Engineering proteins that bind, move, make and break DNA. (Q35207823)

7 August 2017

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title

Engineering proteins that bind, move, make and break DNA. (English)

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7 August 2017

4

Frances H Arnold

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7 August 2017

Cynthia H Collins

1

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author name string

Yohei Yokobayashi

series ordinal

2

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7 August 2017

Daisuke Umeno

series ordinal

3

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7 August 2017

publication date

1 August 2003

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Current Opinion in Biotechnology

7 August 2017

published in

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7 August 2017

volume

14

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7 August 2017

issue

4

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7 August 2017

page(s)

371-378

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Changing the binding specificity of a repressor by redesigning an alpha-helix

7 August 2017

cites work

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7 January 2021

A repressor heterodimer binds to a chimeric operator

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7 January 2021

Single-chain lambda Cro repressors confirm high intrinsic dimer-DNA affinity

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7 January 2021

Single chain dimers of MASH-1 bind DNA with enhanced affinity

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7 January 2021

Dimerizing the estrogen receptor DNA binding domain enhances binding to estrogen response elements

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7 January 2021

Single-chain repressors containing engineered DNA-binding domains of the phage 434 repressor recognize symmetric or asymmetric DNA operators

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7 January 2021

Affinity selective isolation of ligands from peptide libraries through display on a lac repressor "headpiece dimer".

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7 January 2021

Covalent attachment of Arc repressor subunits by a peptide linker enhances affinity for operator DNA.

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7 January 2021

Rationally designed helix-turn-helix proteins and their conformational changes upon DNA binding.

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7 January 2021

Modular construction of extended DNA recognition surfaces: mutant DNA-binding domains of the 434 repressor as building blocks

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7 January 2021

Design and selection of novel Cys2His2 zinc finger proteins

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7 January 2021

Engineering polydactyl zinc-finger transcription factors

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7 January 2021

Toward controlling gene expression at will: selection and design of zinc finger domains recognizing each of the 5'-GNN-3' DNA target sequences

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7 January 2021

Development of zinc finger domains for recognition of the 5'-ANN-3' family of DNA sequences and their use in the construction of artificial transcription factors

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7 January 2021

Evaluation of a modular strategy for the construction of novel polydactyl zinc finger DNA-binding proteins

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7 January 2021

Validated zinc finger protein designs for all 16 GNN DNA triplet targets

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7 January 2021

A rapid, generally applicable method to engineer zinc fingers illustrated by targeting the HIV-1 promoter

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7 January 2021

Rational design of artificial zinc-finger proteins using a nondegenerate recognition code table.

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7 January 2021

Regulation of gene expression in Arabidopsis thaliana by artificial zinc finger chimeras

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7 January 2021

Controlling gene expression in plants using synthetic zinc finger transcription factors

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7 January 2021

Heritable endogenous gene regulation in plants with designed polydactyl zinc finger transcription factors

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7 January 2021

Regulation of transgene expression in plants with polydactyl zinc finger transcription factors

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7 January 2021

Repression of the HIV-1 5' LTR promoter and inhibition of HIV-1 replication by using engineered zinc-finger transcription factors

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7 January 2021

Inhibition of herpes simplex virus 1 gene expression by designer zinc-finger transcription factors

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7 January 2021

Induction of angiogenesis in a mouse model using engineered transcription factors

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7 January 2021

Scanning the human genome with combinatorial transcription factor libraries.

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7 January 2021

Regulation of an endogenous locus using a panel of designed zinc finger proteins targeted to accessible chromatin regions. Activation of vascular endothelial growth factor A.

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7 January 2021

On the possibilities and limitations of rational protein design to expand the specificity of restriction enzymes: a case study employing EcoRV as the target

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7 January 2021

Towards the design of rare cutting restriction endonucleases: using directed evolution to generate variants of EcoRV differing in their substrate specificity by two orders of magnitude

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7 January 2021

Directed evolution of novel polymerase activities: mutation of a DNA polymerase into an efficient RNA polymerase

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7 January 2021

Directed evolution of restriction endonuclease BstYI to achieve increased substrate specificity

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7 January 2021

Mutations altering the cleavage specificity of a homing endonuclease

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7 January 2021

Homing endonucleases: structural and functional insight into the catalysts of intron/intein mobility

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7 January 2021

Design, activity, and structure of a highly specific artificial endonuclease

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7 January 2021

From mouse to man: generating megabase chromosome rearrangements

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7 January 2021

High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP

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7 January 2021

Site-specific recombinases: tools for genome engineering.

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7 January 2021

Stepwise manipulation of DNA specificity in Flp recombinase: progressively adapting Flp to individual and combinatorial mutations in its target site

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7 January 2021

A dual reporter screening system identifies the amino acid at position 82 in Flp site-specific recombinase as a determinant for target specificity

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7 January 2021

Directed evolution of the site specificity of Cre recombinase

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7 January 2021

Non-contact positions impose site selectivity on Cre recombinase

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7 January 2021

Alteration of Cre recombinase site specificity by substrate-linked protein evolution.

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7 January 2021

Prokaryotic DNA polymerase I: evolution, structure, and "base flipping" mechanism for nucleotide selection

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7 January 2021

Mutations in human DNA polymerase eta motif II alter bypass of DNA lesions

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7 January 2021

In vivo mutagenesis by Escherichia coli DNA polymerase I. Ile(709) in motif A functions in base selection.

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7 January 2021

Multiple amino acid substitutions allow DNA polymerases to synthesize RNA.

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7 January 2021

Enzymatic properties of rat DNA polymerase beta mutants obtained by randomized mutagenesis

1 reference

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7 January 2021

In vitro production and screening of DNA polymerase eta mutants for catalytic diversity

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https://api.crossref.org/works/10.1016%2FS0958-1669%2803%2900091-0

7 January 2021

Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta.

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https://api.crossref.org/works/10.1016%2FS0958-1669%2803%2900091-0

7 January 2021

Efforts toward expansion of the genetic alphabet: replication of DNA with three base pairs

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2803%2900091-0

7 January 2021

Directed evolution of polymerase function by compartmentalized self-replication

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2803%2900091-0

7 January 2021

10.1016/S0958-1669(03)00091-0

Identifiers

DOI

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7 August 2017

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