The metabotropic glutamate receptor 8 agonist (S)-3,4-DCPG reverses motor deficits in prolonged but not acute models of Parkinson's disease. (Q36203237)

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30 January 2020

title

The metabotropic glutamate receptor 8 agonist (S)-3,4-DCPG reverses motor deficits in prolonged but not acute models of Parkinson's disease (English)

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30 January 2020

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4

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8

P Jeffrey Conn

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30 January 2020

9

Colleen M Niswender

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6

M Sib Ansari

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2

Carrie K Jones

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30 January 2020

author name string

Kari A Johnson

1

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30 January 2020

Mohammed N Tantawy

3

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Marketa Marvanova

5

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Ronald M Baldwin

7

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publication date

21 April 2012

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number of pages

9

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inferred from page(s)

published in

Neuropharmacology

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volume

66

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page(s)

187-195

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A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential

30 January 2020

cites work

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The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease.

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Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate recept

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A novel assay of Gi/o-linked G protein-coupled receptor coupling to potassium channels provides new insights into the pharmacology of the group III metabotropic glutamate receptors

1 October 2017

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Synthesis and biological evaluation of 1-amino-2-phosphonomethylcyclopropanecarboxylic acids, new group III metabotropic glutamate receptor agonists

1 October 2017

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Targeting group III metabotropic glutamate receptors produces complex behavioral effects in rodent models of Parkinson's disease

1 October 2017

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1 October 2017

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1 October 2017

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Metabotropic glutamate receptors in the basal ganglia motor circuit

1 October 2017

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Allosteric modulation of group III metabotropic glutamate receptor 4: A potential approach to Parkinson's disease treatment

1 October 2017

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Pharmacological validation of behavioural measures of akinesia and dyskinesia in a rat model of Parkinson's disease.

1 October 2017

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(S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord

1 October 2017

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Immunohistochemical localization of subtype 4a metabotropic glutamate receptors in the rat and mouse basal ganglia

1 October 2017

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1 October 2017

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22 September 2018

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22 September 2018

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22 September 2018

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22 September 2018

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22 September 2018

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Activation of group III metabotropic glutamate receptors in selected regions of the basal ganglia alleviates akinesia in the reserpine-treated rat.

22 September 2018

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22 September 2018

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22 September 2018

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CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury

22 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22546615

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Identifiers

DOI

10.1016/J.NEUROPHARM.2012.03.029

1 reference

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30 January 2020

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30 January 2020

PubMed publication ID

22546615

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