High Throughput Screen Identifies Natural Product Inhibitor of Phenylalanyl-tRNA Synthetase from Pseudomonas aeruginosa and Streptococcus pneumoniae. (Q35544892)

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scientific article published on January 2014

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English	High Throughput Screen Identifies Natural Product Inhibitor of Phenylalanyl-tRNA Synthetase from Pseudomonas aeruginosa and Streptococcus pneumoniae.	scientific article published on January 2014

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25601215%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

High Throughput Screen Identifies Natural Product Inhibitor of Phenylalanyl-tRNA Synthetase from Pseudomonas aeruginosa and Streptococcus pneumoniae (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25601215%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Streptococcus pneumoniae

1 reference

based on heuristic

inferred from title

natural product

1 reference

based on heuristic

inferred from title

Pseudomonas aeruginosa

1 reference

based on heuristic

inferred from title

James M Bullard

4

1 reference

Europe PubMed Central

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28 February 2020

object named as

Yanmei Hu

1

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ORCID Public Data File 2021

author name string

Stephanie O Palmer

2

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Europe PubMed Central

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28 February 2020

Hector Munoz

3

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28 February 2020

publication date

1 January 2014

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28 February 2020

Current Drug Discovery Technologies

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28 February 2020

11

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28 February 2020

4

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28 February 2020

279-292

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Europe PubMed Central

PMC publication ID

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28 February 2020

The Role of a Novel Auxiliary Pocket in Bacterial Phenylalanyl-tRNA Synthetase Druggability

1 reference

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The pneumococcus: epidemiology, microbiology, and pathogenesis

1 reference

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In vitro activity of ceftaroline against multidrug-resistant Staphylococcus aureus and Streptococcus pneumoniae: a review of published studies and the AWARE Surveillance Program (2008-2010).

1 reference

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Summary of ceftaroline activity against pathogens in the United States, 2010: report from the Assessing Worldwide Antimicrobial Resistance Evaluation (AWARE) surveillance program

1 reference

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Natural products as sources of new drugs over the 30 years from 1981 to 2010

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27 July 2018

Observations on screening-based research and some concerning trends in the literature

1 reference

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Discovery and analysis of 4H-pyridopyrimidines, a class of selective bacterial protein synthesis inhibitors

1 reference

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27 July 2018

Rational protein engineering in action: the first crystal structure of a phenylalanine tRNA synthetase from Staphylococcus haemolyticus

1 reference

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27 July 2018

Multidrug-resistant Streptococcus pneumoniae infections: current and future therapeutic options.

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27 July 2018

Natural products--the future scaffolds for novel antibiotics?

1 reference

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27 July 2018

A series of spirocyclic analogues as potent inhibitors of bacterial phenylalanyl-tRNA synthetases

1 reference

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27 July 2018

New class of bacterial phenylalanyl-tRNA synthetase inhibitors with high potency and broad-spectrum activity

1 reference

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The glycosylation of airway mucins in cystic fibrosis and its relationship with lung infection by Pseudomonas aeruginosa.

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27 July 2018

Review of the incidence and prognosis of Pseudomonas aeruginosa infections in cancer patients in the 1990s

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27 July 2018

Low dose gossypol for male contraception

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27 July 2018

Antipseudomonal antibiotics.

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27 July 2018

High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection.

1 reference

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27 July 2018

Expression and characterization of a human mitochondrial phenylalanyl-tRNA synthetase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439361

27 July 2018

Crystal structures of phenylalanyl-tRNA synthetase complexed with phenylalanine and a phenylalanyl-adenylate analogue

1 reference

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27 July 2018

Gossypol: reasons for its failure to be accepted as a safe, reversible male antifertility drug

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439361

27 July 2018

Aminoacyl-tRNA synthetases in biology and disease: new evidence for structural and functional diversity in an ancient family of enzymes.

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27 July 2018

The crystal structure of phenylalanyl-tRNA synthetase from thermus thermophilus complexed with cognate tRNAPhe

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27 July 2018

Structure of phenylalanyl-tRNA synthetase from Thermus thermophilus

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27 July 2018

Eleven down and nine to go.

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27 July 2018

Inhibitory effect of gossypol on microorganisms

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27 July 2018

Phenylalanyl-tRNA synthetase from Escherichia coli K10. Synergistic coupling between the sites for binding of L-phenylalanine and ATP.

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27 July 2018

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

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27 July 2018

Inactivation of human immunodeficiency virus in vitro by gossypol

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27 July 2018

Partition of tRNA synthetases into two classes based on mutually exclusive sets of sequence motifs

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Pneumococcal resistance to antibiotics

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Structural and functional relationships between aminoacyl-tRNA synthetases

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Determination of recognition nucleotides for Escherichia coli phenylalanyl-tRNA synthetase

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Study of protein synthesis in rat liver mitochondria use of cycloheximide

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27 July 2018

Yeast Phenylalanyl-tRNA Synthetase. Affinity and Photoaffinity Labelling of the Stereospecific Binding Sites

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27 July 2018

Mechanism of phenylalanyl-tRNA synthetase of Escherichia coli K 10. Modulation of catalytic properties by magnesium

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Idiosyncrasy and identity in the prokaryotic phe-system: Crystal structure ofE. coliphenylalanyl-tRNA synthetase complexed with phenylalanine and AMP

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26 September 2018

The crystal structure of the ternary complex of phenylalanyl-tRNA synthetase with tRNAPhe and a phenylalanyl-adenylate analogue reveals a conformational switch of the CCA end.

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Discovery and optimisation of potent, selective, ethanolamine inhibitors of bacterial phenylalanyl tRNA synthetase

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Non-standard amino acid recognition by Escherichia coli leucyl-tRNA synthetase.

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A homogeneous method to measure aminoacyl-tRNA synthetase aminoacylation activity using scintillation proximity assay technology

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12 December 2020

based on heuristic

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A series of heterocyclic inhibitors of phenylalanyl-tRNA synthetases with antibacterial activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/25601215

12 December 2020

based on heuristic

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Identifiers

10.2174/1570163812666150120154701

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25601215%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

PMC publication ID

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Europe PubMed Central

PMC publication ID

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28 February 2020

PubMed publication ID

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25601215%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

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