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27 September 2018

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27 September 2018

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27 September 2018

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27 September 2018

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A behavioral assessment of Ts65Dn mice: a putative Down syndrome model.

27 September 2018

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27 September 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/21693554

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Characterization of the solubility of a poorly soluble hydroxylated metabolite in human urine and its implications for potential renal toxicity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21693554

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1177/0269881111405366

1 reference

6 August 2017

1 reference

6 August 2017

1 reference