GQ5 Hinders Renal Fibrosis in Obstructive Nephropathy by Selectively Inhibiting TGF-β-Induced Smad3 Phosphorylation (Q35903089)

https://doi.org/10.1681/ASN.0000000000000307

11 August 2017

1 reference

14 April 2024

title

GQ5 Hinders Renal Fibrosis in Obstructive Nephropathy by Selectively Inhibiting TGF-β-Induced Smad3 Phosphorylation (English)

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11 August 2017

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obstructive nephropathy

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1 reference

Jun Ai

1

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11 August 2017

Jing Nie

2

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11 August 2017

Jiangbo He

3

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11 August 2017

Qin Guo

4

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11 August 2017

Mei Li

5

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11 August 2017

Ying Lei

6

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11 August 2017

Youhua Liu

7

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11 August 2017

Zhanmei Zhou

8

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11 August 2017

Fengxin Zhu

9

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11 August 2017

Min Liang

10

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11 August 2017

Yongxian Cheng

11

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11 August 2017

Fan Fan Hou

12

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11 August 2017

12 November 2014

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Journal of the American Society of Nephrology

11 August 2017

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11 August 2017

26

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11 August 2017

8

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11 August 2017

1827-1838

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Kindlin-2 mediates activation of TGF-β/Smad signaling and renal fibrosis

11 August 2017

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Renal fibrosis: novel insights into mechanisms and therapeutic targets.

27 July 2018

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Blockade of endothelial-mesenchymal transition by a Smad3 inhibitor delays the early development of streptozotocin-induced diabetic nephropathy

27 July 2018

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tPA is a potent mitogen for renal interstitial fibroblasts: role of beta1 integrin/focal adhesion kinase signaling

27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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IN-1130, a novel transforming growth factor-beta type I receptor kinase (ALK5) inhibitor, suppresses renal fibrosis in obstructive nephropathy

27 July 2018

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27 July 2018

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27 July 2018

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TGF-beta signaling and the fibrotic response

27 July 2018

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27 July 2018

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Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction

27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects

27 July 2018

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SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

27 July 2018

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Smad7 inhibits fibrotic effect of TGF-Beta on renal tubular epithelial cells by blocking Smad2 activation

27 July 2018

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Smad3/AP-1 interactions control transcriptional responses to TGF-beta in a promoter-specific manner

27 July 2018

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SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor

27 July 2018

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SMAD3/4-dependent transcriptional activation of the human type VII collagen gene (COL7A1) promoter by transforming growth factor beta.

27 July 2018

1 reference

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TGF-beta signal transduction

27 July 2018

1 reference

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Chimeric extracellular domain type II transforming growth factor (TGF)-beta receptor fused to the Fc region of human immunoglobulin as a TGF-beta antagonist

27 July 2018

1 reference

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Transforming growth factor-beta receptor types I and II are expressed in renal tubules and are increased after chronic unilateral ureteral obstruction

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4520163

TGF-beta signalling from cell membrane to nucleus through SMAD proteins

27 July 2018

1 reference

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Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.

27 July 2018

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Negative regulation of transforming growth factor-beta by the proteoglycan decorin

27 July 2018

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Five subtypes of type A gamma-aminobutyric acid receptors identified in neurons by double and triple immunofluorescence staining with subunit-specific antibodies

27 July 2018

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Divergent roles of Smad3 and PI3-kinase in murine adriamycin nephropathy indicate distinct mechanisms of proteinuria and fibrogenesis.

27 July 2018

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Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis.

24 September 2018

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Delayed blockade of the kinin B1 receptor reduces renal inflammation and fibrosis in obstructive nephropathy

24 September 2018

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24 September 2018

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Selective inhibition of activin receptor-like kinase 5 signaling blocks profibrotic transforming growth factor beta responses in skin fibroblasts

24 September 2018

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Smad3 deficiency attenuates renal fibrosis, inflammation,and apoptosis after unilateral ureteral obstruction

24 September 2018

1 reference

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The Phosphatidylinositol 3-Kinase/Akt Pathway Enhances Smad3-stimulated Mesangial Cell Collagen I Expression in Response to Transforming Growth Factor-β1

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24 September 2018

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24 September 2018

1 reference

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24 September 2018

1 reference

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24 September 2018

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24 September 2018

1 reference

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Mechanisms of tubulointerstitial fibrosis

24 September 2018

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12 December 2020

It's a Smad world: regulation of TGF-beta signaling in the kidney

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12 December 2020

Stimulation of Type I Collagen Transcription in Human Skin Fibroblasts by TGF-β: Involvement of Smad 3

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12 December 2020

Delayed administration of hepatocyte growth factor reduces renal fibrosis in obstructive nephropathy

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12 December 2020

Increased expression of TGF-beta 1 mRNA in the obstructed kidney of rats with unilateral ureteral ligation

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12 December 2020

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Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-beta1-induced extracellular matrix expression

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12 December 2020

Identifiers

DOI

10.1681/ASN.2014040363

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11 August 2017

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11 August 2017

PubMed publication ID

25392233

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