Mechanical loading-related changes in osteocyte sclerostin expression in mice are more closely associated with the subsequent osteogenic response than the peak strains engendered (Q35831180)

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scientific article published on 15 May 2011

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English	Mechanical loading-related changes in osteocyte sclerostin expression in mice are more closely associated with the subsequent osteogenic response than the peak strains engendered	scientific article published on 15 May 2011

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scholarly article

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Europe PubMed Central

PMC publication ID

10 August 2017

Mechanical loading-related changes in osteocyte sclerostin expression in mice are more closely associated with the subsequent osteogenic response than the peak strains engendered (English)

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Toshihiro Sugiyama

2

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T Sugiyama

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Europe PubMed Central

PMC publication ID

10 August 2017

Jitendra Prasad

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J Prasad

3

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author name string

A Moustafa

1

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Europe PubMed Central

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10 August 2017

G Zaman

4

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Europe PubMed Central

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10 August 2017

T S Gross

5

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Europe PubMed Central

PMC publication ID

10 August 2017

L E Lanyon

6

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10 August 2017

J S Price

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10 August 2017

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publication date

15 May 2011

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10 August 2017

Osteoporosis International

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10 August 2017

23

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10 August 2017

4

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Europe PubMed Central

PMC publication ID

10 August 2017

1225-1234

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Europe PubMed Central

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10 August 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3304063/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Role of endocrine and paracrine factors in the adaptation of bone to mechanical loading

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3304063

11 July 2018

Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3304063

11 July 2018

Mechanical loading-related bone gain is enhanced by tamoxifen but unaffected by fulvestrant in female mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3304063

11 July 2018

Effects of parathyroid hormone treatment on circulating sclerostin levels in postmenopausal women

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3304063

11 July 2018

Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody

1 reference

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11 July 2018

Cancellous bone adaptation to tibial compression is not sex dependent in growing mice

1 reference

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11 July 2018

Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength

1 reference

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11 July 2018

Serum sclerostin levels negatively correlate with parathyroid hormone levels and free estrogen index in postmenopausal women

1 reference

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Loading-related regulation of gene expression in bone in the contexts of estrogen deficiency, lack of estrogen receptor alpha and disuse

1 reference

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The matricellular protein periostin is required for sost inhibition and the anabolic response to mechanical loading and physical activity

1 reference

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11 July 2018

Functional adaptation to mechanical loading in both cortical and cancellous bone is controlled locally and is confined to the loaded bones

1 reference

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Parathyroid hormone (PTH)-induced bone gain is blunted in SOST overexpressing and deficient mice

1 reference

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11 July 2018

The mouse fibula as a suitable bone for the study of functional adaptation to mechanical loading

1 reference

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Pro-inflammatory cytokines TNF-related weak inducer of apoptosis (TWEAK) and TNFalpha induce the mitogen-activated protein kinase (MAPK)-dependent expression of sclerostin in human osteoblasts

1 reference

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11 July 2018

Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin

1 reference

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11 July 2018

Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation

1 reference

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11 July 2018

Measurement of microstructural strain in cortical bone

1 reference

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Osteocyte lacunae tissue strain in cortical bone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3304063

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SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

1 reference

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11 July 2018

Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling

1 reference

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Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist

1 reference

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11 July 2018

Osteocyte control of bone formation via sclerostin, a novel BMP antagonist

1 reference

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11 July 2018

Low-magnitude mechanical loading becomes osteogenic when rest is inserted between each load cycle

1 reference

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11 July 2018

A 52-kb deletion in the SOST-MEOX1 intergenic region on 17q12-q21 is associated with van Buchem disease in the Dutch population

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3304063

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Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease

1 reference

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Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

1 reference

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Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein

1 reference

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Comparing histological, vascular and molecular responses associated with woven and lamellar bone formation induced by mechanical loading in the rat ulna

1 reference

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Sclerostin and the regulation of bone formation: Effects in hip osteoarthritis and femoral neck fracture.

1 reference

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24 September 2018

Androgen receptor disruption increases the osteogenic response to mechanical loading in male mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3304063

24 September 2018

Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3304063

24 September 2018

The anabolic action of intermittent PTH in combination with cathepsin K inhibitor or alendronate differs depending on the remodeling status in bone in ovariectomized mice

1 reference

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24 September 2018

3D strain map of axially loaded mouse tibia: a numerical analysis validated by experimental measurements.

1 reference

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24 September 2018

Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1-34) on trabecular and cortical bone in mice

1 reference

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24 September 2018

Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength

1 reference

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24 September 2018

Non-invasive axial loading of mouse tibiae increases cortical bone formation and modifies trabecular organization: a new model to study cortical and cancellous compartments in a single loaded element.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3304063

24 September 2018

Uniformity of resorptive bone loss induced by disuse

1 reference

https://pubmed.ncbi.nlm.nih.gov/21573880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Strain magnitude related changes in whole bone architecture in growing rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/21573880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Strain gradients correlate with sites of periosteal bone formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21573880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/21573880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

OPG and RANKL mRNA and protein expressions in the primary and secondary metaphyseal trabecular bone of PTH-treated rats are independent of that of SOST

1 reference

https://pubmed.ncbi.nlm.nih.gov/21573880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased sclerostin serum levels associated with bone formation and resorption markers in patients with immobilization-induced bone loss

1 reference

https://pubmed.ncbi.nlm.nih.gov/21573880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetics of osteoporosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21573880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterizing gait induced normal strains in a murine tibia cortical bone defect model

1 reference

https://pubmed.ncbi.nlm.nih.gov/21573880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neutralisation of Dkk-1 protects from systemic bone loss during inflammation and reduces sclerostin expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/21573880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00198-011-1656-4

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

ResearchGate publication ID

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