Regulatory T cells require TCR signaling for their suppressive function (Q35472407)

25821220

8 August 2017

title

Regulatory T cells require TCR signaling for their suppressive function (English)

1 reference

8 August 2017

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25821220%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

author name string

Amanda M Schmidt

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25821220%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Wen Lu

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25821220%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Vishal J Sindhava

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25821220%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Yanping Huang

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25821220%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Enjun Yang

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25821220%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Matthew J Riese

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25821220%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Jonathan S Maltzman

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25821220%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Martha S Jordan

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25821220%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Taku Kambayashi

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25821220%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

language of work or name

English

0 references

publication date

27 March 2015

1 reference

25821220

8 August 2017

published in

Journal of Immunology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25821220%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

volume

194

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7 June 2020

issue

9

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7 June 2020

page(s)

4362-4370

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25821220%20AND%20SRC:MED&resulttype=core&format=json

Cytotoxic-T-lymphocyte antigen 4 receptor signaling for lymphocyte adhesion is mediated by C3G and Rap1

7 June 2020

cites work

1 reference

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Diacylglycerol kinase ζ limits the generation of natural regulatory T cells

27 July 2018

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The adaptor protein Crk in immune response

27 July 2018

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Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota

27 July 2018

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Foxp3(+) regulatory T cells, immune stimulation and host defence against infection

27 July 2018

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Cell-autonomous and -non-autonomous roles of CTLA-4 in immune regulation

27 July 2018

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T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse

27 July 2018

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Conditional deletion of SLP-76 in mature T cells abrogates peripheral immune responses

27 July 2018

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A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity

27 July 2018

1 reference

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Loss of tonic T-cell receptor signals alters the generation but not the persistence of CD8+ memory T cells

27 July 2018

1 reference

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ZAP-70: an essential kinase in T-cell signaling

27 July 2018

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Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance

27 July 2018

1 reference

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A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity

27 July 2018

1 reference

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Impact of the TCR signal on regulatory T cell homeostasis, function, and trafficking

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402269

Cutting edge: regulatory T cells do not require stimulation through their TCR to suppress

27 July 2018

1 reference

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Analysis of adhesion molecules, target cells, and role of IL-2 in human FOXP3+ regulatory T cell suppressor function

27 July 2018

1 reference

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CTLA-4 control over Foxp3+ regulatory T cell function

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402269

The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activation of Rap1.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402269

Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402269

Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss

27 July 2018

1 reference

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Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin mediated human T-cell adhesion

27 July 2018

1 reference

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Regulation of T-cell antigen receptor-mediated inside-out signaling by cytosolic adapter proteins and Rap1 effector molecules

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402269

Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402269

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402269

The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402269

Cytotoxic T lymphocyte antigen-4-dependent down-modulation of costimulatory molecules on dendritic cells in CD4+ CD25+ regulatory T-cell-mediated suppression

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402269

CTLA-4 up-regulation of lymphocyte function-associated antigen 1 adhesion and clustering as an alternate basis for coreceptor function

27 July 2018

1 reference

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Regulation of the small GTPase Rap1 and extracellular signal-regulated kinases by the costimulatory molecule CTLA-4.

27 July 2018

1 reference

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Natural regulatory T cells in infectious disease

27 July 2018

1 reference

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CD25+ CD4+ T cells compete with naive CD4+ T cells for IL-2 and exploit it for the induction of IL-10 production.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402269

CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation

27 July 2018

1 reference

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Interleukin-2 is essential for CD4+CD25+ regulatory T cell function

27 July 2018

1 reference

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Rap1-mediated lymphocyte function-associated antigen-1 activation by the T cell antigen receptor is dependent on phospholipase C-gamma1

27 July 2018

1 reference

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Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402269

Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zeta

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402269

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402269

Signal transduction by the TCR for antigen

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402269

Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402269

Bcl-XL and Bcl-2 repress a common pathway of cell death

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402269

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402269

Continuous T cell receptor signals maintain a functional regulatory T cell pool.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402269

Continuous requirement for the TCR in regulatory T cell function

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402269

Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402269

Ablation of SLP-76 signaling after T cell priming generates memory CD4 T cells impaired in steady-state and cytokine-driven homeostasis.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402269

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402269

Complementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402269

CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402269

Disruption of diacylglycerol metabolism impairs the induction of T cell anergy.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402269

Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402269

Enhanced T cell responses due to diacylglycerol kinase zeta deficiency

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402269

Negative regulation of T cell antigen receptor-mediated Crk-L-C3G signaling and cell adhesion by Cbl-b.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402269

CTLA-4-Ig regulates tryptophan catabolism in vivo.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402269

Coupling of the TCR to integrin activation by Slap-130/Fyb.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402269

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4402269

Control of intestinal inflammation by regulatory T cells

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25821220

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Origin of regulatory T cells with known specificity for antigen

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25821220

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25821220

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.4049/JIMMUNOL.1402384

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25821220%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25821220%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

25821220

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25821220%20AND%20SRC:MED&resulttype=core&format=json