Inferring synthetic lethal interactions from mutual exclusivity of genetic events in cancer. (Q36111892)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26427375%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

title

Inferring synthetic lethal interactions from mutual exclusivity of genetic events in cancer (English)

1 reference

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25 February 2020

1 reference

1

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25 February 2020

Jitin Singla

2

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25 February 2020

Limsoon Wong

3

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25 February 2020

Mark A. Ragan

4

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25 February 2020

author name string

Sriganesh Srihari

1

1 reference

12 August 2017

Jitin Singla

2

1 reference

12 August 2017

Limsoon Wong

3

1 reference

12 August 2017

Mark A Ragan

4

1 reference

12 August 2017

1 October 2015

1 reference

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25 February 2020

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25 February 2020

volume

10

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25 February 2020

page(s)

57

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Targeted Therapies for Triple-Negative Breast Cancer: Combating a Stubborn Disease

25 February 2020

cites work

1 reference

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CoMEt: a statistical approach to identify combinations of mutually exclusive alterations in cancer

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Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma

2 October 2017

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Intra-tumor genetic heterogeneity and alternative driver genetic alterations in breast cancers with heterogeneous HER2 gene amplification

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Predicting essential genes and synthetic lethality via influence propagation in signaling pathways of cancer cell fates

2 October 2017

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Therapeutic targeting of tumor suppressor genes

2 October 2017

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Applying synthetic lethality for the selective targeting of cancer.

2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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Online survival analysis software to assess the prognostic value of biomarkers using transcriptomic data in non-small-cell lung cancer

2 October 2017

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Synthetic lethality between CCNE1 amplification and loss of BRCA1.

2 October 2017

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A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities

2 October 2017

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2 October 2017

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A comparative genomic approach for identifying synthetic lethal interactions in human cancer

2 October 2017

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DNA double-strand break repair as determinant of cellular radiosensitivity to killing and target in radiation therapy

2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

Cancer genome landscapes

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Saccharomyces cerevisiae genetics predicts candidate therapeutic genetic interactions at the mammalian replication fork

2 October 2017

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Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review

2 October 2017

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An evolutionarily conserved synthetic lethal interaction network identifies FEN1 as a broad-spectrum target for anticancer therapeutic development

2 October 2017

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2 October 2017

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Comprehensive molecular portraits of human breast tumours

2 October 2017

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Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies

2 October 2017

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The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data

2 October 2017

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Essential gene profiles in breast, pancreatic, and ovarian cancer cells.

2 October 2017

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MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition

2 October 2017

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Screens, maps & networks: from genome sequences to personalized medicine

2 October 2017

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Mutual exclusivity analysis identifies oncogenic network modules

2 October 2017

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The underlying mechanism for the PARP and BRCA synthetic lethality: clearing up the misunderstandings

2 October 2017

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Integrated genomic analyses of ovarian carcinoma

2 October 2017

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Understanding and predicting synthetic lethal genetic interactions in Saccharomyces cerevisiae using domain genetic interactions

2 October 2017

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GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers

2 October 2017

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2 October 2017

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BRCA1, PARP, and 53BP1: conditional synthetic lethality and synthetic viability

2 October 2017

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Synthetic lethality: General principles, utility and detection using genetic screens in human cells

2 October 2017

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Genetic interactions reveal the evolutionary trajectories of duplicate genes

2 October 2017

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GeneCards Version 3: the human gene integrator

2 October 2017

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Evaluating between-pathway models with expression data

2 October 2017

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An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

2 October 2017

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DRYGIN: a database of quantitative genetic interaction networks in yeast

2 October 2017

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Recent advances in cancer therapy targeting proteins involved in DNA double-strand break repair.

2 October 2017

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Systematic mapping of genetic interaction networks

2 October 2017

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Fault tolerance in protein interaction networks: stable bipartite subgraphs and redundant pathways

2 October 2017

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Principles of cancer therapy: oncogene and non-oncogene addiction

2 October 2017

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Mining protein networks for synthetic genetic interactions

2 October 2017

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Finding friends and enemies in an enemies-only network: a graph diffusion kernel for predicting novel genetic interactions and co-complex membership from yeast genetic interactions

2 October 2017

1 reference

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Modeling synthetic lethality.

2 October 2017

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2 October 2017

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Mapping genetically compensatory pathways from synthetic lethal interactions in yeast

2 October 2017

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Exploring genetic interactions and networks with yeast

2 October 2017

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AKT1, AKT2 and AKT3-dependent cell survival is cell line-specific and knockdown of all three isoforms selectively induces apoptosis in 20 human tumor cell lines

2 October 2017

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The concept of synthetic lethality in the context of anticancer therapy

2 October 2017

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Systematic interpretation of genetic interactions using protein networks

2 October 2017

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

2 October 2017

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Splice variants as cancer biomarkers

2 October 2017

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Conserved pathways within bacteria and yeast as revealed by global protein network alignment

2 October 2017

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How many more breast cancer predisposition genes are there?

2 October 2017

1 reference

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Principles for the buffering of genetic variation

2 October 2017

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Pathway redundancy and protein essentiality revealed in the Saccharomyces cerevisiae interaction networks

2 October 2017

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In silico prediction of synthetic lethality by meta-analysis of genetic interactions, functions, and pathways in yeast and human cancer

2 July 2018

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Systematic tracking of dysregulated modules identifies novel genes in cancer

23 September 2018

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10.1186/S13062-015-0086-1

23 September 2018

Identifiers

DOI

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25 February 2020

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Dimensions Publication ID

0 references

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25 February 2020

PubMed publication ID

26427375

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