Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications (Q36659535)

15 August 2017

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title

Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications (English)

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15 August 2017

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Andrea Williams

1

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15 August 2017

Luca Jahreiss

2

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15 August 2017

Sovan Sarkar

3

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15 August 2017

Shinji Saiki

4

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15 August 2017

Fiona M Menzies

5

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15 August 2017

Brinda Ravikumar

6

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15 August 2017

David C Rubinsztein

7

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15 August 2017

language of work or name

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1 January 2006

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Current Topics in Developmental Biology

15 August 2017

published in

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15 August 2017

volume

76

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15 August 2017

page(s)

89-101

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Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

15 August 2017

cites work

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Rapamycin alleviates toxicity of different aggregate-prone proteins

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Neural and developmental actions of lithium: a unifying hypothesis

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The TOR pathway: a target for cancer therapy

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Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: a North Central Cancer Treatment Group Study

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Protein degradation and protection against misfolded or damaged proteins

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7 January 2021

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Regulation of Membrane Protein Transport by Ubiquitin and Ubiquitin-Binding Proteins

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7 January 2021

Inefficient degradation of truncated polyglutamine proteins by the proteasome

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7 January 2021

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

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7 January 2021

Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation

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7 January 2021

Autophagy, cytoplasm-to-vacuole targeting pathway, and pexophagy in yeast and mammalian cells.

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7 January 2021

Vacuolar import of proteins and organelles from the cytoplasm

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7 January 2021

Sirolimus: its role in nephrology.

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Development by self-digestion: molecular mechanisms and biological functions of autophagy

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7 January 2021

Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions

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7 January 2021

Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity

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7 January 2021

Pathophysiology of chaperone-mediated autophagy

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7 January 2021

CREB-binding protein sequestration by expanded polyglutamine

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7 January 2021

Methods for monitoring autophagy

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SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein

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Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity

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7 January 2021

Autophagy regulates the processing of amino terminal huntingtin fragments

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7 January 2021

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

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7 January 2021

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

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7 January 2021

Rapamycin pre-treatment protects against apoptosis

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7 January 2021

Autophagy in the eukaryotic cell

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7 January 2021

Huntingtin localization in brains of normal and Huntington's disease patients

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7 January 2021

Lithium induces autophagy by inhibiting inositol monophosphatase

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7 January 2021

Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1

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7 January 2021

Approaching the molecular mechanism of autophagy

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7 January 2021

Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins

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7 January 2021

Aggregate formation inhibits proteasomal degradation of polyglutamine proteins.

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7 January 2021

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

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7 January 2021

Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.

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7 January 2021

A common mechanism of action for three mood-stabilizing drugs

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7 January 2021

TOR signaling in growth and metabolism

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7 January 2021

Autophagy: molecular machinery for self-eating

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7 January 2021

Glutamine repeats and neurodegeneration

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7 January 2021

10.1016/S0070-2153(06)76003-3

Identifiers

DOI

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15 August 2017

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