Specific roles of each TCR hemichain in generating functional chain-centric TCR. (Q35205495)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25710913%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

title

Specific roles of each TCR hemichain in generating functional chain-centric TCR (English)

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1 March 2020

7

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1 March 2020

author name string

Munehide Nakatsugawa

1

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1 March 2020

Yuki Yamashita

2

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1 March 2020

Toshiki Ochi

3

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1 March 2020

Shinya Tanaka

4

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1 March 2020

Kenji Chamoto

5

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1 March 2020

Tingxi Guo

6

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1 March 2020

Naoto Hirano

8

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1 March 2020

language of work or name

English

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publication date

20 February 2015

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1 March 2020

published in

Journal of Immunology

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1 March 2020

volume

194

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1 March 2020

issue

7

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1 March 2020

page(s)

3487-3500

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Computational Design of the Affinity and Specificity of a Therapeutic T Cell Receptor

1 March 2020

cites work

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Identification of a Titin-derived HLA-A1-presented peptide as a cross-reactive target for engineered MAGE A3-directed T cells

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T-cell Receptor Specificity Maintained by Altered Thermodynamics

28 July 2018

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Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy

28 July 2018

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Interplay between T cell receptor binding kinetics and the level of cognate peptide presented by major histocompatibility complexes governs CD8+ T cell responsiveness

28 July 2018

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Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer

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IL-21 can supplement suboptimal Lck-independent MAPK activation in a STAT-3-dependent manner in human CD8(+) T cells

28 July 2018

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T Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility Complex

28 July 2018

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Single-chain VαVβ T-cell receptors function without mispairing with endogenous TCR chains.

28 July 2018

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Induction of HLA-DP4-restricted anti-survivin Th1 and Th2 responses using an artificial antigen-presenting cell

28 July 2018

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Establishment of antitumor memory in humans using in vitro-educated CD8+ T cells

28 July 2018

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Bias in the αβ T-cell repertoire: implications for disease pathogenesis and vaccination

28 July 2018

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Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1

28 July 2018

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A panel of human cell-based artificial APC enables the expansion of long-lived antigen-specific CD4+ T cells restricted by prevalent HLA-DR alleles

28 July 2018

1 reference

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Overlap and Effective Size of the Human CD8 + T Cell Receptor Repertoire

28 July 2018

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Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition

28 July 2018

1 reference

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Molecular immunology lessons from therapeutic T-cell receptor gene transfer

28 July 2018

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Evidence for a TCR affinity threshold delimiting maximal CD8 T cell function.

28 July 2018

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MM-GBSA binding free energy decomposition and T cell receptor engineering

28 July 2018

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Public TCR use by herpes simplex virus-2-specific human CD8 CTLs.

28 July 2018

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T cell receptor gene therapy: strategies for optimizing transgenic TCR pairing

28 July 2018

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Germ Line-governed Recognition of a Cancer Epitope by an Immunodominant Human T-cell Receptor

28 July 2018

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Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

28 July 2018

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Engineering higher affinity T cell receptors using a T cell display system

28 July 2018

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Dissociation of its opposing immunologic effects is critical for the optimization of antitumor CD8+ T-cell responses induced by interleukin 21

28 July 2018

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Structure-based design of a T-cell receptor leads to nearly 100-fold improvement in binding affinity for pepMHC.

28 July 2018

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Development of optimal bicistronic lentiviral vectors facilitates high-level TCR gene expression and robust tumor cell recognition

28 July 2018

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Phase 1 trial of intranodal injection of a Melan-A/MART-1 DNA plasmid vaccine in patients with stage IV melanoma

28 July 2018

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Single and dual amino acid substitutions in TCR CDRs can enhance antigen-specific T cell functions

28 July 2018

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The fidelity, occasional promiscuity, and versatility of T cell receptor recognition

28 July 2018

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The molecular basis for public T-cell responses?

28 July 2018

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High-affinity TCRs generated by phage display provide CD4+ T cells with the ability to recognize and kill tumor cell lines.

28 July 2018

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Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'

28 July 2018

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Structural determinants of T-cell receptor bias in immunity

28 July 2018

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Facilitating matched pairing and expression of TCR chains introduced into human T cells

28 July 2018

1 reference

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Phase I study of adoptive T-cell therapy using antigen-specific CD8+ T cells for the treatment of patients with metastatic melanoma.

28 July 2018

1 reference

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Gene transfer of tumor-reactive TCR confers both high avidity and tumor reactivity to nonreactive peripheral blood mononuclear cells and tumor-infiltrating lymphocytes

28 July 2018

1 reference

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Enhanced antitumor activity of murine-human hybrid T-cell receptor (TCR) in human lymphocytes is associated with improved pairing and TCR/CD3 stability

28 July 2018

1 reference

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Cancer regression in patients after transfer of genetically engineered lymphocytes

28 July 2018

1 reference

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Identification of an immunogenic CD8+ T-cell epitope derived from gamma-globin, a putative tumor-associated antigen for juvenile myelomonocytic leukemia

28 July 2018

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Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity

28 July 2018

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Engagement of CD83 ligand induces prolonged expansion of CD8+ T cells and preferential enrichment for antigen specificity

28 July 2018

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Antigenicity and immunogenicity of Melan-A/MART-1 derived peptides as targets for tumor reactive CTL in human melanoma.

28 July 2018

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Adoptive T cell therapy using antigen-specific CD8+ T cell clones for the treatment of patients with metastatic melanoma: in vivo persistence, migration, and antitumor effect of transferred T cells

28 July 2018

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Degeneracy of antigen recognition as the molecular basis for the high frequency of naive A2/Melan-a peptide multimer(+) CD8(+) T cells in humans

28 July 2018

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Thymic selection generates a large T cell pool recognizing a self-peptide in humans

28 July 2018

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An endoplasmic reticulum retention function for the cytoplasmic tail of the human pre-T cell receptor (TCR) alpha chain: potential role in the regulation of cell surface pre-TCR expression levels

28 July 2018

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Changing T cell specificity by retroviral T cell receptor display

28 July 2018

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Efficient simultaneous presentation of NY-ESO-1/LAGE-1 primary and nonprimary open reading frame-derived CTL epitopes in melanoma

28 July 2018

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Identification of NY-ESO-1 peptide analogues capable of improved stimulation of tumor-reactive CTL.

28 July 2018

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In vitro evolution of a T cell receptor with high affinity for peptide/MHC.

28 July 2018

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New experimental approaches in retrovirus-mediated expression screening

28 July 2018

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Enhancement of cellular immunity in melanoma patients immunized with a peptide from MART-1/Melan A

28 July 2018

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Structure of the complex between human T-cell receptor, viral peptide and HLA-A2

28 July 2018

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Serological analysis of Melan-A(MART-1), a melanocyte-specific protein homogeneously expressed in human melanomas

28 July 2018

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A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas

28 July 2018

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Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma.

28 July 2018

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The impact of a large and frequent deletion in the human TCR β locus on antiviral immunity

26 September 2018

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A single autoimmune T cell receptor recognizes more than a million different peptides

26 September 2018

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Transgenic mice with a diverse human T cell antigen receptor repertoire.

26 September 2018

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Mixed T cell receptor dimers harbor potentially harmful neoreactivity

26 September 2018

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Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy

26 September 2018

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Improved expression and reactivity of transduced tumor-specific TCRs in human lymphocytes by specific silencing of endogenous TCR.

26 September 2018

1 reference

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Fine structural variations of alphabetaTCRs selected by vaccination with natural versus altered self-antigen in melanoma patients

26 September 2018

1 reference

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Treatment of metastatic melanoma with autologous Melan-A/MART-1-specific cytotoxic T lymphocyte clones.

26 September 2018

1 reference

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Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition

26 September 2018

1 reference

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Enhanced antitumor activity of T cells engineered to express T-cell receptors with a second disulfide bond.

26 September 2018

1 reference

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Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function

26 September 2018

1 reference

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Directed evolution of human T-cell receptors with picomolar affinities by phage display.

26 September 2018

1 reference

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Stable, soluble T-cell receptor molecules for crystallization and therapeutics

26 September 2018

1 reference

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Prevalent role of TCR alpha-chain in the selection of the preimmune repertoire specific for a human tumor-associated self-antigen.

26 September 2018

1 reference

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Dominant TCR V alpha usage by virus and tumor-reactive T cells with wide affinity ranges for their specific antigens.

26 September 2018

1 reference

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Predominant role of T cell receptor (TCR)-alpha chain in forming preimmune TCR repertoire revealed by clonal TCR reconstitution system

26 September 2018

1 reference

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Peptide-specific CD8+ T-cell evolution in vivo: response to peptide vaccination with Melan-A/MART-1.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4369446

The human CD8 coreceptor effects cytotoxic T cell activation and antigen sensitivity primarily by mediating complete phosphorylation of the T cell receptor zeta chain.

26 September 2018

1 reference

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Expansion and functional maturation of human tumor antigen-specific CD8+ T cells after vaccination with antigenic peptide.

26 September 2018

1 reference

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Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor

26 September 2018

1 reference

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Cytotoxic T-lymphocyte clones from different patients display limited T-cell-receptor variable-region gene usage in HLA-A2-restricted recognition of the melanoma antigen Melan-A/MART-1.

26 September 2018

1 reference

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Long-lived antitumor CD8+ lymphocytes for adoptive therapy generated using an artificial antigen-presenting cell

26 September 2018

1 reference

12 December 2020

Tetramer-guided analysis of TCR beta-chain usage reveals a large repertoire of melan-A-specific CD8+ T cells in melanoma patients

1 reference

12 December 2020

Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion

1 reference

12 December 2020

Efficient presentation of naturally processed HLA class I peptides by artificial antigen-presenting cells for the generation of effective antitumor responses

1 reference

12 December 2020

Redirection of antileukemic reactivity of peripheral T lymphocytes using gene transfer of minor histocompatibility antigen HA-2-specific T-cell receptor complexes expressing a conserved alpha joining region

1 reference

12 December 2020

Identifiers

DOI

10.4049/JIMMUNOL.1401717

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25710913%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25710913%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

PubMed publication ID

25710913

1 reference