Dysregulated miRNA biogenesis downstream of cellular stress and ALS-causing mutations: a new mechanism for ALS. (Q36270953)

13 August 2017

Dysregulated miRNA biogenesis downstream of cellular stress and ALS-causing mutations: a new mechanism for ALS. (English)

1 reference

amyotrophic lateral sclerosis

13 August 2017

1 reference

Anna Emde

1

1 reference

13 August 2017

Chen Eitan

2

1 reference

13 August 2017

Lee-Loung Liou

3

1 reference

13 August 2017

Ryan T Libby

4

1 reference

13 August 2017

Natali Rivkin

5

1 reference

13 August 2017

Iddo Magen

6

1 reference

13 August 2017

Irit Reichenstein

7

1 reference

13 August 2017

Hagar Oppenheim

8

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13 August 2017

Raya Eilam

9

1 reference

13 August 2017

Aurelio Silvestroni

10

1 reference

13 August 2017

Betty Alajajian

11

1 reference

13 August 2017

Iddo Z Ben-Dov

12

1 reference

13 August 2017

Julianne Aebischer

13

1 reference

13 August 2017

Alon Savidor

14

1 reference

13 August 2017

Yishai Levin

15

1 reference

13 August 2017

Robert Sons

16

1 reference

13 August 2017

Scott M Hammond

17

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13 August 2017

John M Ravits

18

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13 August 2017

Thomas Möller

19

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13 August 2017

Eran Hornstein

20

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13 August 2017

language of work or name

English

0 references

publication date

1 September 2015

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13 August 2017

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13 August 2017

34

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13 August 2017

21

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13 August 2017

2633-2651

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describes a project that uses

13 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4641530/fullTextXML

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Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis

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Identification of microRNAs dysregulated in cellular senescence driven by endogenous genotoxic stress

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Method for widespread microRNA-155 inhibition prolongs survival in ALS-model mice

30 September 2017

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Altered microRNA expression profile in Amyotrophic Lateral Sclerosis: a role in the regulation of NFL mRNA levels

30 September 2017

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Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing

30 September 2017

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EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2.

30 September 2017

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30 September 2017

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A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS.

30 September 2017

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ALS mutant FUS disrupts nuclear localization and sequesters wild-type FUS within cytoplasmic stress granules

30 September 2017

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Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS

30 September 2017

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RNA-binding ability of FUS regulates neurodegeneration, cytoplasmic mislocalization and incorporation into stress granules associated with FUS carrying ALS-linked mutations

30 September 2017

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FUS stimulates microRNA biogenesis by facilitating co-transcriptional Drosha recruitment

30 September 2017

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Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP

30 September 2017

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30 September 2017

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Overexpression of human wild-type FUS causes progressive motor neuron degeneration in an age- and dose-dependent fashion

30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress

30 September 2017

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Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing

30 September 2017

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DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration

30 September 2017

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TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1.

30 September 2017

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Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice

30 September 2017

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TDP-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor

30 September 2017

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30 September 2017

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Tar DNA Binding Protein-43 (TDP-43) Associates with Stress Granules: Analysis of Cultured Cells and Pathological Brain Tissue

30 September 2017

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Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules

30 September 2017

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Nuclear localization sequence of FUS and induction of stress granules by ALS mutants.

30 September 2017

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miRNA malfunction causes spinal motor neuron disease

30 September 2017

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ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import

30 September 2017

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Nuclear factor TDP-43 can affect selected microRNA levels

30 September 2017

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eIF5A promotes translation elongation, polysome disassembly and stress granule assembly

30 September 2017

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30 September 2017

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TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration

30 September 2017

1 reference

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Eukaryotic stress granules: the ins and outs of translation

30 September 2017

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Sporadic ALS has compartment-specific aberrant exon splicing and altered cell-matrix adhesion biology

30 September 2017

1 reference

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TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration

30 September 2017

1 reference

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No benefit from chronic lithium dosing in a sibling-matched, gender balanced, investigator-blinded trial using a standard mouse model of familial ALS

30 September 2017

1 reference

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RNA granules: post-transcriptional and epigenetic modulators of gene expression

30 September 2017

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Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6

30 September 2017

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Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis

30 September 2017

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miRNA in situ hybridization in formaldehyde and EDC-fixed tissues

30 September 2017

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Assessing gait impairment following experimental traumatic brain injury in mice

30 September 2017

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Prolyl 4-hydroxylation regulates Argonaute 2 stability

30 September 2017

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A small molecule enhances RNA interference and promotes microRNA processing.

30 September 2017

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A cytosolic iron chaperone that delivers iron to ferritin.

30 September 2017

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Autoinhibition of human dicer by its internal helicase domain

30 September 2017

1 reference

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Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies

30 September 2017

1 reference

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TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

30 September 2017

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TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis

30 September 2017

1 reference

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Stress granules: the Tao of RNA triage

30 September 2017

1 reference

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TDP-43 A315T mutation in familial motor neuron disease

30 September 2017

1 reference

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Design, power, and interpretation of studies in the standard murine model of ALS

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4641530

Identification of PCBP2, a facilitator of IRES-mediated translation, as a novel constituent of stress granules and processing bodies

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4641530

eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4641530

Quantitative analysis of Argonaute protein reveals microRNA-dependent localization to stress granules

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4641530

Canalization of development by microRNAs

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4641530

The role of PACT in the RNA silencing pathway

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4641530

Real-time expression profiling of microRNA precursors in human cancer cell lines

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4641530

TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4641530

TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4641530

Stress granules and processing bodies are dynamically linked sites of mRNP remodeling

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4641530

The Microprocessor complex mediates the genesis of microRNAs

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4641530

Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4641530

Dynamic shuttling of TIA-1 accompanies the recruitment of mRNA to mammalian stress granules

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4641530

RNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 alpha to the assembly of mammalian stress granules

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4641530

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4641530

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4641530

Dissociation of mammalian polyribosomes into subunits by puromycin

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4641530

MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4641530

miR-338-3p is over-expressed in blood, CFS, serum and spinal cord from sporadic amyotrophic lateral sclerosis patients.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4641530

Premature death of TDP-43 (A315T) transgenic mice due to gastrointestinal complications prior to development of full neurological symptoms of amyotrophic lateral sclerosis.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4641530

Detection of a novel frameshift mutation and regions with homozygosis within ARHGEF28 gene in familial amyotrophic lateral sclerosis

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4641530

Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS).

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4641530

A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4641530

Selective localization of PCBP2 to cytoplasmic processing bodies.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4641530

Absence of heterogeneous nuclear ribonucleoproteins and survival motor neuron protein in TDP-43 positive inclusions in frontotemporal lobar degeneration

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4641530

Persistent activation of p38 mitogen-activated protein kinase in a mouse model of familial amyotrophic lateral sclerosis correlates with disease progression.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4641530

Human Cu/Zn superoxide dismutase (SOD1) overexpression in mice causes mitochondrial vacuolization, axonal degeneration, and premature motoneuron death and accelerates motoneuron disease in mice expressing a familial amyotrophic lateral sclerosis mut

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4641530

An ALS-associated mutation in the FUS 3'-UTR disrupts a microRNA-FUS regulatory circuitry

22 September 2018

1 reference

12 December 2020

eIF2alpha kinases provide a new solution to the puzzle of substrate specificity

1 reference

12 December 2020

Novel missense and truncating mutations in FUS/TLS in familial ALS

1 reference

12 December 2020

microRNAs: a safeguard against turmoil?

1 reference

12 December 2020

Identifiers

DOI

10.15252/EMBJ.201490493

1 reference

release_gja2pvamm5gulo6b5rsxw6qjxu

13 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/gja2pvamm5gulo6b5rsxw6qjxu

24 November 2022

mapped directly with Wikidata item

1 reference

13 August 2017

PubMed publication ID

26330466

1 reference