The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging (Q36449196)

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29 December 2019

title

The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging (English)

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29 December 2019

1 reference

0 references

8

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14

Oleh Hornykiewicz

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1

Luigi Zecca

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29 December 2019

author name string

Antonella Stroppolo

2

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29 December 2019

Alberto Gatti

3

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29 December 2019

Davide Tampellini

4

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Marco Toscani

5

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29 December 2019

Mario Gallorini

6

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29 December 2019

Giuseppe Giaveri

7

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Paolo Santambrogio

9

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29 December 2019

Ruggero G Fariello

10

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Erdem Karatekin

11

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Mark H Kleinman

12

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29 December 2019

Nicholas Turro

13

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Fabio A Zucca

15

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29 December 2019

language of work or name

English

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publication date

21 June 2004

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Proceedings of the National Academy of Sciences of the United States of America

29 December 2019

published in

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volume

101

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issue

26

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page(s)

9843-9848

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Neuromelanin of the substantia nigra: a neuronal black hole with protective and toxic characteristics

29 December 2019

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Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure

30 September 2017

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Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

30 September 2017

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A quantitative analysis of isoferritins in select regions of aged, parkinsonian, and Alzheimer's diseased brains

30 September 2017

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Disease-specific patterns of locus coeruleus cell loss

30 September 2017

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30 September 2017

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Regional topography within noradrenergic locus coeruleus as revealed by retrograde transport of horseradish peroxidase

30 September 2017

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Alterations in m-RNA expression for Cu,Zn-superoxide dismutase and glutathione peroxidase in the basal ganglia of MPTP-treated marmosets and patients with Parkinson's disease

30 September 2017

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Increased regional brain concentrations of ceruloplasmin in neurodegenerative disorders

28 June 2018

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Iron and other metals in neuromelanin, substantia nigra, and putamen of human brain

28 June 2018

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The effect of a synthetic neuromelanin on yield of free hydroxyl radicals generated in model systems

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Selectivity of the parkinsonian neurotoxin MPTP: toxic metabolite MPP+ binds to neuromelanin

28 June 2018

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28 June 2018

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Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease

28 June 2018

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28 June 2018

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28 June 2018

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A new major projection from locus coeruleus: the main source of noradrenergic nerve terminals in the ventral and dorsal columns of the spinal cord

28 June 2018

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28 June 2018

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21 September 2018

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Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease

21 September 2018

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Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases

21 September 2018

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Activation of microglia by human neuromelanin is NF-kappaB dependent and involves p38 mitogen-activated protein kinase: implications for Parkinson's disease

21 September 2018

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1-Methyl-4-phenylpyridinium (MPP+)-induced apoptosis and mitochondrial oxidant generation: role of transferrin-receptor-dependent iron and hydrogen peroxide

21 September 2018

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Ceruloplasmin regulates iron levels in the CNS and prevents free radical injury.

21 September 2018

1 reference

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Total and paramagnetic metals in human substantia nigra and its neuromelanin

21 September 2018

1 reference

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Studies on neuromelanin: II. Melanin in the brainstems of infants and children

21 September 2018

1 reference

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The neuropathologic basis of different clinical subgroups of Parkinson's disease

21 September 2018

1 reference

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Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain

21 September 2018

1 reference

12 December 2020

Transition Metals, Ferritin, Glutathione, and Ascorbic Acid in Parkinsonian Brains

1 reference

12 December 2020

Autoradiography of [14C]paraquat or [14C]diquat in frogs and mice: accumulation in neuromelanin

1 reference

12 December 2020

A selective increase in particulate superoxide dismutase activity in parkinsonian substantia nigra

1 reference

12 December 2020

Image analyser-assisted morphometry of the locus coeruleus in Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis

1 reference

12 December 2020

Interaction of neuromelanin and iron in substantia nigra and other areas of human brain

1 reference

12 December 2020

Binding of iron to neuromelanin of human substantia nigra and synthetic melanin: an electron paramagnetic resonance spectroscopy study

1 reference

12 December 2020

1 reference

12 December 2020

Changes of copper-transporting proteins and ceruloplasmin in the lentiform nuclei in primary adult-onset dystonia

1 reference

12 December 2020

The absolute concentration of nigral neuromelanin, assayed by a new sensitive method, increases throughout the life and is dramatically decreased in Parkinson's disease

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0403495101

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15210960%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

0 references

1 reference

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29 December 2019

PubMed publication ID

15210960

1 reference