dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants (Q35616117)

25827226

9 August 2017

title

dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants (English)

1 reference

9 August 2017

5

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7 June 2020

Andrei Chabes

6

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7 June 2020

author name string

Lindsey N Williams

1

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7 June 2020

Lisette Marjavaara

2

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7 June 2020

Gary M Knowels

3

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7 June 2020

Eric M Schultz

4

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7 June 2020

Alan J Herr

7

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7 June 2020

language of work or name

English

0 references

publication date

31 March 2015

1 reference

25827226

Proceedings of the National Academy of Sciences of the United States of America

9 August 2017

published in

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7 June 2020

volume

112

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7 June 2020

issue

19

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7 June 2020

page(s)

E2457-66

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Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity

7 June 2020

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12 July 2018

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Ixr1 is required for the expression of the ribonucleotide reductase Rnr1 and maintenance of dNTP pools

12 July 2018

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Sensing of replication stress and Mec1 activation act through two independent pathways involving the 9-1-1 complex and DNA polymerase ε

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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The ribonucleotide reductase inhibitor, Sml1, is sequentially phosphorylated, ubiquitylated and degraded in response to DNA damage

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Mrc1 phosphorylation in response to DNA replication stress is required for Mec1 accumulation at the stalled fork

12 July 2018

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12 July 2018

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12 July 2018

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Dif1 controls subcellular localization of ribonucleotide reductase by mediating nuclear import of the R2 subunit

12 July 2018

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12 July 2018

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Yeast DNA polymerase epsilon participates in leading-strand DNA replication

12 July 2018

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Maintenance of fork integrity at damaged DNA and natural pause sites

12 July 2018

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A novel function of DNA polymerase zeta regulated by PCNA.

12 July 2018

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12 July 2018

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Regulation of mammalian ribonucleotide reduction and dNTP pools after DNA damage and in resting cells

12 July 2018

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12 July 2018

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12 July 2018

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Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53.

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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A ribonucleotide reductase gene is a transcriptional target of p53 and p73

12 July 2018

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EXO1 and MSH6 are high-copy suppressors of conditional mutations in the MSH2 mismatch repair gene of Saccharomyces cerevisiae

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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The 3'-->5' exonucleases of DNA polymerases delta and epsilon and the 5'-->3' exonuclease Exo1 have major roles in postreplication mutation avoidance in Saccharomyces cerevisiae

12 July 2018

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A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools

12 July 2018

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Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway

12 July 2018

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The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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RAD9, RAD17, and RAD24 are required for S phase regulation in Saccharomyces cerevisiae in response to DNA damage.

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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DUN1 encodes a protein kinase that controls the DNA damage response in yeast

12 July 2018

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The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast

12 July 2018

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DNA polymerase epsilon links the DNA replication machinery to the S phase checkpoint

12 July 2018

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A positive selection for mutants lacking orotidine-5'-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance

12 July 2018

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Errors in DNA replication as a basis of malignant changes

12 July 2018

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Comparison between DNA melting thermodynamics and DNA polymerase fidelity

12 July 2018

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Identification and isolation of the gene encoding the small subunit of ribonucleotide reductase from Saccharomyces cerevisiae: DNA damage-inducible gene required for mitotic viability

12 July 2018

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Kinetic mechanism whereby DNA polymerase I (Klenow) replicates DNA with high fidelity

12 July 2018

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Interactions between deoxyribonucleotide and DNA synthesis

12 July 2018

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Extension of mismatched 3' termini of DNA is a major determinant of the infidelity of human immunodeficiency virus type 1 reverse transcriptase.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434706

Two genes differentially regulated in the cell cycle and by DNA-damaging agents encode alternative regulatory subunits of ribonucleotide reductase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434706

S-Phase-specific expression of mammalian ribonucleotide reductase R1 and R2 subunit mRNAs

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434706

Eukaryotic DNA polymerase amino acid sequence required for 3'----5' exonuclease activity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434706

Strand-specific analysis shows protein binding at replication forks and PCNA unloading from lagging strands when forks stall

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434706

Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434706

A note on plating efficiency in fluctuation experiments.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434706

Ribonucleotide reductase and mitochondrial DNA synthesis

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434706

Stimulation of mutagenesis by proportional deoxyribonucleoside triphosphate accumulation in Escherichia coli

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434706

Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductase

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434706

Suppression of spontaneous chromosomal rearrangements by S phase checkpoint functions in Saccharomyces cerevisiae

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434706

Checkpoint-dependent activation of mutagenic repair in Saccharomyces cerevisiae pol3-01 mutants

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434706

Cross-talk between the allosteric effector-binding sites in mouse ribonucleotide reductase

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434706

Base mispair extension kinetics. Comparison of DNA polymerase alpha and reverse transcriptase

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434706

Costs and Benefits of High Mutation Rates: Adaptive Evolution of Bacteria in the Mouse Gut

25 September 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1422948112

Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programs

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1422948112

Getting started with yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1422948112

Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1422948112

Differential extension of 3' mispairs is a major contribution to the high fidelity of calf thymus DNA polymerase-alpha

21 January 2018

1 reference

12 December 2020

Base analog 6-N-hydroxylaminopurine mutagenesis in the yeast Saccharomyces cerevisiae is controlled by replicative DNA polymerases

1 reference

12 December 2020

Defective DNA polymerase-delta proofreading causes cancer susceptibility in mice

1 reference

12 December 2020

Mutational meltdown in laboratory yeast populations

1 reference

12 December 2020

Molecular Genetics of Colorectal Cancer

1 reference

12 December 2020

Two-stage PCR protocol allowing introduction of multiple mutations, deletions and insertions using QuikChange Site-Directed Mutagenesis

1 reference

12 December 2020

Ploidy controls the success of mutators and nature of mutations during budding yeast evolution

1 reference

12 December 2020

COMPETITION BETWEEN HIGH AND LOW MUTATING STRAINS OF ESCHERICHIA COLI

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1422948112

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25827226%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25827226%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

25827226

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25827226%20AND%20SRC:MED&resulttype=core&format=json