The mammalian basic helix-loop-helix/PAS family of transcriptional regulators (Q35595674)

9 August 2017

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title

The mammalian basic helix-loop-helix/PAS family of transcriptional regulators (English)

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9 August 2017

Robyn J Kewley

1

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9 August 2017

Murray L Whitelaw

series ordinal

2

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9 August 2017

Anne Chapman-Smith

series ordinal

3

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9 August 2017

publication date

1 February 2004

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International Journal of Biochemistry & Cell Biology

9 August 2017

published in

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9 August 2017

volume

36

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9 August 2017

issue

2

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9 August 2017

page(s)

189-204

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Developmental expression of two members of a new class of transcription factors: II. Expression of aryl hydrocarbon receptor nuclear translocator in the C57BL/6N mouse embryo.

9 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Structure and Interactions of PAS Kinase N-Terminal PAS Domain

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Constitutive function of the basic helix-loop-helix/PAS factor Arnt. Regulation of target promoters via the E box motif

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Distinct roles of the molecular chaperone hsp90 in modulating dioxin receptor function via the basic helix-loop-helix and PAS domains

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Structure and expression of the Ah receptor repressor gene

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Functional characterization of DNA-binding domains of the subunits of the heterodimeric aryl hydrocarbon receptor complex imputing novel and canonical basic helix-loop-helix protein-DNA interactions.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

1.4 A structure of photoactive yellow protein, a cytosolic photoreceptor: unusual fold, active site, and chromophore

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

The crystal structure of an intact human Max-DNA complex: new insights into mechanisms of transcriptional control

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Oxygen sensing and molecular adaptation to hypoxia

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Ligand-dependent interaction of the aryl hydrocarbon receptor with a novel immunophilin homolog in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Tissue specific expression of the rat Ah-receptor and ARNT mRNAs

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Mice trisomic for a bacterial artificial chromosome with the single-minded 2 gene (Sim2) show phenotypes similar to some of those present in the partial trisomy 16 mouse models of Down syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Remembrance of things PAS: regulation of development by bHLH-PAS proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Control of cell lineage-specific development and transcription by bHLH-PAS proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

In vitro analysis of Ah receptor domains involved in ligand-activated DNA recognition

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

A Nuclear Localization Signal of Human Aryl Hydrocarbon Receptor Nuclear Translocator/Hypoxia-inducible Factor 1β Is a Novel Bipartite Type Recognized by the Two Components of Nuclear Pore-targeting Complex

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Crystal structure of transcription factor E47: E-box recognition by a basic region helix-loop-helix dimer

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Two new members of the murine Sim gene family are transcriptional repressors and show different expression patterns during mouse embryogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Structure, function, and dynamics of the dimerization and DNA-binding domain of oncogenic transcription factor v-Myc

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Structure of a biological oxygen sensor: a new mechanism for heme-driven signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Sim2 mutants have developmental defects not overlapping with those of Sim1 mutants

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

The hypoxic response: huffing and HIFing

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt)

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Profound obesity associated with a balanced translocation that disrupts the SIM1 gene

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Defective development of secretory neurones in the hypothalamus of Arnt2-knockout mice

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

The basic helix-loop-helix domain of the aryl hydrocarbon receptor nuclear transporter (ARNT) can oligomerize and bind E-box DNA specifically

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS protein (BMAL1) and identification of alternatively spliced variants with alternative translation initiation site usage

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Nuclear localization and export signals of the human aryl hydrocarbon receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Evidence that the co-chaperone p23 regulates ligand responsiveness of the dioxin (Aryl hydrocarbon) receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 (Arnt2) gene reveals partial redundancy with Arnt

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

CBP/p300 functions as a possible transcriptional coactivator of Ah receptor nuclear translocator (Arnt).

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

MOLMOL: a program for display and analysis of macromolecular structures

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

ARNT-deficient mice and placental differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Portosystemic shunting and persistent fetal vascular structures in aryl hydrocarbon receptor-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

A redox mechanism controls differential DNA binding activities of hypoxia-inducible factor (HIF) 1alpha and the HIF-like factor.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Multiple roles of ligand in transforming the dioxin receptor to an active basic helix-loop-helix/PAS transcription factor complex with the nuclear protein Arnt

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Function and regulation of the transcription factors of the Myc/Max/Mad network

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Crystal structure of MyoD bHLH domain-DNA complex: perspectives on DNA recognition and implications for transcriptional activation

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Hepatitis B virus X-associated protein 2 is a subunit of the unliganded aryl hydrocarbon receptor core complex and exhibits transcriptional enhancer activity

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Sim1 haploinsufficiency causes hyperphagia, obesity and reduction of the paraventricular nucleus of the hypothalamus

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

ARNT2 acts as the dimerization partner of SIM1 for the development of the hypothalamus

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Identification of a novel mechanism of regulation of Ah (dioxin) receptor function

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

The murine Sim-2 gene product inhibits transcription by active repression and functional interference

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline development

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

A point mutation responsible for defective function of the aryl-hydrocarbon-receptor nuclear translocator in mutant Hepa-1c1c7 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1alpha.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Cloning of mouse BMAL2 and its daily expression profile in the suprachiasmatic nucleus: a remarkable acceleration of Bmal2 sequence divergence after Bmal gene duplication

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Circadian rhythms from flies to human

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Photoactive yellow protein: a structural prototype for the three-dimensional fold of the PAS domain superfamily.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Role of the PAS domain in regulation of dimerization and DNA binding specificity of the dioxin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Identification of functional domains of the aryl hydrocarbon receptor nuclear translocator protein (ARNT)

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Comparative toxicology and mechanism of action of polychlorinated dibenzo-p-dioxins and dibenzofurans

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Alternative splicing yields novel BMAL2 variants: tissue distribution and functional characterization

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Possible function of Ah receptor nuclear translocator (Arnt) homodimer in transcriptional regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Expression and subcellular localization of the aryl hydrocarbon receptor nuclear translocator (ARNT) protein in mouse and chicken over developmental time

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

A mutation in the aryl hydrocarbon receptor (AHR) in a cultured mammalian cell line identifies a novel region of AHR that affects DNA binding

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

DNA Binding Specificities and Pairing Rules of the Ah Receptor, ARNT, and SIM Proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Identification of transactivation and repression functions of the dioxin receptor and its basic helix-loop-helix/PAS partner factor Arnt: inducible versus constitutive modes of regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Heat shock protein hsp90 regulates dioxin receptor function in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

The PAS domain confers target gene specificity of Drosophila bHLH/PAS proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900211-5

7 January 2021

10.1016/S1357-2725(03)00211-5

Identifiers

DOI

1 reference

9 August 2017

1 reference