Clonal expansion of T cells in abdominal aortic aneurysm: a role for doxycycline as drug of choice? (Q35723666)

9 August 2017

10 references

13 March 2019

14 March 2019

22 March 2019

17 June 2019

22 June 2019

12 October 2019

18 October 2019

7 November 2019

13 November 2019

11 September 2020

Clonal expansion of T cells in abdominal aortic aneurysm: a role for doxycycline as drug of choice? (English)

1 reference

abdominal aortic aneurysm

9 August 2017

main subject

10 references

13 March 2019

14 March 2019

22 March 2019

17 June 2019

22 June 2019

12 October 2019

18 October 2019

7 November 2019

13 November 2019

11 September 2020

1 reference

12 October 2019

hemic and immune systems

1 reference

18 October 2019

1 reference

7 November 2019

1 reference

13 November 2019

1 reference

11 September 2020

1 reference

2

Jan-Willem Taanman

1 reference

9 August 2017

Albert M Kroon

1

1 reference

9 August 2017

language of work or name

English

0 references

publication date

18 May 2015

11 references

International Journal of Molecular Sciences

9 August 2017

13 March 2019

14 March 2019

22 March 2019

17 June 2019

22 June 2019

12 October 2019

18 October 2019

7 November 2019

13 November 2019

11 September 2020

11 references

9 August 2017

13 March 2019

14 March 2019

22 March 2019

17 June 2019

22 June 2019

12 October 2019

18 October 2019

7 November 2019

13 November 2019

11 September 2020

16

1 reference

9 August 2017

issue

5

1 reference

9 August 2017

page(s)

11178-11195

1 reference

Creative Commons Attribution

9 August 2017

copyright license

10 references

13 March 2019

14 March 2019

22 March 2019

17 June 2019

22 June 2019

12 October 2019

18 October 2019

7 November 2019

13 November 2019

11 September 2020

0 references

on focus list of Wikimedia project

ScienceSource

0 references

cites work

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12 July 2018

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12 July 2018

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12 July 2018

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Endovascular repair for ruptured abdominal aortic aneurysm confers an early survival benefit over open repair

12 July 2018

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Combination therapy with atorvastatin and amlodipine suppresses angiotensin II-induced aortic aneurysm formation

12 July 2018

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12 July 2018

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12 July 2018

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A clinical evaluation of statin pleiotropy: statins selectively and dose-dependently reduce vascular inflammation

12 July 2018

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Cyclooxygenase-2 inhibition attenuates abdominal aortic aneurysm progression in hyperlipidemic mice

12 July 2018

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Non-antibacterial tetracycline formulations: clinical applications in dentistry and medicine

12 July 2018

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Doxycycline does not influence established abdominal aortic aneurysms in angiotensin II-infused mice

12 July 2018

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12 July 2018

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Mast cell chymase and tryptase in abdominal aortic aneurysm formation

12 July 2018

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Subarachnoid hemorrhage caused by ruptured intracranial fusiform aneurysm associated with microscopic polyangiitis

12 July 2018

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Novel mechanisms of abdominal aortic aneurysms

12 July 2018

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Effects of statin therapy on abdominal aortic aneurysm growth: a meta-analysis and meta-regression of observational comparative studies

12 July 2018

1 reference

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Involvement of the renin-angiotensin system in abdominal and thoracic aortic aneurysms.

12 July 2018

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Can pharmacologic agents slow abdominal aortic aneurysm growth?

12 July 2018

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Serine protease inhibitor A3 in atherosclerosis and aneurysm disease

12 July 2018

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Inhibition of EP4 signaling attenuates aortic aneurysm formation

12 July 2018

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Meta-analysis of individual patient data to examine factors affecting growth and rupture of small abdominal aortic aneurysms

12 July 2018

1 reference

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Multiple mechanisms for the action of chymase inhibitors

12 July 2018

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Calpain inhibition attenuates angiotensin II-induced abdominal aortic aneurysms and atherosclerosis in low-density lipoprotein receptor-deficient mice.

12 July 2018

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Chemically modified non-antimicrobial tetracyclines are multifunctional drugs against advanced cancers☆

12 July 2018

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Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting

12 July 2018

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12 July 2018

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A meta-analysis of clinical studies of statins for prevention of abdominal aortic aneurysm expansion

12 July 2018

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12 July 2018

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Total lymphocyte deficiency attenuates AngII-induced atherosclerosis in males but not abdominal aortic aneurysms in apoE deficient mice.

12 July 2018

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Pharmacological inhibition of BLT1 diminishes early abdominal aneurysm formation

12 July 2018

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Outcomes following endovascular vs open repair of abdominal aortic aneurysm: a randomized trial

12 July 2018

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Blocking TNF-alpha attenuates aneurysm formation in a murine model

12 July 2018

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The effect of azithromycin and Chlamydophilia pneumonia infection on expansion of small abdominal aortic aneurysms--a prospective randomized double-blind trial.

12 July 2018

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Clinical trial of doxycycline for matrix metalloproteinase-9 inhibition in patients with an abdominal aneurysm: doxycycline selectively depletes aortic wall neutrophils and cytotoxic T cells

12 July 2018

1 reference

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Membrane-type 1 matrix metalloproteinase regulates macrophage-dependent elastolytic activity and aneurysm formation in vivo

12 July 2018

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A randomized, placebo-controlled trial of doxycycline after endoluminal aneurysm repair

12 July 2018

1 reference

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Medical management of small abdominal aortic aneurysms

12 July 2018

1 reference

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The efficacy of pharmacotherapy for decreasing the expansion rate of abdominal aortic aneurysms: a systematic review and meta-analysis

12 July 2018

1 reference

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Doxycycline delays aneurysm rupture in a mouse model of Marfan syndrome

12 July 2018

1 reference

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Matrix metalloproteinase inhibitors as anticancer agents

12 July 2018

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The rupture rate of large abdominal aortic aneurysms: is this modified by anatomical suitability for endovascular repair?

12 July 2018

1 reference

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Human autoimmune diseases are specific antigen-driven T-cell diseases: identification of the antigens

12 July 2018

1 reference

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Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome

12 July 2018

1 reference

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Abdominal aortic aneurysms: an underestimated type of immune-mediated large vessel arteritis?

12 July 2018

1 reference

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Matrix metalloproteinase inhibitors as anticancer therapeutics.

12 July 2018

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Chemically modified tetracyclines as inhibitors of matrix metalloproteinases

12 July 2018

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Th2-predominant inflammation and blockade of IFN-gamma signaling induce aneurysms in allografted aortas

12 July 2018

1 reference

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Drug resistance and apoptosis in cancer treatment: development of new apoptosis-inducing agents active in drug resistant malignancies

12 July 2018

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Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome

12 July 2018

1 reference

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Use of doxycycline to decrease the growth rate of abdominal aortic aneurysms: a randomized, double-blind, placebo-controlled pilot study

12 July 2018

1 reference

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Cytotoxic activity and inhibition of tumor cell invasion by derivatives of a chemically modified tetracycline CMT-3 (COL-3).

12 July 2018

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Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice

12 July 2018

1 reference

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The antitumour effect of doxycycline on a T-cell leukaemia in the rat.

12 July 2018

1 reference

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Bioavailability of tetracycline and doxycycline in fasted and nonfasted subjects

12 July 2018

1 reference

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Regulatory T cells prevent angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E knockout mice.

12 July 2018

1 reference

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Doxycycline for stabilization of abdominal aortic aneurysms: a randomized trial

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463695

Chlamydia pneumoniae antibodies and C-reactive protein levels in patients with abdominal aortic aneurysms.

25 September 2018

1 reference

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Losartan reduces aortic dilatation rate in adults with Marfan syndrome: a randomized controlled trial

25 September 2018

1 reference

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Focal histopathological progression of porcine experimental abdominal aortic aneurysm is mitigated by atorvastatin

25 September 2018

1 reference

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Decreased tissue levels of cyclophilin A, a cyclosporine a target and phospho-ERK1/2 in simvastatin patients with abdominal aortic aneurysm

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463695

Fucoidan interferes with Porphyromonas gingivalis-induced aneurysm enlargement by decreasing neutrophil activation

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463695

Comment on: 'Effects of statin therapy on abdominal aortic aneurysm growth: a meta-analysis and meta-regression of observational comparative studies'.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463695

Prevalence, indications and appropriateness of antiplatelet therapy in patients operated for acute aortic dissection: associations with bleeding complications and mortality

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463695

Protective role of cyclooxygenase (COX)-2 in experimental lung injury: evidence of a lipoxin A4-mediated effect

25 September 2018

1 reference

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Use of angiotensin converting enzyme inhibitors is associated with increased growth rate of abdominal aortic aneurysms

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463695

Deficient CD4+CD25+ T regulatory cell function in patients with abdominal aortic aneurysms.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463695

Oral doxycycline versus intravenous ceftriaxone for European Lyme neuroborreliosis: a multicentre, non-inferiority, double-blind, randomised trial

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463695

Localized administration of doxycycline suppresses aortic dilatation in an experimental mouse model of abdominal aortic aneurysm.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463695

Statins are associated with a reduced infrarenal abdominal aortic aneurysm growth

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463695

Intravenous ceftriaxone compared with oral doxycycline for the treatment of Lyme neuroborreliosis

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463695

Treatment with simvastatin suppresses the development of experimental abdominal aortic aneurysms in normal and hypercholesterolemic mice.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463695

Continuous periaortic infusion improves doxycycline efficacy in experimental aortic aneurysms

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463695

Clinical and biochemical results of the metalloproteinase inhibition with subantimicrobial doses of doxycycline to prevent acute coronary syndromes (MIDAS) pilot trial

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463695

Membrane type I-matrix metalloproteinase (MT1-MMP) is internalised by two different pathways and is recycled to the cell surface

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463695

Differential effects of doxycycline, a broad-spectrum matrix metalloproteinase inhibitor, on angiotensin II-induced atherosclerosis and abdominal aortic aneurysms.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463695

Prolonged administration of doxycycline in patients with small asymptomatic abdominal aortic aneurysms: report of a prospective (Phase II) multicenter study.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463695

Randomized double-blind controlled trial of roxithromycin for prevention of abdominal aortic aneurysm expansion

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463695

Suppression of experimental abdominal aortic aneurysms in the rat by treatment with angiotensin-converting enzyme inhibitors

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463695

Impaired results of a randomised double blinded clinical trial of propranolol versus placebo on the expansion rate of small abdominal aortic aneurysms

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463695

Abdominal aortic aneurysm expansion rate: effect of size and beta-adrenergic blockade

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463695

Abdominal aortic aneurysms

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463695

Mast Cells in Abdominal Aortic Aneurysms

25 September 2018

1 reference

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Simvastatin Attenuates the Activity of Matrix Metalloprotease-9 in Aneurysmal Aortic Tissue

21 January 2018

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Immunosuppression and the Abdominal Aortic Aneurysm

21 January 2018

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Effectiveness of cyclooxygenase-2 inhibition in limiting abdominal aortic aneurysm progression in mice correlates with a differentiated smooth muscle cell phenotype

21 January 2018

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12 December 2020

Simvastatin decreases free radicals formation in the human abdominal aortic aneurysm wall via NF-κB

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12 December 2020

Preoperative treatment with doxycycline reduces aortic wall expression and activation of matrix metalloproteinases in patients with abdominal aortic aneurysms

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12 December 2020

Doxycycline in combination chemotherapy of a rat leukemia

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12 December 2020

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12 December 2020

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12 December 2020

Doxycycline inhibition of aneurysmal degeneration in an elastase-induced rat model of abdominal aortic aneurysm: preservation of aortic elastin associated with suppressed production of 92 kD gelatinase

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12 December 2020

Treatment with simvastatin inhibits the formation of abdominal aortic aneurysms in rabbits

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12 December 2020

Pharmacologic suppression of experimental abdominal aortic aneurysms: acomparison of doxycycline and four chemically modified tetracyclines

1 reference

12 December 2020

Doxycycline versus ceftriaxone for the treatment of patients with chronic Lyme borreliosis

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12 December 2020

Abdominal aortic aneurysm regression by medical treatment: possibility or pipe dream?

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12 December 2020

Diabetes as a negative risk factor for abdominal aortic aneurysm - does the disease aetiology or the treatment provide the mechanism of protection?

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12 December 2020

Tetracyclines induce apoptosis in osteoclasts

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12 December 2020

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12 December 2020

Doxycycline inhibits elastin degradation and reduces metalloproteinase activity in a model of aneurysmal disease

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12 December 2020

Abdominal aortic aneurysm is a specific antigen-driven T cell disease

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12 December 2020

Effect of beta-adrenergic blockade on the growth rate of abdominal aortic aneurysms

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12 December 2020

MMP inhibition in abdominal aortic aneurysms. Rationale for a prospective randomized clinical trial

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12 December 2020

Comment on "aneurysmal lesions of patients with abdominal aortic aneurysm contain clonally expanded T cells"

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12 December 2020

Doxycycline in patients with abdominal aortic aneurysms and in mice: comparison of serum levels and effect on aneurysm growth in mice

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12 December 2020

Inhibition of mitochondrial protein synthesis leads to proliferation arrest in the G1-phase of the cell cycle

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12 December 2020

Identifiers

DOI

10.3390/IJMS160511178

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9 August 2017

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9 August 2017

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