Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers. (Q35910406)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26831078%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

title

Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers (English)

1 reference

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Correction for Mullarky et al., Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers

6 March 2020

corrigendum / erratum

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author

Lewis C. Cantley

18

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6 March 2020

Reza Beheshti Zavareh

3

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6 March 2020

Pradeep K Singh

10

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6 March 2020

J David Warren

12

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6 March 2020

Sarah-maria Fendt

13

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6 March 2020

Gina M DeNicola

15

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6 March 2020

Costas A Lyssiotis

16

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6 March 2020

Luke L. Lairson

17

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6 March 2020

11

John Blenis

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6 March 2020

author name string

Edouard Mullarky

1

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6 March 2020

Natasha C Lucki

2

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6 March 2020

Justin L Anglin

4

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6 March 2020

Ana P Gomes

5

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6 March 2020

Brandon N Nicolay

6

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6 March 2020

Jenny C Y Wong

7

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6 March 2020

Stefan Christen

8

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6 March 2020

Hidenori Takahashi

9

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6 March 2020

John M Asara

14

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6 March 2020

language of work or name

English

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publication date

1 February 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26831078%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

6 March 2020

number of pages

6

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based on heuristic

inferred from page(s)

published in

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6 March 2020

volume

113

1 reference

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6 March 2020

issue

7

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6 March 2020

page(s)

1778-1783

1 reference

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NRF2 regulates serine biosynthesis in non-small cell lung cancer

6 March 2020

cites work

1 reference

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11 July 2018

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11 July 2018

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Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

11 July 2018

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11 July 2018

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Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth

11 July 2018

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Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

11 July 2018

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Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

11 July 2018

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11 July 2018

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Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

11 July 2018

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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

11 July 2018

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PHGDH amplification and altered glucose metabolism in human melanoma

11 July 2018

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Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

11 July 2018

1 reference

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Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

11 July 2018

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Triple-Negative Breast Cancer

11 July 2018

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Compartmentalization of Mammalian folate-mediated one-carbon metabolism

11 July 2018

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Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis

11 July 2018

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Targeting metabolic transformation for cancer therapy.

11 July 2018

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The landscape of somatic copy-number alteration across human cancers

11 July 2018

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

11 July 2018

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An integrated genomic analysis of human glioblastoma multiforme

11 July 2018

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11 July 2018

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Mitochondrial tumour suppressors: a genetic and biochemical update

11 July 2018

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The ins and outs of sphingolipid synthesis

11 July 2018

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L-serine in disease and development

11 July 2018

1 reference

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

11 July 2018

1 reference

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Molecular biology of mammalian plasma membrane amino acid transporters

11 July 2018

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Control of phosphatidylserine biosynthesis through phosphatidylserine-mediated inhibition of phosphatidylserine synthase I in Chinese hamster ovary cells

11 July 2018

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Human aldehyde dehydrogenase: mechanism of inhibition of disulfiram

11 July 2018

1 reference

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Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma

11 July 2018

1 reference

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The modulation of serine metabolism in hepatoma 3924A during different phases of cellular proliferation in culture

11 July 2018

1 reference

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Serine hydroxymethyltransferase catalyzes the hydrolysis of 5,10-methenyltetrahydrofolate to 5-formyltetrahydrofolate

11 July 2018

1 reference

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The identification of neutral amino acid transport systems

11 July 2018

1 reference

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Determination of confidence intervals of metabolic fluxes estimated from stable isotope measurements

11 July 2018

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24 September 2018

Identifiers

DOI

10.1073/PNAS.1521548113

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26831078%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

0 references

1 reference

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6 March 2020

PubMed publication ID

26831078

1 reference