Molecular and metabolic mechanisms of cardiac dysfunction in diabetes. (Q36674142)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23147391%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

title

Molecular and metabolic mechanisms of cardiac dysfunction in diabetes (English)

1 reference

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17 February 2020

3

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17 February 2020

author name string

Chirag H Mandavia

series ordinal

1

1 reference

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17 February 2020

Annayya R Aroor

series ordinal

2

1 reference

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17 February 2020

James R Sowers

series ordinal

4

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17 February 2020

language of work or name

English

0 references

publication date

9 November 2012

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17 February 2020

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17 February 2020

volume

92

1 reference

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17 February 2020

issue

11

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17 February 2020

page(s)

601-608

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Insulin resistance and heart failure: molecular mechanisms

17 February 2020

cites work

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Over-nutrition and metabolic cardiomyopathy

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Peroxisome proliferator-activated receptor (PPAR α/γ) agonists as a potential target to reduce cardiovascular risk in diabetes

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The Role of Overweight and Obesity in the Cardiorenal Syndrome

30 September 2017

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The Impact of Overnutrition on Insulin Metabolic Signaling in the Heart and the Kidney

30 September 2017

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Interaction between Adiponectin and Aldosterone

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Aldosterone and aldosterone antagonists in cardiac disease: what is known, what is new.

30 September 2017

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Targeting cardiac fibrosis: a new frontier in antiarrhythmic therapy?

30 September 2017

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Inflammation and type 2 diabetes

30 September 2017

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Extrarenal effects of aldosterone.

30 September 2017

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Endoplasmic reticulum stress and lipid metabolism: mechanisms and therapeutic potential

30 September 2017

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Role of differential signaling pathways and oxidative stress in diabetic cardiomyopathy

30 September 2017

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Activation of mTOR/p70S6 kinase by ANG II inhibits insulin-stimulated endothelial nitric oxide synthase and vasodilation

30 September 2017

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Cardiac insulin resistance and microRNA modulators

30 September 2017

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Optimization of cardiac metabolism in heart failure

30 September 2017

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Diabetic cardiomyopathy and oxidative stress: role of antioxidants

30 September 2017

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Vascular smooth muscle insulin resistance, but not hypertrophic signaling, is independent of angiotensin II-induced IRS-1 phosphorylation by JNK

30 September 2017

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The renin-angiotensin-aldosterone system and glucose homeostasis

30 September 2017

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30 September 2017

Insulin and the heart

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Adaptive mechanisms to compensate for overnutrition-induced cardiovascular abnormalities

30 September 2017

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Lipotoxicity in type 2 diabetic cardiomyopathy

30 September 2017

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Interaction between mitochondria and the endoplasmic reticulum: implications for the pathogenesis of type 2 diabetes mellitus

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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The role of oxidative stress in the metabolic syndrome.

30 September 2017

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Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes

30 September 2017

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Mineralocorticoid receptor blockade improves diastolic function independent of blood pressure reduction in a transgenic model of RAAS overexpression.

30 September 2017

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Redox signaling in cardiac myocytes.

30 September 2017

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Reduced cardioprotective action of adiponectin in high-fat diet-induced type II diabetic mice and its underlying mechanisms.

30 September 2017

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A CD36-dependent pathway enhances macrophage and adipose tissue inflammation and impairs insulin signalling

30 September 2017

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Endoplasmic reticulum stress as a therapeutic target in cardiovascular disease

30 September 2017

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Mitochondrial biogenesis in the metabolic syndrome and cardiovascular disease.

30 September 2017

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Salt, aldosterone, and insulin resistance: impact on the cardiovascular system

30 September 2017

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30 September 2017

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Requirement for distinct vesicle-associated membrane proteins in insulin- and AMP-activated protein kinase (AMPK)-induced translocation of GLUT4 and CD36 in cultured cardiomyocytes

30 September 2017

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Imaging myocardial metabolic remodeling

30 September 2017

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Best strategies for hypertension management in type 2 diabetes and obesity

30 September 2017

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Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults

30 September 2017

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Nebivolol improves diastolic dysfunction and myocardial remodeling through reductions in oxidative stress in the Zucker obese rat.

30 September 2017

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30 September 2017

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Rescue of cardiomyopathy in peroxisome proliferator-activated receptor-alpha transgenic mice by deletion of lipoprotein lipase identifies sources of cardiac lipids and peroxisome proliferator-activated receptor-alpha activators

30 September 2017

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10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study

30 September 2017

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The evolving story of the RAAS in hypertension, diabetes and CV disease: moving from macrovascular to microvascular targets

30 September 2017

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Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation

30 September 2017

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The Randle cycle revisited: a new head for an old hat.

30 September 2017

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Angiotensin II: a regulator of cardiomyocyte function and survival

30 September 2017

1 reference

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Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase

30 September 2017

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Feed-forward signaling of TNF-alpha and NF-kappaB via IKK-beta pathway contributes to insulin resistance and coronary arteriolar dysfunction in type 2 diabetic mice

30 September 2017

1 reference

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Mineralocorticoid receptor antagonism attenuates glomerular filtration barrier remodeling in the transgenic Ren2 rat.

30 September 2017

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Cellular fatty acid uptake: a pathway under construction

30 September 2017

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Angiotensin II and the development of insulin resistance: implications for diabetes

30 September 2017

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Cardiac metabolism in diabetes mellitus

30 September 2017

1 reference

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S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2

30 September 2017

1 reference

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Interplay between impaired calcium regulation and insulin signaling abnormalities in diabetic cardiomyopathy

30 September 2017

1 reference

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Cardiac remodeling in obesity.

30 September 2017

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Role of mitochondrial dysfunction in insulin resistance

30 September 2017

1 reference

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Renin-angiotensin-aldosterone system and oxidative stress in cardiovascular insulin resistance.

30 September 2017

1 reference

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Signal integration in the endoplasmic reticulum unfolded protein response

30 September 2017

1 reference

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Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-alpha/PGC-1alpha gene regulatory pathway.

30 September 2017

1 reference

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Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death

30 September 2017

1 reference

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Aldosterone upregulates connective tissue growth factor gene expression via p38 MAPK pathway and mineralocorticoid receptor in ventricular myocytes

30 September 2017

1 reference

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Myocardial redox stress and remodeling in metabolic syndrome, type 2 diabetes mellitus, and congestive heart failure.

30 September 2017

1 reference

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Aldosterone-induced inflammation in the rat heart : role of oxidative stress

30 September 2017

1 reference

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Molecular signalling mechanisms controlling growth and function of cardiac fibroblasts

30 September 2017

1 reference

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Aldosterone inhibits insulin-induced glucose uptake by degradation of insulin receptor substrate (IRS) 1 and IRS2 via a reactive oxygen species-mediated pathway in 3T3-L1 adipocytes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594135

Differential adipose tissue inflammatory state in obese nondiabetic Zucker fatty rats compared to obese diabetic zucker diabetic fatty rats.

28 June 2018

1 reference

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Angiotensin-converting enzyme-2 overexpression improves left ventricular remodeling and function in a rat model of diabetic cardiomyopathy

20 September 2018

1 reference

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The role of oxidative stress in diabetic cardiomyopathy: an experimental study.

20 September 2018

1 reference

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Angiotensin II signalling and calcineurin in cardiac fibroblasts: differential effects of calcineurin inhibitors FK506 and cyclosporine A.

20 September 2018

1 reference

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Modulation of AT-1R/AMPK-MAPK cascade plays crucial role for the pathogenesis of diabetic cardiomyopathy in transgenic type 2 diabetic (Spontaneous Diabetic Torii) rats.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594135

Association of imaging markers of myocardial fibrosis with metabolic and functional disturbances in early diabetic cardiomyopathy.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594135

Aldosterone and cortisol predict medium-term left ventricular remodelling following myocardial infarction.

20 September 2018

1 reference

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Angiotensin II type 1 receptor blocker attenuates diabetes-induced atrial structural remodeling.

20 September 2018

1 reference

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Absence of fatty acid transporter CD36 protects against Western-type diet-related cardiac dysfunction following pressure overload in mice

20 September 2018

1 reference

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Left ventricle structural remodelling in the prediabetic Goto-Kakizaki rat.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594135

Angiotensin II type 1 receptor-dependent oxidative stress mediates endothelial dysfunction in type 2 diabetic mice

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594135

Aldosterone-induced activation of signaling pathways requires activity of angiotensin type 1a receptors

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594135

NF-kappaB activation is required for adaptive cardiac hypertrophy.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594135

Impact of the renin-angiotensin-aldosterone-system on cardiovascular and renal complications in diabetes mellitus

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594135

Left ventricular remodeling after acute myocardial infarction: does eplerenone have an effect?

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594135

Increased aldosterone levels in a model of type 2 diabetes mellitus

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594135

Methods in the evaluation of cardiovascular renin angiotensin aldosterone activation and oxidative stress

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594135

Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594135

Mortality trends in men and women with diabetes, 1971 to 2000.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594135

Aldosterone stimulates matrix metalloproteinases and reactive oxygen species in adult rat ventricular cardiomyocytes

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594135

Aldosterone stimulates proliferation of cardiac fibroblasts by activating Ki-RasA and MAPK1/2 signaling

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594135

Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and aminoimidazole-4-carboxamide-1-beta-D-riboside (AICAR)-stimulated glucose transport

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594135

Metabolic characterization of volume overload heart failure due to aorto-caval fistula in rats

20 September 2018

1 reference

12 December 2020

Redox imbalance in diabetes

1 reference

12 December 2020

Diabetic cardiomyopathy--fact or fiction?

1 reference

12 December 2020

Aldosterone/NaCl-induced renal and cardiac fibrosis is modulated by TGF-β responsiveness of T cells

1 reference

12 December 2020

Involvement of the endothelin and nitric oxide systems in the pathogenesis of renal ischemic damage in an experimental diabetic model

1 reference

12 December 2020

Aldosterone suppresses insulin signaling via the downregulation of insulin receptor substrate-1 in vascular smooth muscle cells

1 reference

12 December 2020

Relationship of diabetes with cardiovascular disease-related hospitalization rates, length of stay, and charges: analysis by race/ethnicity, age, and sex

1 reference

12 December 2020

Interaction Between Insulin and Estradiol in Regulation of Cardiac Glucose and Free Fatty Acid Transporters

1 reference

12 December 2020

Monocyte chemoattractant protein-1 is related to metabolic syndrome and homocysteine in subjects without clinically significant atherosclerotic cardiovascular disease

1 reference

12 December 2020

10.1016/J.LFS.2012.10.028

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23147391%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23147391%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

PubMed publication ID

23147391

1 reference