Secreted beta-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosphorylation. (Q35616076)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8041753%20AND%20SRC:MED&resulttype=core&format=json

23 October 2019

title

Secreted beta-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosphorylation (English)

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23 October 2019

1 reference

4

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23 October 2019

author name string

S M Greenberg

1

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23 October 2019

E H Koo

2

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23 October 2019

D J Selkoe

3

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23 October 2019

K S Kosik

5

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23 October 2019

language of work or name

English

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publication date

1 July 1994

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8041753%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

23 October 2019

published in

1 reference

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23 October 2019

volume

91

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23 October 2019

issue

15

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23 October 2019

page(s)

7104-7108

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Protein measurement with the Folin phenol reagent

23 October 2019

cites work

1 reference

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The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development

12 July 2018

1 reference

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Amyloid precursor protein in the cerebral cortex is rapidly and persistently induced by loss of subcortical innervation

12 July 2018

1 reference

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Extracellular signal regulated kinases. Localization of protein and mRNA in the human hippocampal formation in Alzheimer's disease

12 July 2018

1 reference

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p44mpk MAP kinase induces aizheimer type alterations in tau function and in primary hippocampal neurons

12 July 2018

1 reference

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Sodium-phosphate cotransport in human red blood cells. Kinetics and role in membrane metabolism

12 July 2018

1 reference

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Amyloid beta protein enhances the survival of hippocampal neurons in vitro

12 July 2018

1 reference

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Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

12 July 2018

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The regulation of amyloid beta protein precursor secretion and its modulatory role in cell adhesion

12 July 2018

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Protease nexin-II, a potent antichymotrypsin, shows identity to amyloid beta-protein precursor

12 July 2018

1 reference

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The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II.

12 July 2018

1 reference

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Epitopes that span the tau molecule are shared with paired helical filaments.

12 July 2018

1 reference

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Secreted form of amyloid beta protein precursor is involved in the growth regulation of fibroblasts.

12 July 2018

1 reference

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Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides

12 July 2018

1 reference

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Trophic effect of beta-amyloid precursor protein on cerebral cortical neurons in culture

12 July 2018

1 reference

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Secretion of the beta/A4 amyloid precursor protein. Identification of a cleavage site in cultured mammalian cells

12 July 2018

1 reference

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A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

12 July 2018

1 reference

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An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=44347

Antibodies to non-beta regions of the beta-amyloid precursor protein detect a subset of senile plaques

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=44347

Defined neurofilament, tau, and beta-amyloid precursor protein epitopes distinguish Alzheimer from non-Alzheimer senile plaques.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=44347

Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=44347

The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth

12 July 2018

1 reference

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Alzheimer's disease: a cell biological perspective

12 July 2018

1 reference

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Familial Alzheimer's disease with the amyloid precursor protein position 717 mutation and sporadic Alzheimer's disease have the same cytoskeletal pathology.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=44347

The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=44347

Protein sequence and mass spectrometric analyses of tau in the Alzheimer's disease brain

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=44347

Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=44347

Tau pathology in a case of familial Alzheimer's disease with a valine to glycine mutation at position 717 in the amyloid precursor protein

12 July 2018

1 reference

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Amyloid precursor protein accumulates in regions of neurodegeneration following focal cerebral ischemia in the rat

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=44347

Amyloid precursor protein is localized in growing neurites of neonatal rat brain

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=44347

Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=44347

A calcium-stimulated serine protease from monkey brain degrades the beta-amyloid precursor protein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=44347

Phosphorylation-dependent epitopes of neurofilament antibodies on tau protein and relationship with Alzheimer tau

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=44347

Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=44347

Bacterial expression, purification, and functional mapping of the amyloid beta/A4 protein precursor

12 July 2018

1 reference

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Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau.

12 July 2018

1 reference

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p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected]

12 July 2018

1 reference

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Mitogen-activated protein kinases: versatile transducers for cell signaling

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=44347

Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer's disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=44347

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=44347

Synthetic amyloid beta-protein fails to produce specific neurotoxicity in monkey cerebral cortex

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=44347

Brain protein kinase PK40erk converts TAU into a PHF-like form as found in Alzheimer's disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=44347

Functional studies of Alzheimer's disease tau protein

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=44347

Localization of the mitogen activated protein kinase ERK2 in Alzheimer's disease neurofibrillary tangles and senile plaque neurites

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=44347

Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=44347

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=44347

Expression of beta-amyloid precursor protein in reactive astrocytes following neuronal damage

25 September 2018

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12 December 2020

Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases

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12 December 2020

In vivo phosphorylation sites in fetal and adult rat tau

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12 December 2020

The amyloid precursor protein is developmentally regulated and correlated with synaptogenesis

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12 December 2020

Identifiers

DOI

10.1073/PNAS.91.15.7104

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8041753%20AND%20SRC:MED&resulttype=core&format=json

23 October 2019

0 references

release_kwe5esrhpze5njwfnw22uxgnfy

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/kwe5esrhpze5njwfnw22uxgnfy

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8041753%20AND%20SRC:MED&resulttype=core&format=json

23 October 2019

PubMed publication ID

8041753

1 reference