JNK pathway signaling: a novel and smarter therapeutic targets for various biological diseases. (Q35822826)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26505831%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

title

JNK pathway signaling: a novel and smarter therapeutic targets for various biological diseases (English)

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28 February 2020

3

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28 February 2020

author name string

Ankit Kumar

1

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28 February 2020

Umesh K Singh

2

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28 February 2020

Vikas Garg

4

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28 February 2020

Saurabh Agrawal

5

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28 February 2020

Praveen K Tomar

6

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28 February 2020

Prateek Pathak

7

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28 February 2020

Anurag Chaudhary

8

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28 February 2020

Pratibha Gupta

9

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28 February 2020

Amrita Malik

10

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28 February 2020

publication date

27 October 2015

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Future Medicinal Chemistry

28 February 2020

published in

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28 February 2020

volume

7

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28 February 2020

issue

15

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28 February 2020

page(s)

2065-2086

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Diverse Roles of JNK and MKK Pathways in the Brain

28 February 2020

cites work

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Targeting JNK3 for the treatment of neurodegenerative disorders

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A central role for JNK in obesity and insulin resistance

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Oxidative stress, ER stress, and the JNK pathway in type 2 diabetes

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JNK: a new therapeutic target for diabetes

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Novel roles for JNK1 in metabolism

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cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance

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JNK-1 deficiency limits macrophage-mediated antigen-induced arthritis

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Joint damage and inflammation in c-Jun N-terminal kinase 2 knockout mice with passive murine collagen-induced arthritis

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Asthmatic airway smooth muscle CXCL10 production: mitogen-activated protein kinase JNK involvement.

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Role of JNK in mammary gland development and breast cancer

21 January 2018

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JNK signaling in apoptosis

21 January 2018

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Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation

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JNK3 perpetuates metabolic stress induced by Aβ peptides.

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JNK regulates APP cleavage and degradation in a model of Alzheimer's disease.

21 January 2018

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Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease

21 January 2018

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Levodopa activates apoptosis signaling kinase 1 (ASK1) and promotes apoptosis in a neuronal model: implications for the treatment of Parkinson's disease

21 January 2018

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JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease

21 January 2018

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Targeting the JNK pathway as a therapeutic protective strategy for nervous system diseases

21 January 2018

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JNK signalling: a possible target to prevent neurodegeneration.

21 January 2018

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A Cytoplasmic Inhibitor of the JNK Signal Transduction Pathway

21 January 2018

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21 January 2018

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The scaffold protein IB1/JIP-1 is a critical mediator of cytokine-induced apoptosis in pancreatic beta cells

21 January 2018

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The JNK are important for development and survival of macrophages

21 January 2018

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Islet-brain (IB)/JNK-interacting proteins (JIPs): future targets for the treatment of neurodegenerative diseases?

21 January 2018

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The role of mitogen-activated protein kinase phosphatase-1 in oxidative damage-induced cell death

21 January 2018

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A signaling mechanism from G alpha q-protein-coupled metabotropic glutamate receptors to gene expression: role of the c-Jun N-terminal kinase pathway.

21 January 2018

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c-Src is activated by the epidermal growth factor receptor in a pathway that mediates JNK and ERK activation by gonadotropin-releasing hormone in COS7 cells

21 January 2018

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The ASK1-MAP kinase cascades in mammalian stress response

21 January 2018

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The role of c-Jun N-terminal kinase, p38, and extracellular signal-regulated kinase in insulin-induced Thr69 and Thr71 phosphorylation of activating transcription factor 2.

21 January 2018

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c-Jun controls the efficiency of MAP kinase signaling by transcriptional repression of MAP kinase phosphatases

21 January 2018

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Discovery of Potent and Selective Covalent Inhibitors of JNK

21 January 2018

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Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase.

21 January 2018

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Inhibition of c-Jun N-terminal kinase decreases cardiomyocyte apoptosis and infarct size after myocardial ischemia and reperfusion in anaesthetized rats

21 January 2018

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AS601245 (1,3-benzothiazol-2-yl (2-[[2-(3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile): a c-Jun NH2-terminal protein kinase inhibitor with neuroprotective properties

21 January 2018

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Characterization of immune cell subsets during the active phase of multiple sclerosis reveals disease and c-Jun N-terminal kinase pathway biomarkers.

21 January 2018

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Development of indole/indazole-aminopyrimidines as inhibitors of c-Jun N-terminal kinase (JNK): optimization for JNK potency and physicochemical properties

21 January 2018

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Development of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): kinase profiling guided optimization of a 1,2,3-benzotriazole lead

21 January 2018

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Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies.

21 January 2018

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Synthesis and SAR of aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors

21 January 2018

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Synthesis and SAR of 2-phenoxypyridines as novel c-Jun N-terminal kinase inhibitors

21 January 2018

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Synthesis and SAR of 4-(pyrazol-3-yl)-pyridines as novel c-jun N-terminal kinase inhibitors

21 January 2018

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N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3

21 January 2018

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Design, synthesis, and structure-activity relationship studies of thiophene-3-carboxamide derivatives as dual inhibitors of the c-Jun N-terminal kinase

21 January 2018

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Identification of a new JNK inhibitor targeting the JNK-JIP interaction site

21 January 2018

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Synthesis and optimization of thiadiazole derivatives as a novel class of substrate competitive c-Jun N-terminal kinase inhibitors

21 January 2018

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Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK

21 January 2018

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Highly selective c-Jun N-terminal kinase (JNK) 3 inhibitors with in vitro CNS-like pharmacokinetic properties II. Central core replacement.

21 January 2018

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Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor

21 January 2018

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Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration

21 January 2018

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Structure-Activity Relationships and X-ray Structures Describing the Selectivity of Aminopyrazole Inhibitors for c-Jun N-terminal Kinase 3 (JNK3) over p38

21 January 2018

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Design, synthesis, and structure-activity relationship of substrate competitive, selective, and in vivo active triazole and thiadiazole inhibitors of the c-Jun N-terminal kinase

21 January 2018

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Discovery of 2-(5-nitrothiazol-2-ylthio)benzo[d]thiazoles as novel c-Jun N-terminal kinase inhibitors

21 January 2018

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Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.15.132

Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis.

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.15.132

Aminopurine based JNK inhibitors for the prevention of ischemia reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.15.132

The c-Jun N-terminal kinase inhibitor SP600125 is neuroprotective in amygdala kindled rats

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.15.132

Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.15.132

c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.15.132

Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1)

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.15.132

Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (2)

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.15.132

1-Aryl-3,4-dihydroisoquinoline inhibitors of JNK3

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.15.132

3,5-Disubstituted quinolines as novel c-Jun N-terminal kinase inhibitors

21 January 2018

1 reference

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Synthesis and SAR of novel quinazolines as potent and brain-penetrant c-jun N-terminal kinase (JNK) inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.15.132

Hit-to-lead optimization and kinase selectivity of imidazo[1,2-a]quinoxalin-4-amine derived JNK1 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.15.132

Synthesis and SAR of piperazine amides as novel c-jun N-terminal kinase (JNK) inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.15.132

21 January 2018

Identifiers

DOI

10.4155/FMC.15.132

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release_nl7n6r226bgrhciw2balrvdhb4

28 February 2020

Fatcat ID

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mapped directly with Wikidata item

24 November 2022

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