A phase I trial of two sequence-specific schedules of decitabine and vorinostat in patients with acute myeloid leukemia. (Q36395421)

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29 February 2020

title

A phase I trial of two sequence-specific schedules of decitabine and vorinostat in patients with acute myeloid leukemia (English)

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29 February 2020

main subject

phase I clinical trial

0 references

author

Aaron Schimmer

7

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29 February 2020

Vikas Gupta

8

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29 February 2020

15

Richard Piekarz

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29 February 2020

author name string

Jonathan How

1

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29 February 2020

Mark D Minden

2

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29 February 2020

Leber Brian

3

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29 February 2020

Eric X Chen

4

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29 February 2020

Joseph Brandwein

5

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29 February 2020

Andre C Schuh

6

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Sheila Webster

9

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Tammy Degelder

10

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29 February 2020

Patricia Haines

11

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29 February 2020

Lee-Anne Stayner

12

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Shauna McGill

13

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Lisa Wang

14

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29 February 2020

Tracy Wong

16

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29 February 2020

Lillian L Siu

17

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29 February 2020

Igor Espinoza-Delgado

18

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29 February 2020

Julianne L Holleran

19

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29 February 2020

Merrill J Egorin

20

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Karen W L Yee

21

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publication date

30 March 2015

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29 February 2020

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29 February 2020

volume

56

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29 February 2020

issue

10

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29 February 2020

page(s)

2793-2802

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Multicenter, randomized, open-label, phase III trial of decitabine versus patient choice, with physician advice, of either supportive care or low-dose cytarabine for the treatment of older patients with newly diagnosed acute myeloid leukemia

29 February 2020

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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A phase 1 clinical trial of vorinostat in combination with decitabine in patients with acute myeloid leukaemia or myelodysplastic syndrome.

28 June 2018

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Low-dose decitabine versus best supportive care in elderly patients with intermediate- or high-risk myelodysplastic syndrome (MDS) ineligible for intensive chemotherapy: final results of the randomized phase III study of the European Organisation fo

21 September 2018

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Characterization of decomposition products and preclinical and low dose clinical pharmacokinetics of decitabine (5-aza-2'-deoxycytidine) by a new liquid chromatography/tandem mass spectrometry quantification method

21 September 2018

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Pilot study of combination transcriptional modulation therapy with sodium phenylbutyrate and 5-azacytidine in patients with acute myeloid leukemia or myelodysplastic syndrome.

21 September 2018

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Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in hematopoietic malignancies

21 September 2018

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Antineoplastic action of 5-aza-2'-deoxycytidine and phenylbutyrate on human lung carcinoma cells

21 September 2018

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21 September 2018

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DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors.

21 September 2018

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21 September 2018

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Phase I study of decitabine in combination with vorinostat in patients with advanced solid tumors and non-Hodgkin's lymphomas

21 September 2018

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12 December 2020

DNA methylation changes after 5-aza-2'-deoxycytidine therapy in patients with leukemia

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12 December 2020

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12 December 2020

A liquid chromatography-electrospray ionization tandem mass spectrometric assay for quantitation of the histone deacetylase inhibitor, vorinostat (suberoylanilide hydroxamicacid, SAHA), and its metabolites in human serum

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12 December 2020

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12 December 2020

Down-regulation of human DNA-(cytosine-5) methyltransferase induces cell cycle regulators p16(ink4A) and p21(WAF/Cip1) by distinct mechanisms

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12 December 2020

The fundamental role of epigenetic events in cancer

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12 December 2020

10.3109/10428194.2015.1018248

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25682963%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25682963%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

PubMed publication ID

25682963

1 reference