Gene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity. (Q36399327)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15492124%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

title

Gene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity (English)

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4 January 2020

1

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4 January 2020

Daniel H Gray

2

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4 January 2020

Sylvie Lesage

3

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4 January 2020

Anne L. Fletcher

4

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4 January 2020

Hamish S. Scott

7

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4 January 2020

Chris Goodnow

10

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4 January 2020

author name string

Judith Wilson

5

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4 January 2020

Kylie E Webster

6

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4 January 2020

Richard L Boyd

8

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4 January 2020

Leena Peltonen

9

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4 January 2020

language of work or name

English

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publication date

1 October 2004

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Journal of Experimental Medicine

4 January 2020

published in

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4 January 2020

volume

200

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4 January 2020

issue

8

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4 January 2020

page(s)

1015-1026

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Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome: time to review diagnostic criteria?

4 January 2020

cites work

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Aire regulates negative selection of organ-specific T cells

30 September 2017

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Failure to censor forbidden clones of CD4 T cells in autoimmune diabetes.

30 September 2017

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Projection of an immunological self shadow within the thymus by the aire protein

30 September 2017

1 reference

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CD4+ CD25+ suppressor T cells: more questions than answers

30 September 2017

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Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature enterocytes to produce insulin

30 September 2017

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Aire deficient mice develop multiple features of APECED phenotype and show altered immune response

30 September 2017

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Analysis of thymic stromal cell populations using flow cytometry

30 September 2017

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Phenotypic and functional analysis of CD8(+) T cells undergoing peripheral deletion in response to cross-presentation of self-antigen.

30 September 2017

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The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein

30 September 2017

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High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: mechanisms of selection of the self-reactive repertoire

30 September 2017

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Mutations in the AIRE gene: effects on subcellular location and transactivation function of the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy protein

30 September 2017

1 reference

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Localization of the APECED protein in distinct nuclear structures

30 September 2017

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The Fas/Fas ligand pathway and Bcl-2 regulate T cell responses to model self and foreign antigens

30 September 2017

1 reference

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An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

30 September 2017

1 reference

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Positional cloning of the APECED gene

30 September 2017

1 reference

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Self-reactive B cells are not eliminated or inactivated by autoantigen expressed on thyroid epithelial cells.

30 September 2017

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The thymus and self-tolerance: co-existence of encephalitogenic S100 beta-specific T cells and their nominal autoantigen in the normal adult rat thymus

30 September 2017

1 reference

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The thymic repertoire of neuroendocrine self-antigens: physiological implications in T-cell life and death.

30 September 2017

1 reference

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Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells.

30 September 2017

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Pathogenesis of myasthenia gravis. Acetylcholine receptor-related antigenic determinants in tumor-free thymuses and thymic epithelial tumors

30 September 2017

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Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens

30 September 2017

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Evidence for a thymus-dependent form of tolerance that is not based on elimination or anergy of reactive T cells

30 September 2017

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Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.

30 September 2017

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Clinical review 93: Autoimmune polyglandular syndrome type 1.

30 September 2017

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Aberrant expression of tissue-specific proteins in the thymus: a hypothesis for the development of central tolerance

28 June 2018

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The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.

28 June 2018

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Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus.

28 June 2018

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Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice

28 June 2018

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T cell tolerance to a neo-self antigen expressed by thymic epithelial cells: the soluble form is more effective than the membrane-bound form

28 June 2018

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Immunological findings in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) and their family members: are heterozygotes subclinically affected?

21 September 2018

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Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.

21 September 2018

1 reference

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Organ-specific and non-organ-specific autoantibodies in children and young adults with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).

21 September 2018

1 reference

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Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells.

21 September 2018

1 reference

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Autoimmune regulator is expressed in the cells regulating immune tolerance in thymus medulla.

21 September 2018

1 reference

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Peripheral-antigen-expressing cells in thymic medulla: factors in self-tolerance and autoimmunity

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211852

A range of CD4 T cell tolerance: partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis.

21 September 2018

1 reference

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CTLA-4 regulates induction of anergy in vivo

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211852

RNA and protein expression of the murine autoimmune regulator gene (Aire) in normal, RelB-deficient and in NOD mouse

21 October 2018

1 reference

12 December 2020

Age-dependent T cell tolerance and autoimmunity to myelin basic protein

1 reference

12 December 2020

Successful allotransplantation of mouse pancreatic islets to nonimmunosuppressed recipients

1 reference

12 December 2020

Mapping the antigenic epitope for a monoclonal antibody against lysozyme

1 reference

12 December 2020

Autoimmune polyendocrinopathy--candidosis--ectodermal dystrophy (APECED): autosomal recessive inheritance

1 reference

12 December 2020

Thymic expression of myelin basic protein (MBP). Activation of MBP-specific T cells by thymic cells in the absence of exogenous MBP

1 reference

12 December 2020

Thymic expression of autoantigens correlates with resistance to autoimmune disease

1 reference

12 December 2020

Intrathymic expression of genes involved in organ specific autoimmune disease

1 reference

12 December 2020

Transcription of a broad range of self-antigens in human thymus suggests a role for central mechanisms in tolerance toward peripheral antigens

1 reference

12 December 2020

Mutational analysis of the autoimmune regulator (AIRE) gene in sporadic autoimmune Addison's disease can reveal patients with unidentified autoimmune polyendocrine syndrome type I

1 reference

12 December 2020

Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes

1 reference

12 December 2020

Tolerance induction to self antigens by peripheral dendritic cells

1 reference

12 December 2020

Heterozygous null mutation of myelin P0 protein enhances susceptibility to autoimmune neuritis targeting P0 peptide

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20040581

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15492124%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

1 reference

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4 January 2020

PubMed publication ID

15492124

1 reference