A unifying model for mTORC1-mediated regulation of mRNA translation. (Q35945036)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22552098%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

title

A unifying model for mTORC1-mediated regulation of mRNA translation (English)

1 reference

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31 January 2020

4

1 reference

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31 January 2020

David M. Sabatini

6

1 reference

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31 January 2020

5

Nathanael S Gray

1 reference

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31 January 2020

author name string

Carson C Thoreen

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22552098%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Lynne Chantranupong

2

1 reference

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31 January 2020

Heather R Keys

3

1 reference

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31 January 2020

language of work or name

English

0 references

publication date

2 May 2012

1 reference

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31 January 2020

1 reference

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31 January 2020

volume

485

1 reference

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31 January 2020

issue

7396

1 reference

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31 January 2020

page(s)

109-113

1 reference

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mTOR: from growth signal integration to cancer, diabetes and ageing

31 January 2020

cites work

1 reference

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Aligning short sequencing reads with Bowtie

2 October 2017

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Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer

2 October 2017

1 reference

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Mammalian microRNAs predominantly act to decrease target mRNA levels

2 October 2017

1 reference

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mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs

2 October 2017

1 reference

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Epithelial-mesenchymal transitions in development and disease

2 October 2017

1 reference

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IRESite--a tool for the examination of viral and cellular internal ribosome entry sites

2 October 2017

1 reference

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DBTSS provides a tissue specific dynamic view of Transcription Start Sites

2 October 2017

1 reference

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Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347774

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

2 October 2017

1 reference

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An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347774

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347774

The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347774

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

2 October 2017

1 reference

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Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347774

Mapping and quantifying mammalian transcriptomes by RNA-Seq

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347774

eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347774

Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347774

Tuberous sclerosis complex proteins 1 and 2 control serum-dependent translation in a TOP-dependent and -independent manner

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347774

p97/DAP5 is a ribosome-associated factor that facilitates protein synthesis and cell proliferation by modulating the synthesis of cell cycle proteins

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347774

A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347774

A second look at cellular mRNA sequences said to function as internal ribosome entry sites

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347774

DINAMelt web server for nucleic acid melting prediction

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347774

Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347774

Cyclin D1 and c-myc internal ribosome entry site (IRES)-dependent translation is regulated by AKT activity and enhanced by rapamycin through a p38 MAPK- and ERK-dependent pathway.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347774

Upstream and downstream of mTOR

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347774

eIF-4E expression and its role in malignancies and metastases.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347774

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347774

AKT activity determines sensitivity to mammalian target of rapamycin (mTOR) inhibitors by regulating cyclin D1 and c-myc expression

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347774

CONTACT INHIBITION, MACROMOLECULAR SYNTHESIS, AND POLYRIBOSOMES IN CULTURED HUMAN DIPLOID FIBROBLASTS

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347774

Global and specific translational control by rapamycin in T cells uncovered by microarrays and proteomics

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347774

Synthesis of the translational apparatus is regulated at the translational level

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347774

Cooperative modulation by eIF4G of eIF4E-binding to the mRNA 5' cap in yeast involves a site partially shared by p20.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347774

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347774

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347774

Identification of the long ubiquitin extension as ribosomal protein S27a

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347774

All translation elongation factors and the e, f, and h subunits of translation initiation factor 3 are encoded by 5'-terminal oligopyrimidine (TOP) mRNAs

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347774

Cap-assisted internal initiation of translation of histone H4

11 July 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22552098

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE11083

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NATURE11083

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22552098%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

31 January 2020

0 references

1 reference

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31 January 2020

PubMed publication ID

22552098

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22552098%20AND%20SRC:MED&resulttype=core&format=json