The β-globin locus control region in combination with the EF1α short promoter allows enhanced lentiviral vector-mediated erythroid gene expression with conserved multilineage activity (Q36054608)

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English	The β-globin locus control region in combination with the EF1α short promoter allows enhanced lentiviral vector-mediated erythroid gene expression with conserved multilineage activity	scientific article

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scholarly article

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Europe PubMed Central

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11 August 2017

The β-globin locus control region in combination with the EF1α short promoter allows enhanced lentiviral vector-mediated erythroid gene expression with conserved multilineage activity (English)

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Europe PubMed Central

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11 August 2017

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Sean Knight

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Mary Collins

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Manfred Schmidt

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Manfred Schmidt

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Lynette Fairbanks

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Lynette Fairbanks

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11 August 2017

Adrian Thrasher

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Adrian J Thrasher

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author name string

Claudia A Montiel-Equihua

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11 August 2017

Lin Zhang

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11 August 2017

Heba Saadeh

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Simone Scholz

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Marlene Carmo

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Maria E Alonso-Ferrero

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Michael P Blundell

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Aiste Monkeviciute

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Yasuhiro Takeuchi

12

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Michael Antoniou

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H Bobby Gaspar

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publication date

20 March 2012

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Molecular Therapy

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11 August 2017

20

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11 August 2017

1400-1409

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Europe PubMed Central

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11 August 2017

A ubiquitous chromatin opening element (UCOE) confers resistance to DNA methylation-mediated silencing of lentiviral vectors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381857

2 October 2017

Effect of the internal promoter on insertional gene activation by lentiviral vectors with an intact HIV long terminal repeat

1 reference

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2 October 2017

Supplying clotting factors from hematopoietic stem cell-derived erythroid and megakaryocytic lineage cells

1 reference

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2 October 2017

Genotoxic potential of lineage-specific lentivirus vectors carrying the beta-globin locus control region

1 reference

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2 October 2017

Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors

1 reference

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2 October 2017

Insertional gene activation by lentiviral and gammaretroviral vectors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381857

2 October 2017

In vivo selection of genetically modified erythroblastic progenitors leads to long-term correction of beta-thalassemia

1 reference

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2 October 2017

Current status of globin gene therapy for the treatment of beta-thalassaemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381857

2 October 2017

Transcription and chromatin organization of a housekeeping gene cluster containing an integrated beta-globin locus control region

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381857

2 October 2017

Physiological promoters reduce the genotoxic risk of integrating gene vectors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381857

2 October 2017

Beta-globin regulation and long-range interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381857

2 October 2017

Self-inactivating gammaretroviral vectors for gene therapy of X-linked severe combined immunodeficiency.

1 reference

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2 October 2017

Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo

1 reference

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2 October 2017

Successful reconstitution of immunity in ADA-SCID by stem cell gene therapy following cessation of PEG-ADA and use of mild preconditioning

1 reference

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2 October 2017

Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381857

2 October 2017

Ex vivo generation of fully mature human red blood cells from hematopoietic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381857

2 October 2017

The human beta-globin locus control region

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381857

2 October 2017

Therapeutic haemoglobin synthesis in beta-thalassaemic mice expressing lentivirus-encoded human beta-globin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381857

2 October 2017

K562--a human leukemia cell line with erythroid features.

1 reference

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2 October 2017

Definition of the minimal requirements within the human beta-globin gene and the dominant control region for high level expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381857

2 October 2017

Activation of the beta-globin locus control region precedes commitment to the erythroid lineage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381857

2 October 2017

Induction of Erythroid-Specific Expression in Murine Erythroleukemia (MEL) Cell Lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381857

11 July 2018

Genome-wide high-throughput integrome analyses by nrLAM-PCR and next-generation sequencing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381857

11 July 2018

Transient proteasome inhibition as a strategy to enhance lentiviral transduction of hematopoietic CD34(+) cells and T lymphocytes: implications for the use of low viral doses and large-size vectors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381857

23 September 2018

Correction of B-cell development in Btk-deficient mice using lentiviral vectors with codon-optimized human BTK.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381857

23 September 2018

Clonal dominance of hematopoietic stem cells triggered by retroviral gene marking.

1 reference

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23 September 2018

Continuous high-titer HIV-1 vector production.

1 reference

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23 September 2018

High-level transduction and gene expression in hematopoietic repopulating cells using a human immunodeficiency [correction of imunodeficiency] virus type 1-based lentiviral vector containing an internal spleen focus forming virus promoter

1 reference

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The 5'HS4 core element of the human beta-globin locus control region is required for high-level globin gene expression in definitive but not in primitive erythropoiesis

1 reference

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Characterization of the regulatory elements in the promoter of the human elongation factor-1 alpha gene.

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Context Dependence of Different Modules for Posttranscriptional Enhancement of Gene Expression from Retroviral Vectors

1 reference

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5 December 2018

Globin Lentiviral Vector Insertions Can Perturb the Expression of Endogenous Genes in β-thalassemic Hematopoietic Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22434141

12 December 2020

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Equal potency of gammaretroviral and lentiviral SIN vectors for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22434141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-globin dominant control region interacts differently with distal and proximal promoter elements

1 reference

https://pubmed.ncbi.nlm.nih.gov/22434141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Successful treatment of murine beta-thalassemia intermedia by transfer of the human beta-globin gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/22434141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human embryonic stem cell-derived CD34+ cells: efficient production in the coculture with OP9 stromal cells and analysis of lymphohematopoietic potential

1 reference

https://pubmed.ncbi.nlm.nih.gov/22434141

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based on heuristic

inferred from PubMed ID database lookup

The beta-globin dominant control region activates homologous and heterologous promoters in a tissue-specific manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/22434141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/MT.2012.50

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

ResearchGate publication ID

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