Quantitative PK-PD model-based translational pharmacology of a novel kappa opioid receptor antagonist between rats and humans (Q35595776)

9 August 2017

title

Quantitative PK-PD model-based translational pharmacology of a novel kappa opioid receptor antagonist between rats and humans (English)

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9 August 2017

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Cheng Chang

1

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9 August 2017

Wonkyung Byon

2

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9 August 2017

Yifeng Lu

3

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9 August 2017

Leslie K Jacobsen

4

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9 August 2017

Lori L Badura

5

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9 August 2017

Aarti Sawant-Basak

6

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9 August 2017

Emily Miller

7

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9 August 2017

Jing Liu

8

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9 August 2017

Sarah Grimwood

9

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9 August 2017

Ellen Q Wang

10

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9 August 2017

Tristan S Maurer

11

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9 August 2017

language of work or name

English

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publication date

17 August 2011

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9 August 2017

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9 August 2017

volume

13

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9 August 2017

issue

4

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9 August 2017

page(s)

565-575

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Design and discovery of a selective small molecule κ opioid antagonist (2-methyl-N-((2'-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine, PF-4455242).

9 August 2017

cites work

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Scaling pharmacodynamics from in vitro and preclinical animal studies to humans

12 July 2018

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Development of translational pharmacokinetic-pharmacodynamic models

12 July 2018

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Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research.

12 July 2018

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Pharmacokinetics and pharmacodynamics of seven opioids in P-glycoprotein-competent mice: assessment of unbound brain EC50,u and correlation of in vitro, preclinical, and clinical data

12 July 2018

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Clinical attrition due to biased preclinical assessments of potential efficacy.

12 July 2018

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Whole-body physiologically based pharmacokinetic models

12 July 2018

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Population pharmacokinetic/pharmacodynamic modeling of systemic corticosteroid inhibition of whole blood lymphocytes: modeling interoccasion pharmacodynamic variability

12 July 2018

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Why drugs fail--a study on side effects in new chemical entities.

12 July 2018

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Pharmacokinetic/pharmacodynamic studies in drug product development

12 July 2018

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The effects of spiradoline (U-62066E), a kappa-opioid receptor agonist, on neuroendocrine function in man

12 July 2018

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Comparative pharmacodynamics of eight calcium channel blocking agents in Japanese essential hypertensive patients

12 July 2018

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Metabolic Clearance and Secretion Rates of Prolactin in the Rat

12 July 2018

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Effects of a kappa-opioid agonist on adrenocorticotropic and diuretic function in man.

12 July 2018

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Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats

12 July 2018

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Neuroendocrine [corrected] regulation of prolactin release

12 July 2018

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Mechanism of diuretic action of spiradoline (U-62066E)-a kappa opioid receptor agonist in the human

12 July 2018

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Prediction of hepatic extraction ratio from in vitro measurement of intrinsic clearance

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231851

Pharmacological characterization of 2-methyl-N-((2'-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine (PF-04455242), a high-affinity antagonist selective for κ-opioid receptors

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231851

Interspecies comparisons of pharmacokinetics and pharmacodynamics of recombinant human erythropoietin.

26 September 2018

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Use of plasma and brain unbound fractions to assess the extent of brain distribution of 34 drugs: comparison of unbound concentration ratios to in vivo p-glycoprotein efflux ratios

26 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231851

Modeling and allometric scaling of s(+)-ketoprofen pharmacokinetics and pharmacodynamics: a retrospective analysis

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231851

Dose Equivalency Evaluation of Major Corticosteroids: Pharmacokinetics and Cell Trafficking and Cortisol Dynamics

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231851

Evaluating pharmacokinetic/pharmacodynamic models using the posterior predictive check

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231851

Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231851

Pharmacokinetic Studies of Highly Purified Human Prolactin in Normal Human Subjects*

26 September 2018

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12 December 2020

Neuroendocrine and behavioral effects of the selective kappa agonist spiradoline in Tourette's syndrome: A pilot study

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12 December 2020

Allometric scaling of pharmacodynamic responses: application to 5-Ht1A receptor mediated responses from rat to man

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12 December 2020

Prediction of human pharmacokinetics from preclinical information: comparative accuracy of quantitative prediction approaches

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12 December 2020

Effects of E-2078, a stable dynorphin A(1-8) analog, on sedation and serum prolactin levels in rhesus monkeys

1 reference

12 December 2020

10.1208/S12248-011-9296-3

Identifiers

DOI

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Dimensions Publication ID

9 August 2017

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9 August 2017

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