Methylation-Enhanced Binding of Sp1 to the Stage Selector Element of the Human γ-Globin Gene Promoter May Regulate Development Specificity of Expression (Q36685090)

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scientific article published on June 1, 1993

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English	Methylation-Enhanced Binding of Sp1 to the Stage Selector Element of the Human γ-Globin Gene Promoter May Regulate Development Specificity of Expression	scientific article published on June 1, 1993

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scholarly article

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Europe PubMed Central

PMC publication ID

15 August 2017

Methylation-enhanced binding of Sp1 to the stage selector element of the human gamma-globin gene promoter may regulate development specificity of expression (English)

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Europe PubMed Central

PMC publication ID

15 August 2017

Methylation-Enhanced Binding of Sp1 to the Stage Selector Element of the Human γ-Globin Gene Promoter May Regulate Development Specificity of Expression (English)

1 reference

10.1128/MCB.13.6.3272-3281.1993

https://api.crossref.org/works/10.1128/MCB.13.6.3272-3281.1993

16 August 2024

regulation of gene expression

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16 August 2024

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S. M. Jane

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D. L. Gumucio

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P. A. Ney

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J. M. Cunningham

4

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A. W. Nienhuis

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1 June 1993

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15 August 2017

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http://mcb.asm.org/cgi/content/abstract/13/6/3272

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/7684493/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/7684493/pdf/?tool=EBI

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16 August 2024

https://europepmc.org/articles/PMC359778

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7684493

16 August 2024

https://europepmc.org/articles/PMC359778?pdf=render

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Europe PubMed Central

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16 August 2024

https://journals.asm.org/doi/pdf/10.1128/mcb.13.6.3272-3281.1993

1 reference

10.1128/MCB.13.6.3272-3281.1993

https://api.crossref.org/works/10.1128/MCB.13.6.3272-3281.1993

16 August 2024

https://www.tandfonline.com/doi/pdf/10.1128/mcb.13.6.3272-3281.1993

1 reference

10.1128/MCB.13.6.3272-3281.1993

https://api.crossref.org/works/10.1128/MCB.13.6.3272-3281.1993

16 August 2024

Molecular and Cellular Biology

1 reference

Europe PubMed Central

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15 August 2017

13

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Europe PubMed Central

PMC publication ID

15 August 2017

6

1 reference

Europe PubMed Central

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15 August 2017

3272-3281

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

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Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation

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Molecular mechanisms of human hemoglobin switching: selective undermethylation and expression of globin genes in embryonic, fetal, and adult erythroblasts

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A novel type of secondary modification of two CCGG residues in the human γδβ-globin gene locus

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30 September 2017

DNA methylation in the human γδβ-globin locus in erythroid and nonerythroid tissues

1 reference

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57 Sequencing end-labeled DNA with base-specific chemical cleavages

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Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia

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30 September 2017

Treatment of sickle cell anemia with 5-azacytidine results in increased fetal hemoglobin production and is associated with nonrandom hypomethylation of DNA around the gamma-delta-beta-globin gene complex

1 reference

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5-Azacytidine stimulates fetal hemoglobin synthesis in anemic baboons

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Short and long range activation by the SV40 enhancer

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The "beta-like-globin" gene domain in human erythroid cells

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Position-independent, high-level expression of the human beta-globin gene in transgenic mice

1 reference

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30 September 2017

Site specific demethylation in the promoter of human gamma-globin gene does not alleviate methylation mediated suppression.

1 reference

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30 September 2017

Human globin gene promoter sequences are sufficient for specific expression of a hybrid gene transfected into tissue culture cells

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30 September 2017

Affinity purification of sequence-specific DNA binding proteins

1 reference

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30 September 2017

Cytosine methylation does not affect binding of transcription factor Sp1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359778

30 September 2017

Cytosine methylation prevents binding to DNA of a HeLa cell transcription factor required for optimal expression of the adenovirus major late promoter

1 reference

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30 September 2017

Erythroid-specific expression of human beta-globin genes in transgenic mice

1 reference

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30 September 2017

CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation

1 reference

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30 September 2017

Increased Sp1 binding mediates erythroid-specific overexpression of a mutated (HPFH) gamma-globulin promoter

1 reference

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30 September 2017

The deletion of the distal CCAAT box region of the A gamma-globin gene in black HPFH abolishes the binding of the erythroid specific protein NFE3 and of the CCAAT displacement protein

1 reference

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30 September 2017

Mutations in two regions upstream of the A gamma globin gene canonical promoter affect gene expression

1 reference

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30 September 2017

Nuclear proteins that bind the human gamma-globin gene promoter: alterations in binding produced by point mutations associated with hereditary persistence of fetal hemoglobin

1 reference

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30 September 2017

Increased gamma-globin expression in a nondeletion HPFH mediated by an erythroid-specific DNA-binding factor

1 reference

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30 September 2017

Interaction of Sp1 with the human gamma globin promoter: binding and transactivation of normal and mutant promoters

1 reference

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30 September 2017

The T→C substitution at -198 of the Aγ-globin gene associated with the British form of HPFH generates overlapping recognition sites for two DNA-binding proteins

1 reference

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Function of normal and mutated gamma-globin gene promoters in electroporated K562 erythroleukemia cells

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A naturally occurring gamma globin gene mutation enhances SP1 binding activity

1 reference

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30 September 2017

Identification of a stage selector element in the human gamma-globin gene promoter that fosters preferential interaction with the 5' HS2 enhancer when in competition with the beta-promoter

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Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA

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An intramolecular DNA triplex is disrupted by point mutations associated with hereditary persistence of fetal hemoglobin

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Therapeutic approaches to hemoglobin switching in treatment of hemoglobinopathies

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Developmental biology of human hemoglobins

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Embryonic epsilon and gamma globin genes of a prosimian primate (Galago crassicaudatus). Nucleotide and amino acid sequences, developmental regulation and phylogenetic footprints.

1 reference

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28 June 2018

Developmental regulation of beta-globin gene switching.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359778

28 June 2018

Requirement of stereospecific alignments for initiation from the simian virus 40 early promoter

1 reference

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Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs

1 reference

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Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice.

1 reference

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Tandem AP-1-binding sites within the human beta-globin dominant control region function as an inducible enhancer in erythroid cells

1 reference

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Importance of globin gene order for correct developmental expression.

1 reference

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Human gamma- to beta-globin gene switching in transgenic mice.

1 reference

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The developmental switch in embryonic rho-globin expression is correlated with erythroid lineage-specific differences in transcription factor levels

1 reference

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Fetal haemoglobin production and the sickle gene in the oases of Eastern Saudi Arabia

1 reference

https://pubmed.ncbi.nlm.nih.gov/7684493

12 December 2020

based on heuristic

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5-Azacytidine Selectively Increases γ-Globin Synthesis in a Patient with β+Thalassemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/7684493

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific expression of a foreign β-globin gene in erythroid cells of transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/7684493

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The beta-globin stage selector element factor is erythroid-specific promoter/enhancer binding protein NF-E4

1 reference

https://pubmed.ncbi.nlm.nih.gov/7684493

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of human globin genes in transgenic mice carrying the beta-globin gene cluster with a mutation causing G gamma beta + hereditary persistence of fetal hemoglobin

1 reference

https://pubmed.ncbi.nlm.nih.gov/7684493

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based on heuristic

inferred from PubMed ID database lookup

DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/7684493

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human γ-globin genes silenced independently of other genes in the β-globin locus

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA methylation: a secondary event in globin gene switching?

1 reference

https://pubmed.ncbi.nlm.nih.gov/7684493

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based on heuristic

inferred from PubMed ID database lookup

Sp1 transcription factor binds DNA and activates transcription even when the binding site is CpG methylated

1 reference

https://pubmed.ncbi.nlm.nih.gov/7684493

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based on heuristic

inferred from PubMed ID database lookup

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

10

1 reference

10.1128/MCB.13.6.3272-3281.1993

https://api.crossref.org/works/10.1128/MCB.13.6.3272-3281.1993

16 August 2024

Identifiers

10.1128/MCB.13.6.3272

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

10.1128/MCB.13.6.3272-3281.1993

1 reference

National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=7684493

16 August 2024

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

ResearchGate publication ID

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