The mTOR inhibitor rapamycin down-regulates the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells (Q35605737)

9 August 2017

title

The mTOR inhibitor rapamycin down-regulates the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells (English)

1 reference

Correction to: The mTOR inhibitor rapamycin down-regulates the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells.

9 August 2017

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corrigendum / erratum

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author name string

Ma'anit Shapira

1

1 reference

9 August 2017

Eli Kakiashvili

2

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9 August 2017

Tzur Rosenberg

3

1 reference

9 August 2017

Dan D Hershko

4

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9 August 2017

publication date

1 January 2006

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9 August 2017

published in

Breast Cancer Research

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9 August 2017

volume

8

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9 August 2017

issue

4

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9 August 2017

page(s)

R46

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The expression of the ubiquitin ligase subunit Cks1 in human breast cancer

9 August 2017

cites work

1 reference

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12 July 2018

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Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation

12 July 2018

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Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer

12 July 2018

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Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex

12 July 2018

1 reference

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Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1779462

Determinants of rapamycin sensitivity in breast cancer cells

12 July 2018

1 reference

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Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase

12 July 2018

1 reference

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Elevated Skp2 protein expression in human prostate cancer: association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival.

12 July 2018

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PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

12 July 2018

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PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

12 July 2018

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Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma

12 July 2018

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Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

12 July 2018

1 reference

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Role of PI3K signaling in survival and progression of LNCaP prostate cancer cells to the androgen refractory state

12 July 2018

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Linking molecular therapeutics to molecular diagnostics: inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo

12 July 2018

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p27 Kip1 inhibits HER2/neu-mediated cell growth and tumorigenesis

12 July 2018

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The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

12 July 2018

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Skp2 is oncogenic and overexpressed in human cancers

12 July 2018

1 reference

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BCR/ABL regulates expression of the cyclin-dependent kinase inhibitor p27Kip1 through the phosphatidylinositol 3-Kinase/AKT pathway

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1779462

The multiple roles of PTEN in tumor suppression

12 July 2018

1 reference

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SCF and Cullin/Ring H2-based ubiquitin ligases

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1779462

p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1779462

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1779462

The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1779462

Translational control of p27Kip1 accumulation during the cell cycle

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1779462

Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1779462

p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1779462

ras oncogenes in human cancer: a review

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1779462

Akt activation by estrogen in estrogen receptor-negative breast cancer cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1779462

Inverse relation between levels of p27(Kip1) and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16859513

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

ErbB2/neu kinase modulates cellular p27(Kip1) and cyclin D1 through multiple signaling pathways

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16859513

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/BCR1533

1 reference

Dimensions Publication ID

9 August 2017

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1 reference

9 August 2017

1 reference