Osteoarthritis - an untreatable disease? (Q36085680)

12 August 2017

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title

Osteoarthritis - an untreatable disease? (English)

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12 August 2017

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Heike A Wieland

1

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12 August 2017

Martin Michaelis

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2

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12 August 2017

Bernhard J Kirschbaum

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3

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12 August 2017

Karl A Rudolphi

series ordinal

4

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12 August 2017

publication date

1 April 2005

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Nature Reviews Drug Discovery

12 August 2017

published in

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12 August 2017

volume

4

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12 August 2017

issue

4

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12 August 2017

page(s)

331-344

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The bone and joint decade: a catalyst for progress

12 August 2017

cites work

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International variation in hip replacement rates

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Osteoarthritis: symptoms, signs and source of pain

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The development of COX2 inhibitors

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Failing the public health--rofecoxib, Merck, and the FDA.

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Characteristics of COX2 inhibitors questioned

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An update on the pathogenesis and epidemiology of osteoarthritis

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Risk factors for osteoarthritis: genetics

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Structure-modifying agents for osteoarthritis: an update

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EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT)

31 March 2020

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Does paracetamol (acetaminophen) reduce the pain of osteoarthritis? A meta-analysis of randomised controlled trials.

31 March 2020

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A historic issue of the Annals: three papers examine paracetamol in osteoarthritis

31 March 2020

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A comparison of the efficacy and safety of nonsteroidal antiinflammatory agents versus acetaminophen in the treatment of osteoarthritis: a meta-analysis

31 March 2020

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31 March 2020

Cyclooxygenases 1 and 2

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Interleukin-1beta-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity

31 March 2020

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Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis

31 March 2020

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Treatment of osteoarthritis with celecoxib, a cyclooxygenase-2 inhibitor: a randomized controlled trial

31 March 2020

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A randomized trial of the efficacy and tolerability of the COX-2 inhibitor rofecoxib vs ibuprofen in patients with osteoarthritis. Rofecoxib/Ibuprofen Comparator Study Group

31 March 2020

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Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis

31 March 2020

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The use of glucosamine therapy in osteoarthritis

31 March 2020

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Glucosamine for osteoarthritis: magic, hype, or confusion? It's probably safe-but there's no good evidence that it works

31 March 2020

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Efficacy of topical non-steroidal anti-inflammatory drugs in the treatment of osteoarthritis: meta-analysis of randomised controlled trials

31 March 2020

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Topical NSAIDs for chronic musculoskeletal pain: systematic review and meta-analysis

31 March 2020

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Injections in the treatment of osteoarthritis

31 March 2020

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Intra-articular treatments in osteoarthritis: from the symptomatic to the structure modifying

31 March 2020

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Intra-articular corticosteroid treatment in osteoarthritis

31 March 2020

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Intra-articular hyaluronan injections in the treatment of osteoarthritis of the knee: a randomised, double blind, placebo controlled multicentre trial. Hyaluronan Multicentre Trial Group

31 March 2020

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Intraarticular injection of hyaluronan as treatment for knee osteoarthritis: what is the evidence?

31 March 2020

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Intra-articular hyaluronic acid in treatment of knee osteoarthritis: a meta-analysis

31 March 2020

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Signaling transduction: target in osteoarthritis

31 March 2020

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Chemokines in joint disease: the key to inflammation?

31 March 2020

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Functional genomics of osteoarthritis

31 March 2020

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Articular cartilage and changes in arthritis. An introduction: cell biology of osteoarthritis

31 March 2020

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The role of bone in the treatment of osteoarthritis

31 March 2020

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Evidence for a key role of leptin in osteoarthritis

31 March 2020

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Human articular chondrocytes express functional leptin receptors

31 March 2020

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The release of crosslinked peptides from type II collagen into human synovial fluid is increased soon after joint injury and in osteoarthritis

31 March 2020

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Pralnacasan, an inhibitor of interleukin-1beta converting enzyme, reduces joint damage in two murine models of osteoarthritis

31 March 2020

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Suppression of early experimental osteoarthritis by gene transfer of interleukin-1 receptor antagonist and interleukin-10.

31 March 2020

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Differential induction and regulation of matrix metalloproteinases in osteoarthritic tissue and fluid synovial fibroblasts

31 March 2020

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Expression profiling of metalloproteinases and their inhibitors in cartilage

31 March 2020

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Peroxisome proliferator-activated receptor-gamma down-regulates chondrocyte matrix metalloproteinase-1 via a novel composite element

31 March 2020

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Evidence for the presence of peroxisome proliferator-activated receptor (PPAR) alpha and gamma and retinoid Z receptor in cartilage. PPARgamma activation modulates the effects of interleukin-1beta on rat chondrocytes

31 March 2020

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Cyclooxygenase-2 and prostaglandins in articular tissues

31 March 2020

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15d-PGJ(2) is acting as a 'dual agent' on the regulation of COX-2 expression in human osteoarthritic chondrocytes

31 March 2020

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Expression and regulation of inducible IkappaB kinase (IKK-i) in human fibroblast-like synoviocytes

31 March 2020

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Specific Inhibition of IkappaB kinase reduces hyperalgesia in inflammatory and neuropathic pain models in rats.

31 March 2020

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Specific NF-kappaB blockade selectively inhibits tumour necrosis factor-alpha-induced COX-2 but not constitutive COX-1 gene expression in HT-29 cells

31 March 2020

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Subchondral bone changes in hand and knee osteoarthritis detected by radiography

31 March 2020

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Osteoarthritis: Is it a disease of cartilage or of bone?

31 March 2020

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Subchondral bone in osteoarthritis

31 March 2020

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The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model

31 March 2020

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Antiresorptive therapy conserves some periarticular bone and ligament mechanical properties after anterior cruciate ligament disruption in the rabbit knee

31 March 2020

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Are osteophytes good or bad?

31 March 2020

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Growth factor expression in the osteophytes of the human femoral head in osteoarthritis

31 March 2020

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Osteophytes in osteoarthritis. Clinical aspects

31 March 2020

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The relation between cartilage damage and osteophyte size in a murine model for osteoarthritis in the knee

31 March 2020

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Radiographic assessment of symptomatic knee osteoarthritis in the community: definitions and normal joint space

31 March 2020

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Vascular mechanisms in osteoarthritis

31 March 2020

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Leptin regulates bone formation via the sympathetic nervous system

31 March 2020

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Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass

31 March 2020

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31 March 2020

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MAST CELLS IN THE SYNOVIUM AND SYNOVIAL FLUID IN OSTEOARTHRHIS

31 March 2020

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Arthroscopic and immunohistologic characterization of knee joint synovitis in osteoarthritis

31 March 2020

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Calcium crystal-induced inflammation

31 March 2020

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Neoantigens in osteoarthritic cartilage

31 March 2020

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Biochemical/immunochemical biomarkers of osteoarthritis: utility for prediction of incident or progressive osteoarthritis

31 March 2020

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Innervation of the synovium

31 March 2020

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Involvement of the proinflammatory cytokines tumor necrosis factor-alpha, IL-1 beta, and IL-6 but not IL-8 in the development of heat hyperalgesia: effects on heat-evoked calcitonin gene-related peptide release from rat skin.

31 March 2020

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Contribution of interleukin‐1β to the inflammation‐induced increase in nerve growth factor levels and inflammatory hyperalgesia

31 March 2020

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Cytokines, nerve growth factor and inflammatory hyperalgesia: the contribution of tumour necrosis factor alpha

31 March 2020

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Mechanical sensitization of cutaneous C-fiber nociceptors by prostaglandin E2 in the rat.

31 March 2020

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Pain and hyperalgesia after intradermal injection of bradykinin in humans

31 March 2020

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Distribution of neuropeptides in synovium of the knee with osteoarthritis

31 March 2020

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Sensorimotor changes and functional performance in patients with knee osteoarthritis.

31 March 2020

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Exercise for knee osteoarthritis

31 March 2020

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Quadriceps Weakness and Osteoarthritis of the Knee

31 March 2020

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Neuromuscular quadriceps dysfunction prior to osteoarthritis of the knee

31 March 2020

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Quadriceps strength and osteoarthritis progression in malaligned and lax knees

31 March 2020

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Mechanisms of pain in arthritis

31 March 2020

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Mechanisms of inflammatory pain

31 March 2020

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Systems biology in drug discovery

31 March 2020

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Osteoarthritis, angiogenesis and inflammation

31 March 2020

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Angiogenesis in osteoarthritis and spondylosis: successful repair with undesirable outcomes.

31 March 2020

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Hereditary disorders mimicking and/or causing premature osteoarthritis

31 March 2020

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Inverse relationship osteoarthritis-osteoporosis: what is the evidence? What are the consequences?

31 March 2020

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Osteoarthritis as a systemic disorder including stromal cell differentiation and lipid metabolism

31 March 2020

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Bone and fat: old questions, new insights

31 March 2020

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Systemic and local regulation of articular cartilage metabolism: Where does leptin fit in the puzzle?

31 March 2020

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A human chondrogenic cell line retains multi-potency that differentiates into osteoblasts and adipocytes

31 March 2020

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The design, structure, and clinical update of small molecular weight matrix metalloproteinase inhibitors

31 March 2020

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Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), reduction in ulcer complications: randomised controlled trial

31 March 2020

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Safety of anti-inflammatory treatment--new ways of thinking

31 March 2020

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The therapeutic potential of NO-NSAIDs

31 March 2020

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Cyclooxygenase and nitric oxide systems in the gut as therapeutic targets for safer anti-inflammatory drugs

31 March 2020

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Uncoupling of type II collagen synthesis and degradation predicts progression of joint damage in patients with knee osteoarthritis

31 March 2020

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The influence of alignment on risk of knee osteoarthritis progression according to baseline stage of disease

31 March 2020

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Suggestion of nonlinear or phasic progression of knee osteoarthritis based on measurements of serum cartilage oligomeric matrix protein levels over five years

31 March 2020

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Can the pharmaceutical industry reduce attrition rates?

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRD1693

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Dimensions Publication ID

12 August 2017

1013230240

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