When protein destruction runs amok, malignancy is on the loose (Q35571368)

8 August 2017

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title

When protein destruction runs amok, malignancy is on the loose (English)

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8 August 2017

Michele Pagano

1

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8 August 2017

Ramla Benmaamar

series ordinal

2

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8 August 2017

language of work or name

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1 October 2003

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8 August 2017

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8 August 2017

volume

4

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8 August 2017

issue

4

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8 August 2017

page(s)

251-256

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The proteasome: structure, function, and role in the cell

8 August 2017

cites work

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7 January 2021

The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity

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7 January 2021

Cell cycle. Order from destruction

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7 January 2021

Oncogenic activation of c-Myb by carboxyl-terminal truncation leads to decreased proteolysis by the ubiquitin-26S proteasome pathway

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7 January 2021

Deregulated degradation of the cdk inhibitor p27 and malignant transformation.

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7 January 2021

Translocations involving c-myc and c-myc function

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7 January 2021

Inhibiting the p53-MDM2 interaction: an important target for cancer therapy

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7 January 2021

Drug-induced ubiquitylation and degradation of ErbB receptor tyrosine kinases: implications for cancer therapy

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7 January 2021

The von Hippel-Lindau tumor suppressor complex and regulation of hypoxia-inducible transcription

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7 January 2021

Gankyrin is an ankyrin-repeat oncoprotein that interacts with CDK4 kinase and the S6 ATPase of the 26 S proteasome

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7 January 2021

Amplification of chromosome 5p correlates with increased expression of Skp2 in HPV-immortalized keratinocytes.

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7 January 2021

Degradation of p27(Kip) cdk inhibitor triggered by Kaposi's sarcoma virus cyclin-cdk6 complex

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7 January 2021

Protein truncation is required for the activation of the c-myb proto-oncogene

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7 January 2021

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Molecular mechanisms of novel therapeutic approaches for multiple myeloma

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7 January 2021

Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas

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7 January 2021

A license to kill: transcriptional activation and enhanced turnover of Myc by the SCF(kp2) ubiquitin ligase

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7 January 2021

Molecular basis of the VHL hereditary cancer syndrome

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7 January 2021

Protein degradation: four E3s for the notch pathway

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7 January 2021

Imaging 26S proteasome activity and inhibition in living mice

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7 January 2021

Hereditary colorectal cancer

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7 January 2021

Modulation of p27(Kip1) levels by the cyclin encoded by Kaposi's sarcoma-associated herpesvirus

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7 January 2021

The p53 and Mdm2 families in cancer.

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7 January 2021

Biological activities and molecular targets of the human papillomavirus E7 oncoprotein

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7 January 2021

Escape from Cbl-mediated downregulation: a recurrent theme for oncogenic deregulation of receptor tyrosine kinases

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7 January 2021

Emi1 proteolysis: how SCF(beta-Trcp1) helps to activate the anaphase-promoting complex.

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7 January 2021

p27(Kip1): regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer.

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7 January 2021

Mechanisms underlying ubiquitination

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7 January 2021

The oncogenic activation of beta-catenin

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7 January 2021

Casein kinase 1: a Wnt'er of disconnect

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7 January 2021

Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex

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7 January 2021

Clinical update: proteasome inhibitors in hematologic malignancies

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7 January 2021

The two faces of transforming growth factor beta in carcinogenesis

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7 January 2021

Two HIFs may be better than one.

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7 January 2021

Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain

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7 January 2021

BRCA1-independent ubiquitination of FANCD2

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7 January 2021

Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma

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7 January 2021

Stabilization of p53 by CP-31398 inhibits ubiquitination without altering phosphorylation at serine 15 or 20 or MDM2 binding.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900243-5

7 January 2021

Ubiquitination and deubiquitination: targeting of proteins for degradation by the proteasome

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900243-5

7 January 2021

A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers.

1 reference

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7 January 2021

10.1016/S1535-6108(03)00243-5

Identifiers

DOI

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8 August 2017

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