RNA toxicity in polyglutamine disorders: concepts, models, and progress of research (Q36859984)

16 August 2017

2 references

25 April 2019

20 November 2019

RNA toxicity in polyglutamine disorders: concepts, models, and progress of research (English)

1 reference

16 August 2017

1 reference

25 April 2019

1 reference

20 November 2019

Włodzimierz Krzyżosiak

series ordinal

2

object named as

Wlodzimierz J Krzyzosiak

1 reference

16 August 2017

1

Agnieszka Fiszer

1 reference

16 August 2017

20 March 2013

1 reference

PMC publication ID

3659269

Journal of Molecular Medicine

16 August 2017

1 June 2013

2 references

25 April 2019

20 November 2019

3 references

16 August 2017

25 April 2019

20 November 2019

91

1 reference

16 August 2017

6

1 reference

16 August 2017

683-691

1 reference

Creative Commons Attribution-NonCommercial 2.0 Generic

16 August 2017

start time

20 March 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Ubiquitous expression of CUG or CAG trinucleotide repeat RNA causes common morphological defects in a Drosophila model of RNA-mediated pathology

29 September 2017

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Huntingtin protein interactions altered by polyglutamine expansion as determined by quantitative proteomic analysis.

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RNA-binding proteins in microsatellite expansion disorders: mediators of RNA toxicity

29 September 2017

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A pathogenic mechanism in Huntington's disease involves small CAG-repeated RNAs with neurotoxic activity.

29 September 2017

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Polyglutamine neurodegeneration: expanded glutamines enhance native functions

29 September 2017

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Correlation of inter-locus polyglutamine toxicity with CAG•CTG triplet repeat expandability and flanking genomic DNA GC content

29 September 2017

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New function for the RNA helicase p68/DDX5 as a modifier of MBNL1 activity on expanded CUG repeats

29 September 2017

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Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease

29 September 2017

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Genes and pathways affected by CAG-repeat RNA-based toxicity in Drosophila

29 September 2017

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Triplet repeat RNA structure and its role as pathogenic agent and therapeutic target

29 September 2017

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Pathogenic mechanisms in Huntington's disease

29 September 2017

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CAG repeats mimic CUG repeats in the misregulation of alternative splicing

29 September 2017

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Cellular toxicity of expanded RNA repeats: focus on RNA foci

29 September 2017

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Perturbation of U2AF65/NXF1-mediated RNA nuclear export enhances RNA toxicity in polyQ diseases

29 September 2017

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A natural antisense transcript at the Huntington's disease repeat locus regulates HTT expression

29 September 2017

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CAG repeat RNA as an auxiliary toxic agent in polyglutamine disorders

29 September 2017

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Triplet repeat-derived siRNAs enhance RNA-mediated toxicity in a Drosophila model for myotonic dystrophy

29 September 2017

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Long tract of untranslated CAG repeats is deleterious in transgenic mice

29 September 2017

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Mutant CAG repeats of Huntingtin transcript fold into hairpins, form nuclear foci and are targets for RNA interference

29 September 2017

1 reference

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Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions

29 September 2017

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Non-ATG-initiated translation directed by microsatellite expansions

29 September 2017

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Huntington's disease: from molecular pathogenesis to clinical treatment

29 September 2017

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Native Functions of the Androgen Receptor Are Essential to Pathogenesis in a Drosophila Model of Spinobulbar Muscular Atrophy

29 September 2017

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PolyQ Disease: Too Many Qs, Too Much Function?

29 September 2017

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Atomic resolution structure of CAG RNA repeats: structural insights and implications for the trinucleotide repeat expansion diseases

29 September 2017

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Polyglutamine diseases: where does toxicity come from? what is toxicity? where are we going?

29 September 2017

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Roles of trinucleotide-repeat RNA in neurological disease and degeneration.

29 September 2017

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Structural diversity of triplet repeat RNAs

29 September 2017

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RNA gain-of-function in spinocerebellar ataxia type 8.

29 September 2017

1 reference

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Structural insights into CUG repeats containing the 'stretched U-U wobble': implications for myotonic dystrophy

29 September 2017

1 reference

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Post-translational modifications of expanded polyglutamine proteins: impact on neurotoxicity.

29 September 2017

1 reference

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RNA toxicity is a component of ataxin-3 degeneration in Drosophila

29 September 2017

1 reference

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Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1

29 September 2017

1 reference

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Myotonic dystrophy: RNA-mediated muscle disease

29 September 2017

1 reference

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Muscleblind-like 1 interacts with RNA hairpins in splicing target and pathogenic RNAs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659269

DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659269

Trinucleotide Repeat Disorders

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659269

RNA-mediated neuromuscular disorders

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659269

Colocalization of muscleblind with RNA foci is separable from mis-regulation of alternative splicing in myotonic dystrophy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659269

Huntingtin-protein interactions and the pathogenesis of Huntington's disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659269

RNA structure of trinucleotide repeats associated with human neurological diseases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659269

Structures of trinucleotide repeats in human transcripts and their functional implications.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659269

Loss of the muscle-specific chloride channel in type 1 myotonic dystrophy due to misregulated alternative splicing

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659269

RNA CUG repeats sequester CUGBP1 and alter protein levels and activity of CUGBP1

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659269

Recruitment of human muscleblind proteins to (CUG)(n) expansions associated with myotonic dystrophy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659269

Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659269

Disruption of splicing regulated by a CUG-binding protein in myotonic dystrophy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659269

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659269

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659269

Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659269

Absence of disease phenotype and intergenerational stability of the CAG repeat in transgenic mice expressing the human Huntington disease transcript

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659269

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659269

Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659269

Foci of trinucleotide repeat transcripts in nuclei of myotonic dystrophy cells and tissues

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659269

CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659269

Induced pluripotent stem cells from patients with Huntington's disease show CAG-repeat-expansion-associated phenotypes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659269

Marked differences in neurochemistry and aggregates despite similar behavioural and neuropathological features of Huntington disease in the full-length BACHD and YAC128 mice

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659269

Double-stranded RNA is pathogenic in Drosophila models of expanded repeat neurodegenerative diseases

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659269

Huntington's disease--like 2 is associated with CUG repeat-containing RNA foci

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659269

Altered mRNA splicing of the skeletal muscle ryanodine receptor and sarcoplasmic/endoplasmic reticulum Ca2+-ATPase in myotonic dystrophy type 1.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659269

The pathogenic agent in Drosophila models of 'polyglutamine' diseases

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659269

Patterns of CAG repeat interruptions in SCA1 and SCA2 genes in relation to repeat instability

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659269

Molecular architecture of CAG repeats in human disease related transcripts

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659269

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659269

Aberrant regulation of insulin receptor alternative splicing is associated with insulin resistance in myotonic dystrophy

4 September 2018

1 reference

12 December 2020

Misregulation of miR-1 processing is associated with heart defects in myotonic dystrophy

1 reference

12 December 2020

Molecular basis of myotonic dystrophy: expansion of a trinucleotide (CTG) repeat at the 3' end of a transcript encoding a protein kinase family member

1 reference

12 December 2020

Myotonic dystrophy type 1 is associated with nuclear foci of mutant RNA, sequestration of muscleblind proteins and deregulated alternative splicing in neurons

1 reference

12 December 2020

Expression characteristics of triplet repeat-containing RNAs and triplet repeat-interacting proteins in human tissues

1 reference

12 December 2020

Muscleblind participates in RNA toxicity of expanded CAG and CUG repeats in Caenorhabditis elegans

1 reference

12 December 2020

Imperfect CAG repeats form diverse structures in SCA1 transcripts

1 reference

12 December 2020

CUG repeats present in myotonin kinase RNA form metastable "slippery" hairpins

1 reference

12 December 2020

10.1007/S00109-013-1016-2

Identifiers

DOI

1 reference

16 August 2017

1 reference

PMC publication ID

3659269

16 August 2017

PubMed publication ID

23512265

1 reference

PMC publication ID

3659269