Lack of evidence for presenilins as endoplasmic reticulum Ca2+ leak channels (Q35879583)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22311977%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

title

Lack of evidence for presenilins as endoplasmic reticulum Ca2+ leak channels (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22311977%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

main subject

endoplasmic reticulum

0 references

author

J. Kevin Foskett

4

1 reference

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22 January 2020

author name string

Dustin Shilling

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22311977%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Don-On Daniel Mak

2

1 reference

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22 January 2020

David E Kang

3

1 reference

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22 January 2020

language of work or name

English

0 references

publication date

6 February 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22311977%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

22 January 2020

published in

1 reference

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22 January 2020

volume

287

1 reference

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22 January 2020

issue

14

1 reference

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22 January 2020

page(s)

10933-10944

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22311977%20AND%20SRC:MED&resulttype=core&format=json

Mutagenesis mapping of the presenilin 1 calcium leak conductance pore

22 January 2020

cites work

1 reference

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Familial Alzheimer's disease mutations in presenilins: effects on endoplasmic reticulum calcium homeostasis and correlation with clinical phenotypes

11 July 2018

1 reference

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Role of presenilins in neuronal calcium homeostasis

11 July 2018

1 reference

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Unique characteristics of Ca2+ homeostasis of the trans-Golgi compartment

11 July 2018

1 reference

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Gain-of-function enhancement of IP3 receptor modal gating by familial Alzheimer's disease-linked presenilin mutants in human cells and mouse neurons

11 July 2018

1 reference

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ER calcium and Alzheimer's disease: in a state of flux

11 July 2018

1 reference

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Masking of transmembrane-based retention signals controls ER export of gamma-secretase

11 July 2018

1 reference

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Calcium hypothesis of Alzheimer's disease

11 July 2018

1 reference

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Presenilin-2 dampens intracellular Ca2+ stores by increasing Ca2+ leakage and reducing Ca2+ uptake

11 July 2018

1 reference

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Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

11 July 2018

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SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production

11 July 2018

1 reference

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Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating.

11 July 2018

1 reference

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Assembly, maturation, and trafficking of the gamma-secretase complex in Alzheimer's disease

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322867

Presenilin 1 regulates epidermal growth factor receptor turnover and signaling in the endosomal-lysosomal pathway.

11 July 2018

1 reference

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Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1

11 July 2018

1 reference

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Measuring calcium signaling using genetically targetable fluorescent indicators

11 July 2018

1 reference

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Calcium and neurodegeneration

11 July 2018

1 reference

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Presenilins and Alzheimer disease: the calcium conspiracy.

11 July 2018

1 reference

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Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322867

Presenilin-1 maintains a nine-transmembrane topology throughout the secretory pathway

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322867

A nine-transmembrane domain topology for presenilin 1

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322867

Reduction of Ca2+ stores and capacitative Ca2+ entry is associated with the familial Alzheimer's disease presenilin-2 T122R mutation and anticipates the onset of dementia.

11 July 2018

1 reference

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Calcium dysregulation, IP3 signaling, and Alzheimer's disease

11 July 2018

1 reference

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Bcl-2-mediated alterations in endoplasmic reticulum Ca2+ analyzed with an improved genetically encoded fluorescent sensor

11 July 2018

1 reference

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The presenilin 2 M239I mutation associated with familial Alzheimer's disease reduces Ca2+ release from intracellular stores

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322867

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

11 July 2018

1 reference

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Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease

11 July 2018

1 reference

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A new generation of Ca2+ indicators with greatly improved fluorescence properties

11 July 2018

1 reference

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Intracellular Ca2+ pools in PC12 cells. Three intracellular pools are distinguished by their turnover and mechanisms of Ca2+ accumulation, storage, and release

11 July 2018

1 reference

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Characterization of ionomycin as a calcium ionophore

11 July 2018

1 reference

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Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

11 July 2018

1 reference

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Alzheimer disease: presenilin springs a leak.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.300491

Alzheimer's disease. Fresh evidence points to an old suspect: calcium.

21 January 2018

1 reference

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Calcium responses in fibroblasts from asymptomatic members of Alzheimer's disease families

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.300491

Calcium responses in human fibroblasts: a diagnostic molecular profile for Alzheimer's disease.

21 January 2018

1 reference

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Deviant ryanodine receptor-mediated calcium release resets synaptic homeostasis in presymptomatic 3xTg-AD mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.300491

Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer's-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.300491

Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.300491

Enhanced ryanodine-mediated calcium release in mutant PS1-expressing Alzheimer's mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.300491

Enhanced caffeine-induced Ca2+ release in the 3xTg-AD mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.300491

Using a genetically targeted sensor to investigate the role of presenilin-1 in ER Ca2+ levels and dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.300491

Presenilin mutations linked to familial Alzheimer's disease reduce endoplasmic reticulum and Golgi apparatus calcium levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.300491

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.300491

Culturing hippocampal and cortical neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.300491

Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.300491

Up-regulation of inositol 1,4,5-trisphosphate receptor type 1 is responsible for a decreased endoplasmic-reticulum Ca2+ content in presenilin double knock-out cells

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22311977

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M111.300491

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22311977%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22311977%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

PubMed publication ID

22311977

1 reference