Checking on DNA damage in S phase (Q35906070)

11 August 2017

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title

Checking on DNA damage in S phase (English)

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11 August 2017

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3

Jiri Lukas

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Jiří Bártek

series ordinal

1

object named as

Jiri Bartek

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Claudia Lukas

object named as

Claudia Lukas

series ordinal

2

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publication date

1 October 2004

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Nature Reviews Molecular Cell Biology

11 August 2017

published in

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11 August 2017

volume

5

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11 August 2017

issue

10

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11 August 2017

page(s)

792-804

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The DNA damage response: putting checkpoints in perspective

11 August 2017

cites work

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Toward maintaining the genome: DNA damage and replication checkpoints

21 January 2018

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Genome maintenance mechanisms for preventing cancer

21 January 2018

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21 January 2018

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Cell cycle checkpoint signaling through the ATM and ATR kinases

21 January 2018

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Pathways governing G1/S transition and their response to DNA damage

21 January 2018

1 reference

Differentiation-induced radioresistance in muscle cells

21 January 2018

1 reference

Suppression of spontaneous chromosomal rearrangements by S phase checkpoint functions in Saccharomyces cerevisiae

21 January 2018

1 reference

Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae

21 January 2018

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Molecular views of recombination proteins and their control

21 January 2018

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Visualization of altered replication dynamics after DNA damage in human cells

21 January 2018

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Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage

21 January 2018

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The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways

21 January 2018

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ATM: genome stability, neuronal development, and cancer cross paths

21 January 2018

2 references

21 January 2018

inferred from DOI database lookup

7 January 2021

based on heuristic

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

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Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

21 January 2018

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Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage

21 January 2018

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Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation

21 January 2018

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The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

21 January 2018

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Requirement of the MRN complex for ATM activation by DNA damage

21 January 2018

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The Mre11 complex is required for ATM activation and the G2/M checkpoint

21 January 2018

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Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation

21 January 2018

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Mre11 assembles linear DNA fragments into DNA damage signaling complexes

21 January 2018

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Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

21 January 2018

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Checkpoint activation in response to double-strand breaks requires the Mre11/Rad50/Xrs2 complex

21 January 2018

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21 January 2018

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Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin

21 January 2018

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Checking on the fork: the DNA-replication stress-response pathway

21 January 2018

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Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

21 January 2018

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ATR and ATRIP: partners in checkpoint signaling

21 January 2018

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ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage

21 January 2018

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ATR and ATM regulate the timing of DNA replication origin firing

21 January 2018

1 reference

Control of replication origin density and firing time in Xenopus egg extracts: role of a caffeine-sensitive, ATR-dependent checkpoint.

21 January 2018

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Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

21 January 2018

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Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems

21 January 2018

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MDC1 is required for the intra-S-phase DNA damage checkpoint

21 January 2018

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MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

21 January 2018

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MDC1 is a mediator of the mammalian DNA damage checkpoint

21 January 2018

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NFBD1/KIAA0170 is a novel nuclear transcriptional transactivator with BRCT domain

21 January 2018

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NFBD1, a novel nuclear protein with signature motifs of FHA and BRCT, and an internal 41-amino acid repeat sequence, is an early participant in DNA damage response

21 January 2018

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NFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways

21 January 2018

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53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

21 January 2018

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p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice

21 January 2018

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53BP1, a mediator of the DNA damage checkpoint

21 January 2018

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Cancer susceptibility and the functions of BRCA1 and BRCA2

21 January 2018

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Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway

21 January 2018

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Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation

21 January 2018

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Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts

21 January 2018

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Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17.

21 January 2018

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Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

21 January 2018

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Interfaces between the detection, signaling, and repair of DNA damage

21 January 2018

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Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control

21 January 2018

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Nibrin forkhead-associated domain and breast cancer C-terminal domain are both required for nuclear focus formation and phosphorylation

21 January 2018

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Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization

21 January 2018

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BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

21 January 2018

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The BRCT Domain Is a Phospho-Protein Binding Domain

21 January 2018

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Action of DNA repair endonuclease ERCC1/XPF in living cells

21 January 2018

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Xeroderma pigmentosum group A protein loads as a separate factor onto DNA lesions

21 January 2018

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DNA damage stabilizes interaction of CSB with the transcription elongation machinery

21 January 2018

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Nuclear dynamics of RAD52 group homologous recombination proteins in response to DNA damage.

21 January 2018

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Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage

21 January 2018

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SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint

21 January 2018

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Megabase chromatin domains involved in DNA double-strand breaks in vivo

21 January 2018

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Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

21 January 2018

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Chk1 and Chk2 kinases in checkpoint control and cancer

21 January 2018

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Regulating mammalian checkpoints through Cdc25 inactivation

21 January 2018

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Rapid destruction of human Cdc25A in response to DNA damage

21 January 2018

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Human Cdc25 A inactivation in response to S phase inhibition and its role in preventing premature mitosis

21 January 2018

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The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

21 January 2018

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Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability

21 January 2018

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Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

21 January 2018

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Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints

21 January 2018

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Dual mode of degradation of Cdc25 A phosphatase

21 January 2018

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F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex

21 January 2018

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The F-box protein family.

21 January 2018

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The SCF ubiquitin ligase: an extended look

21 January 2018

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Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage

21 January 2018

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SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase

21 January 2018

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Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner

21 January 2018

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Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

21 January 2018

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Interaction of FANCD2 and NBS1 in the DNA damage response

21 January 2018

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BCR/ABL translocates to the nucleus and disrupts an ATR-dependent intra-S phase checkpoint

21 January 2018

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The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways

21 January 2018

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Phosphorylation of histone H2B at DNA double-strand breaks.

21 January 2018

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Replicon clusters are stable units of chromosome structure: evidence that nuclear organization contributes to the efficient activation and propagation of S phase in human cells

21 January 2018

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Spatial and temporal dynamics of DNA replication sites in mammalian cells

21 January 2018

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The many functions of SMC proteins in chromosome dynamics

21 January 2018

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DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1

21 January 2018

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Targeting the checkpoint kinases: chemosensitization versus chemoprotection

21 January 2018

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A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome

21 January 2018

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Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint

21 January 2018

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Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1

21 January 2018

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An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication

21 January 2018

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The Cdc7/Dbf4 protein kinase: target of the S phase checkpoint?

21 January 2018

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Temporally coordinated assembly and disassembly of replication factories in the absence of DNA synthesis

21 January 2018

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The DNA replication checkpoint response stabilizes stalled replication forks

21 January 2018

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Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint

21 January 2018

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ORC and the intra-S-phase checkpoint: a threshold regulates Rad53p activation in S phase

21 January 2018

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Suppression of genome instability by redundant S-phase checkpoint pathways in Saccharomyces cerevisiae

21 January 2018

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Regulation of human Cdc25A stability by Serine 75 phosphorylation is not sufficient to activate a S phase checkpoint

21 January 2018

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Phosphorylation at serine 75 is required for UV-mediated degradation of human Cdc25A phosphatase at the S-phase checkpoint

21 January 2018

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Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: Evidence for multiple roles of mitotic cyclins

21 January 2018

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The mismatch repair system is required for S-phase checkpoint activation

21 January 2018

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Is mismatch repair really required for ionizing radiation-induced DNA damage signaling?

21 January 2018

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Checkpoints: controls that ensure the order of cell cycle events

21 January 2018

1 reference

Radiosensitivity in ataxia-telangiectasia: a new explanation

31 March 2020

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The cellular response to DNA double-strand breaks: defining the sensors and mediators

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRM1493

1 reference

11 August 2017

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