A mutant alpha subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cells (Q36428968)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8393576%20AND%20SRC:MED&resulttype=core&format=json

11 October 2019

title

A mutant alpha subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cells (English)

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11 October 2019

4

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11 October 2019

author name string

N Xu

series ordinal

1

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11 October 2019

L Bradley

series ordinal

2

1 reference

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11 October 2019

I Ambdukar

series ordinal

3

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11 October 2019

language of work or name

English

0 references

publication date

1 July 1993

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Proceedings of the National Academy of Sciences of the United States of America

11 October 2019

published in

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11 October 2019

volume

90

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11 October 2019

issue

14

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11 October 2019

page(s)

6741-6745

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Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product

11 October 2019

cites work

1 reference

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Construction and applications of a highly transmissible murine retrovirus shuttle vector

30 September 2017

1 reference

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Murine sarcoma and leukemia viruses: assay using clonal lines of contact-inhibited mouse cells

30 September 2017

1 reference

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A new generation of Ca2+ indicators with greatly improved fluorescence properties

30 September 2017

1 reference

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G proteins: transducers of receptor-generated signals

30 September 2017

1 reference

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Arachidonic acid metabolism

30 September 2017

1 reference

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Stimulation of arachidonic acid release and inhibition of mitogenesis by cloned genes for muscarinic receptor subtypes stably expressed in A9 L cells

30 September 2017

1 reference

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Site-directed mutagenesis by overlap extension using the polymerase chain reaction

30 September 2017

1 reference

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Ectopic expression of the serotonin 1c receptor and the triggering of malignant transformation

30 September 2017

1 reference

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Receptor-mediated activation of phospholipase A2 and arachidonic acid release in signal transduction

30 September 2017

1 reference

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Two G protein oncogenes in human endocrine tumors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47008

G alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47008

Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47008

The GTPase superfamily: conserved structure and molecular mechanism

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47008

Regulators and Effectors of ras Proteins

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47008

G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47008

Activating and inactivating mutations of the alpha subunit of Gi2 protein have opposite effects on proliferation of NIH 3T3 cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47008

A mutant alpha subunit of Gi2 induces neoplastic transformation of Rat-1 cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47008

Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47008

Activation of phospholipase C by the alpha subunits of the Gq and G11 proteins in transfected Cos-7 cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47008

Increased mitogenic responsiveness of Swiss 3T3 cells expressing constitutively active Gs alpha

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47008

Regulation of Ras-GAP and the neurofibromatosis-1 gene product by eicosanoids

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47008

The G226A mutant of Gs alpha highlights the requirement for dissociation of G protein subunits

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47008

Mastoparan, a novel mitogen for Swiss 3T3 cells, stimulates pertussis toxin-sensitive arachidonic acid release without inositol phosphate accumulation

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47008

Activation of the β1 isozyme of phospholipase C by α subunits of the Gq class of G proteins

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47008

Fc epsilon RI-induced protein tyrosine phosphorylation of pp72 in rat basophilic leukemia cells (RBL-2H3). Evidence for a novel signal transduction pathway unrelated to G protein activation and phosphatidylinositol hydrolysis.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=47008

28 June 2018

Identifiers

DOI

10.1073/PNAS.90.14.6741

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8393576%20AND%20SRC:MED&resulttype=core&format=json

11 October 2019

0 references

release_jfh4jqrshjcvfoecygswqjdczy

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/jfh4jqrshjcvfoecygswqjdczy

mapped directly with Wikidata item

24 November 2022

based on heuristic

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11 October 2019

PubMed publication ID

8393576

1 reference