Lipoplex-mediated delivery of nucleic acids: factors affecting in vivo transfection (Q35819354)

10 August 2017

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title

Lipoplex-mediated delivery of nucleic acids: factors affecting in vivo transfection (English)

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10 August 2017

Crispin R Dass

1

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10 August 2017

publication date

23 June 2004

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Journal of Molecular Medicine

10 August 2017

published in

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10 August 2017

volume

82

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10 August 2017

issue

9

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10 August 2017

page(s)

579-591

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Antisense c-myc oligodeoxyribonucleotide cellular uptake

10 August 2017

cites work

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Interaction between DNA-cationic liposome complexes and erythrocytes is an important factor in systemic gene transfer via the intravenous route in mice: the role of the neutral helper lipid.

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In vivo characteristics of cationic liposomes as delivery vectors for gene therapy

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Plasmid DNA size does not affect the physicochemical properties of lipoplexes but modulates gene transfer efficiency

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Cationic liposome-mediated gene delivery to the liver and to hepatocellular carcinomas in mice

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Assessment of ocular irritability of liposome preparations

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Structural basis of DOTMA for its high intravenous transfection activity in mouse

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Evidence for safety and efficacy of DOTAP cationic liposome mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis

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New cationic liposomes for gene transfer into mammalian cells with high efficiency and low toxicity

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Cationic lipid-mediated gene delivery to murine lung: correlation of lipid hydration with in vivo transfection activity

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Endocytosis and intracellular processing accompanying transfection mediated by cationic liposomes

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A model for evaluating selective delivery of plasmid DNA to tumours via the vasculature

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Anti-inflammatory activity of cationic lipids

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Immune stimulation by a CpG-containing oligodeoxynucleotide is enhanced when encapsulated and delivered in lipid particles

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Interactions of mammalian cells with lipid dispersions containing novel metabolizable cationic amphiphiles

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Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors

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Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-alpha-mediated shock

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Morphogenesis of peritoneal metastasis in human gastric cancer

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Modified microplex vector enhances transfection of cells in culture while maintaining tumour-selective gene delivery in-vivo

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A placebo-controlled study of liposome-mediated gene transfer to the nasal epithelium of patients with cystic fibrosis.

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Lipoplexes and tumours. A review

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Delivery of lipoplexes for genotherapy of solid tumours: role of vascular endothelial cells

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12 December 2020

Direct gene transfer with DNA-liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans

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12 December 2020

Cationic liposomes target angiogenic endothelial cells in tumors and chronic inflammation in mice

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12 December 2020

A clinical inflammatory syndrome attributable to aerosolized lipid-DNA administration in cystic fibrosis

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Towards gene therapy for cystic fibrosis: a clinical progress report.

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Promoter attenuation in gene therapy: interferon-gamma and tumor necrosis factor-alpha inhibit transgene expression

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12 December 2020

A survey of the binding of polycationic ferritin in several fenestrated capillary beds: indication of heterogeneity in the luminal glycocalyx of fenestral diaphragms

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12 December 2020

Comparison of cell proliferation and toxicity assays using two cationic liposomes

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12 December 2020

A novel cationic lipid greatly enhances plasmid DNA delivery and expression in mouse lung

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12 December 2020

Immune response in human melanoma after transfer of an allogeneic class I major histocompatibility complex gene with DNA-liposome complexes

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12 December 2020

Efficacy of cationic liposome-mediated gene transfer to mesangial cells in vitro and in vivo

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12 December 2020

Vaxfectin enhances antigen specific antibody titers and maintains Th1 type immune responses to plasmid DNA immunization

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12 December 2020

Structural and functional analysis of cationic transfection lipids: the hydrophobic domain

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12 December 2020

Basis of pulmonary toxicity associated with cationic lipid-mediated gene transfer to the mammalian lung

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12 December 2020

Safety and toxicity of catheter gene delivery to the pulmonary vasculature in a patient with metastatic melanoma

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12 December 2020

Intraarterial delivery of adenovirus vectors and liposome-DNA complexes to experimental brain neoplasms

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12 December 2020

Novel pyridinium surfactants for efficient, nontoxic in vitro gene delivery

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12 December 2020

Targeting the prostate for destruction through a vascular address

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12 December 2020

Lipoplex-induced hemagglutination: potential involvement in intravenous gene delivery

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12 December 2020

Immunogene therapy of recurrent glioblastoma multiforme with a liposomally encapsulated replication-incompetent Semliki forest virus vector carrying the human interleukin-12 gene--a phase I/II clinical protocol.

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Regulation of in vitro gene expression using antisense oligonucleotides or antisense expression plasmids transfected using starburst PAMAM dendrimers

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12 December 2020

Liposomes containing cationic dimethyl dioctadecyl ammonium bromide: formulation, quality control, and lipofection efficiency

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12 December 2020

Intratracheal administration of interleukin 12 plasmid-cationic lipid complexes inhibits murine lung metastases

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12 December 2020

Cationic lipid:bacterial DNA complexes elicit adaptive cellular immunity in murine intraperitoneal tumor models

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12 December 2020

Development of novel cationic liposomes for efficient gene transfer into peritoneal disseminated tumor

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12 December 2020

Cation substitution in cationic phosphonolipids: a new concept to improve transfection activity and decrease cellular toxicity

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12 December 2020

Contribution of plasmid DNA to hepatotoxicity after systemic administration of lipoplexes

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12 December 2020

Gene therapy for cystic fibrosis using cationic liposome mediated gene transfer: a phase I trial of safety and efficacy in the nasal airway

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12 December 2020

The role of surface charge in the activation of the classical and alternative pathways of complement by liposomes.

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12 December 2020

Cationic liposome-mediated E1A gene transfer to human breast and ovarian cancer cells and its biologic effects: a phase I clinical trial

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12 December 2020

Fate of cationic liposomes and their complex with oligonucleotide in vivo

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12 December 2020

Non-antisense oligonucleotide approaches for experimental treatment of glioblastoma

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12 December 2020

Efficiency and toxicity of liposome-mediated gene transfer to corneal endothelial cells

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12 December 2020

Delivery and pathway in MCF7 cells of DNA vectorized by cationic liposomes derived from cholesterol

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12 December 2020

Phase I study of immunotherapy of cutaneous metastases of human carcinoma using allogeneic and xenogeneic MHC DNA-liposome complexes

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12 December 2020

Membrane perturbation and the mechanism of lipid-mediated transfer of DNA into cells

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12 December 2020

Biodistribution of radiolabeled lipid-DNA complexes and DNA in mice

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12 December 2020

The role of tissue macrophages in the induction of proinflammatory cytokine production following intravenous injection of lipoplexes

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12 December 2020

Reduced inflammatory response to plasmid DNA vectors by elimination and inhibition of immunostimulatory CpG motifs

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12 December 2020

Direct in vitro evidence and in vivo analysis of the antiangiogenesis effects of interleukin 12.

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12 December 2020

Effect of polyisobutylcyanoacrylate nanoparticles and lipofectin loaded with oligonucleotides on cell viability and PKC alpha neosynthesis in HepG2 cells

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12 December 2020

Cationic lipid binding to DNA: characterization of complex formation

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12 December 2020

Vehicles for oligonucleotide delivery to tumours

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12 December 2020

Tissue distribution of the cytofectin component of a plasmid-DNA/cationic lipid complex following intravenous administration in mice

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12 December 2020

Gene therapy for peritoneal dissemination of pancreatic cancer by liposome-mediated transfer of herpes simplex virus thymidine kinase gene

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12 December 2020

Three-Dimensional Imaging of Lipid Gene-Carriers: Membrane Charge Density Controls Universal Transfection Behavior in Lamellar Cationic Liposome-DNA Complexes

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12 December 2020

A microsphere-liposome (microplex) vector for targeted gene therapy of cancer. II. In vivo biodistribution study in a solid tumor model

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12 December 2020

Human gene therapy for malignant gliomas (glioblastoma multiforme and anaplastic astrocytoma) by in vivo transduction with human interferon beta gene using cationic liposomes

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12 December 2020

Multiple systemic expression of human interferon-beta in mice can be achieved upon repeated administration of optimized pcTG90-lipoplex

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12 December 2020

beta-Galactosidase staining following intracoronary infusion of cationic liposomes in the in vivo rabbit heart is produced by microinfarction rather than effective gene transfer: a cautionary tale

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12 December 2020

Improved DNA: liposome complexes for increased systemic delivery and gene expression

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12 December 2020

Trends in lipoplex physical properties dependent on cationic lipid structure, vehicle and complexation procedure do not correlate with biological activity

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12 December 2020

Proteoglycans mediate cationic liposome-DNA complex-based gene delivery in vitro and in vivo

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12 December 2020

Systemic administration of cationic phosphonolipids/DNA complexes and the relationship between formulation and lung transfection efficiency

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12 December 2020

Systemic Gene Expression After Intravenous DNA Delivery into Adult Mice

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12 December 2020

LPD lipopolyplex initiates a potent cytokine response and inhibits tumor growth

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12 December 2020

Safety and biological efficacy of a lipid-CFTR complex for gene transfer in the nasal epithelium of adult patients with cystic fibrosis

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12 December 2020

The inhibitory role of CpG immunostimulatory motifs in cationic lipid vector-mediated transgene expression in vivo

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12 December 2020

Distribution of anionic sites on the capillary endothelium in an experimental brain tumor model

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12 December 2020

Successful treatment of primary and disseminated human lung cancers by systemic delivery of tumor suppressor genes using an improved liposome vector

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12 December 2020

Synthesis of a single-tailed cationic lipid and investigation of its transfection

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12 December 2020

Polyinosinic acid and polycationic liposomes attenuate the hepatic clearance of circulating plasmid DNA.

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12 December 2020

Interaction of positively-charged liposomes with blood: implications for their application in vivo

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12 December 2020

Cationic lipids enhance cytokine and cell influx levels in the lung following administration of plasmid: cationic lipid complexes

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12 December 2020

Folate-targeted, cationic liposome-mediated gene transfer into disseminated peritoneal tumors

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12 December 2020

Plasmid DNA gene therapy: studies with the human interleukin-2 gene in tumor cells in vitro and in the murine B16 melanoma model in vivo.

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12 December 2020

The role of dioleoyl phosphatidylethanolamine in cationic liposome mediated gene transfer

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12 December 2020

Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations

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12 December 2020

Toxicity and immunomodulatory activity of liposomal vectors formulated with cationic lipids toward immune effector cells

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12 December 2020

Transfection of nasal mucosa with a normal alpha1-antitrypsin gene in alpha1-antitrypsin-deficient subjects: comparison with protein therapy

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12 December 2020

Repeat administration of DNA/liposomes to the nasal epithelium of patients with cystic fibrosis

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12 December 2020

Continuous low-dose anti-angiogenic/ metronomic chemotherapy: from the research laboratory into the oncology clinic

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12 December 2020

Paclitaxel encapsulated in cationic liposomes diminishes tumor angiogenesis and melanoma growth in a "humanized" SCID mouse model

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12 December 2020

Interactions of human ovarian tumor cells with human mesothelial cells grown on extracellular matrix. An in vitro model system for studying tumor cell adhesion and invasion

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12 December 2020

Effects of complement depletion on the pharmacokinetics and gene delivery mediated by cationic lipid-DNA complexes

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12 December 2020

Contribution of Plasmid DNA to Inflammation in the Lung after Administration of Cationic Lipid:pDNA Complexes

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12 December 2020

Detailed analysis of structures and formulations of cationic lipids for efficient gene transfer to the lung

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12 December 2020

Mechanism of lipoplex gene delivery in mouse lung: binding and internalization of fluorescent lipid and DNA components

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12 December 2020

Electrostatic and structural properties of complexes involving plasmid DNA and cationic lipids commonly used for gene delivery

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12 December 2020

Intravenous cytokine gene delivery by lipid-DNA complexes controls the growth of established lung metastases

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12 December 2020

Nature of linkage between the cationic headgroup and cholesteryl skeleton controls gene transfection efficiency

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12 December 2020

Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model

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12 December 2020

Development of non-viral vectors for systemic gene delivery

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12 December 2020

Organ-specific endothelial cell uptake of cationic liposome-DNA complexes in mice

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12 December 2020

A novel tetraester construct that reduces cationic lipid-associated cytotoxicity. Implications for the onset of cytotoxicity

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12 December 2020

In vivo gene therapy with a cationic polymer markedly enhances the antitumor activity of antiangiogenic genes

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12 December 2020

Preclinical and clinical study of HER-2/neu-targeting cancer gene therapy

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12 December 2020

Liposome-mediated DNA vaccination: the effect of vesicle composition

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12 December 2020

Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure

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12 December 2020

Lipid-DNA complexes induce potent activation of innate immune responses and antitumor activity when administered intravenously

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12 December 2020

Immunomodulatory activity of some amphiphilic compounds

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12 December 2020

The Cell Biology of Macrophage Activation

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12 December 2020

Surface densities of diaphragmed fenestrae and transendothelial channels in different murine capillary beds

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12 December 2020

The role of CXC chemokines as regulators of angiogenesis

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12 December 2020

Mosaic blood vessels in tumors: frequency of cancer cells in contact with flowing blood

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12 December 2020

Interleukin 12, interferon gamma, and tumor necrosis factor alpha are the key cytokines of the generalized Shwartzman reaction

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12 December 2020

On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids

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12 December 2020

Factors influencing the efficiency of cationic liposome-mediated intravenous gene delivery

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12 December 2020

Use of dithiodiglycolic acid as a tether for cationic lipids decreases the cytotoxicity and increases transgene expression of plasmid DNA in vitro

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12 December 2020

Phase II study of direct intralesional gene transfer of allovectin-7, an HLA-B7/beta2-microglobulin DNA-liposome complex, in patients with metastatic melanoma

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12 December 2020

Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis

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12 December 2020

Synthesis of novel cationic lipids: effect of structural modification on the efficiency of gene transfer

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12 December 2020

Direct gene delivery to synovium. An evaluation of potential vectors in vitro and in vivo

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12 December 2020

Activation of host antitumoral responses by cationic lipid/DNA complexes.

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12 December 2020

Transfection Mediated by Gemini Surfactants: Engineered Escape from the Endosomal Compartment

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12 December 2020

Biochemical and biophysical characteristics of lipoplexes pertinent to solid tumour gene therapy

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12 December 2020

10.1007/S00109-004-0558-8

Identifiers

DOI

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10 August 2017

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