Signal transduction of oncogenic Flt3. (Q36251180)

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English	Signal transduction of oncogenic Flt3.	scientific article

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Europe PubMed Central

PubMed publication ID

16146838

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13 August 2017

review article

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Europe PubMed Central

title

Signal transduction of oncogenic Flt3. (English)

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PubMed publication ID

16146838

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13 August 2017

author

Carsten Müller-Tidow

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2

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Carsten Müller-Tidow

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author name string

Chunaram Choudhary

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1

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Europe PubMed Central

PubMed publication ID

16146838

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13 August 2017

Wolfgang E Berdel

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3

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Europe PubMed Central

PubMed publication ID

16146838

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13 August 2017

Hubert Serve

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Europe PubMed Central

PubMed publication ID

16146838

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13 August 2017

publication date

1 August 2005

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Europe PubMed Central

PubMed publication ID

16146838

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13 August 2017

published in

International Journal of Hematology

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Europe PubMed Central

PubMed publication ID

16146838

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13 August 2017

volume

82

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Europe PubMed Central

PubMed publication ID

16146838

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13 August 2017

issue

2

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Europe PubMed Central

PubMed publication ID

16146838

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13 August 2017

page(s)

93-99

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Europe PubMed Central

PubMed publication ID

16146838

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13 August 2017

cites work

Identification of a novel activating mutation (Y842C) within the activation loop of FLT3 in patients with acute myeloid leukemia (AML).

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/16146838

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12 December 2020

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FLT3 signaling in hematopoietic cells involves CBL, SHC and an unknown P115 as prominent tyrosine-phosphorylated substrates

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

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12 December 2020

based on heuristic

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Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Internal tandem duplication of FLT3 in relapsed acute myeloid leukemia: a comparative analysis of bone marrow samples from 108 adult patients at diagnosis and relapse

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

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12 December 2020

based on heuristic

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Targeted inhibition of FLT3 overcomes the block to myeloid differentiation in 32Dcl3 cells caused by expression of FLT3/ITD mutations

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

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12 December 2020

based on heuristic

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AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oncogenic kinase signalling

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning of the human homologue of the murine flt3 ligand: a growth factor for early hematopoietic progenitor cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FLT3 receptors with internal tandem duplications promote cell viability and proliferation by signaling through Foxo proteins

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcriptional regulation of granulocyte and monocyte development

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/16146838

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical characterization and analysis of the transforming potential of the FLT3/FLK2 receptor tyrosine kinase

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FLT3 expressing leukemias are selectively sensitive to inhibitors of the molecular chaperone heat shock protein 90 through destabilization of signal transduction-associated kinases.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Src family tyrosine kinases are activated by Flt3 and are involved in the proliferative effects of leukemia-associated Flt3 mutations

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifying and characterizing a novel activating mutation of the FLT3 tyrosine kinase in AML.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the FMS/KIT-like gene FLT3 in human acute leukemias of the myeloid and lymphoid lineages

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the Unite

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flt3 receptor tyrosine kinase as a drug target in leukemia

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substrate specificities and identification of a putative binding site for PI3K in the carboxy tail of the murine Flt3 receptor tyrosine kinase

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Incidence and prognosis of c-KIT and FLT3 mutations in core binding factor (CBF) acute myeloid leukaemias

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FLT3 receptor expression on the surface of normal and malignant human hematopoietic cells

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cotreatment with 17-allylamino-demethoxygeldanamycin and FLT-3 kinase inhibitor PKC412 is highly effective against human acute myelogenous leukemia cells with mutant FLT-3.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Internal tandem duplication of the flt3 gene found in acute myeloid leukemia

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Essential role of signal transducer and activator of transcription (Stat)5a but not Stat5b for Flt3-dependent signaling

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitogenic Signalling and Substrate Specificity of the Flk2/Flt3 Receptor Tyrosine Kinase in Fibroblasts and Interleukin 3-Dependent Hematopoietic Cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective apoptosis of tandemly duplicated FLT3-transformed leukemia cells by Hsp90 inhibitors

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: a study of the AML Study Group Ulm.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The roles of FLT3 in hematopoiesis and leukemia

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/16146838

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of FLT3 in haematopoietic malignancies

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C-kit mutations in core binding factor leukemias

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyrosine phosphorylation regulates maturation of receptor tyrosine kinases

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3).

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of Ras and Raf in intact mammalian cells upon extracellular stimulation

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reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new and recurrent activating length mutation in exon 20 of the FLT3 gene in acute myeloid leukemia

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enforced expression of an Flt3 internal tandem duplication in human CD34+ cells confers properties of self-renewal and enhanced erythropoiesis

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

STAT3 is required for Flt3L-dependent dendritic cell differentiation

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequential protein kinase reactions controlling cell growth and differentiation

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FLT3 ligand regulates apoptosis through AKT-dependent inactivation of transcription factor FoxO3.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity of Cdc25C-associated kinase 1 (C-TAK1): a novel role for Pim-1 at the G2/M cell cycle checkpoint

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterozygous PU.1 mutations are associated with acute myeloid leukemia.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic significance of FLT3 ITD and D835 mutations in AML patients

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive activation of FLT3 stimulates multiple intracellular signal transducers and results in transformation.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A gain-of-function mutation of JAK2 in myeloproliferative disorders

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SHC and SHIP phosphorylation and interaction in response to activation of the FLT3 receptor

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal transducer and activator of transcription proteins in leukemias.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p85 subunit of PI3 kinase does not bind to human Flt3 receptor, but associates with SHP2, SHIP, and a tyrosine-phosphorylated 100-kDa protein in Flt3 ligand-stimulated hematopoietic cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Switching signals on or off by receptor dimerization

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The importance of PU.1 concentration in hematopoietic lineage commitment and maturation

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical relevance of internal tandem duplication of the FLT3 gene in childhood acute myeloid leukemia

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The CBL-related protein CBLB participates in FLT3 and interleukin-7 receptor signal transduction in pro-B cells

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structural basis for autoinhibition of FLT3 by the juxtamembrane domain

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative analysis of MLL partial tandem duplication and FLT3 internal tandem duplication mutations in 956 adult patients with acute myeloid leukemia

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A model of APL with FLT3 mutation is responsive to retinoic acid and a receptor tyrosine kinase inhibitor, SU11657.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the protein encoded by the flt3 (flk2) receptor-like tyrosine kinase gene

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stat5 tetramer formation is associated with leukemogenesis

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of a c-kit product complex reveals the basis for kinase transactivation

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression and Signal Transduction of the FLT3 Tyrosine Kinase Receptor

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Internal tandem duplication mutation of FLT3 blocks myeloid differentiation through suppression of C/EBPα expression

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The phosphoinositide 3-kinase pathway

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of the human stem cell tyrosine kinase-1 gene (FLT3) to 13q12→q13

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive activation of STAT5A promotes human hematopoietic stem cell self-renewal and erythroid differentiation

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Incidence and prognostic value of FLT3 internal tandem duplication and D835 mutations in acute myeloid leukemia

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tandem duplications of the FLT3 receptor gene are associated with leukemic transformation of myelodysplasia

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the hematopoietic growth factor receptor FLT3 (STK-1/Flk2) in human leukemias

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FLT3 mutations in childhood acute lymphoblastic leukemia

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16146838

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1532/IJH97.05090

1 reference

stated in

Europe PubMed Central

PubMed publication ID

16146838

retrieved

13 August 2017

Dimensions Publication ID

1013910593

0 references

PubMed publication ID

16146838

1 reference

stated in

Europe PubMed Central

PubMed publication ID

16146838

retrieved

13 August 2017

 

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