Molecular mechanisms of alcohol-mediated carcinogenesis (Q36889966)

16 August 2017

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title

Molecular mechanisms of alcohol-mediated carcinogenesis (English)

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16 August 2017

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Helmut K Seitz

1

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16 August 2017

Felix Stickel

series ordinal

2

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16 August 2017

language of work or name

English

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publication date

1 August 2007

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16 August 2017

published in

Nature Reviews Cancer

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16 August 2017

volume

7

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16 August 2017

issue

8

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16 August 2017

page(s)

599-612

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Carcinogenicity of alcoholic beverages

16 August 2017

cites work

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31 March 2020

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The burden of cancer attributable to alcohol drinking

31 March 2020

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31 March 2020

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Alcohol consumption enhances liver metastasis in colorectal carcinoma patients

31 March 2020

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Ethanol stimulates tumor progression and expression of vascular endothelial growth factor in chick embryos

31 March 2020

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A meta-analysis of alcohol consumption and the risk of 15 diseases

31 March 2020

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Combined effect of tobacco and alcohol on laryngeal cancer risk: a case-control study

31 March 2020

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Alcohol Drinking in Never Users of Tobacco, Cigarette Smoking in Never Drinkers, and the Risk of Head and Neck Cancer: Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium

31 March 2020

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31 March 2020

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Gene-environment interaction between an aldehyde dehydrogenase-2 (ALDH2) polymorphism and alcohol consumption for the risk of esophageal cancer

31 March 2020

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Genetic polymorphisms of alcohol and aldehyde dehydrogenases and risk for esophageal and head and neck cancers

31 March 2020

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Alcohol and hepatocellular carcinoma

31 March 2020

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Case-control study on hepatitis C virus (HCV) as a risk factor for hepatocellular carcinoma: the role of HCV genotypes and the synergism with hepatitis B virus and alcohol. Brescia HCC Study

31 March 2020

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Alcohol consumption as A risk factor for hepatocellular carcinoma in urban Southern African blacks

31 March 2020

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Alcoholic beverage consumption in relation to risk of breast cancer: meta-analysis and review

31 March 2020

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Alcohol, tobacco and breast cancer--collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease

31 March 2020

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Alcohol intake and colorectal cancer: a pooled analysis of 8 cohort studies

31 March 2020

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Alcohol and the risk of cancers of the stomach and colon-rectum

31 March 2020

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Exploring the dose-response relationship between alcohol consumption and the risk of several alcohol-related conditions: a meta-analysis.

31 March 2020

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Effect of ethanol on the tumorigenicity of urethane (ethyl carbamate) in B6C3F1 mice

31 March 2020

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Results of long-term experimental studies on the carcinogenicity of methyl alcohol and ethyl alcohol in rats.

31 March 2020

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Effect of chronic dietary ethanol in the promotion of N-nitrosomethylbenzylamine-induced esophageal carcinogenesis in rats.

31 March 2020

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Enhancing effect of ethanol on esophageal tumor development in rats by initiation of diethylnitrosamine

31 March 2020

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In utero alcohol exposure increases mammary tumorigenesis in rats

31 March 2020

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Possible role of acetaldehyde in ethanol-related rectal cocarcinogenesis in the rat

31 March 2020

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High acetaldehyde levels in saliva after ethanol consumption: methodological aspects and pathogenetic implications.

31 March 2020

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Ethanol, acetaldehyde, acetate, and lactate levels after alcohol intake in white men and women: effect of 4-methylpyrazole

31 March 2020

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High intracolonic acetaldehyde values produced by a bacteriocolonic pathway for ethanol oxidation in piglets

31 March 2020

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In vitro alcohol dehydrogenase-mediated acetaldehyde production by aerobic bacteria representing the normal colonic flora in man.

31 March 2020

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Inhalation toxicity of acetaldehyde in rats. III. Carcinogenicity study

31 March 2020

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Respiratory tract tumours in hamsters exposed to acetaldehyde vapour alone or simultaneously to benzo(a)pyrene or diethylnitrosamine

31 March 2020

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Metabolism of ethanol in vitro produces a compound which induces sister-chromatid exchanges in human peripheral lymphocytes in vitro: acetaldehyde not ethanol is mutagenic

31 March 2020

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A mutagenicity assessment of acetaldehyde

31 March 2020

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Increased frequency of acetaldehyde-induced sister-chromatid exchanges in human lymphocytes treated with an aldehyde dehydrogenase inhibitor

31 March 2020

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Biomarkers to assess the genetic damage induced by alcohol abuse in human lymphocytes

31 March 2020

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Specific tandem GG to TT base substitutions induced by acetaldehyde are due to intra-strand crosslinks between adjacent guanine bases

31 March 2020

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Risk factors and mechanisms of hepatocarcinogenesis with special emphasis on alcohol and oxidative stress

31 March 2020

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The effects of chronic ethanol consumption on carcinogen metabolism and on O6-methylguanine transferase-mediated repair of alkylated DNA.

31 March 2020

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Identification of DNA adducts of acetaldehyde.

31 March 2020

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Identification of an acetaldehyde adduct in human liver DNA and quantitation as N2-ethyldeoxyguanosine

31 March 2020

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Genotoxicity of acetaldehyde- and crotonaldehyde-induced 1,N2-propanodeoxyguanosine DNA adducts in human cells

31 March 2020

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Polyamines stimulate the formation of mutagenic 1,N2-propanodeoxyguanosine adducts from acetaldehyde

31 March 2020

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Detection of DNA adducts of acetaldehyde in peripheral white blood cells of alcohol abusers

31 March 2020

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Development of a 32P-postlabelling method for the analysis of adducts arising through the reaction of acetaldehyde with 2'-deoxyguanosine-3'-monophosphate and DNA.

31 March 2020

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Increased DNA damage in ALDH2-deficient alcoholics.

31 March 2020

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Increased formation of hepatic N2-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde dehydrogenase 2-knockout mice treated with ethanol

31 March 2020

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Esophageal epithelial hyperproliferation following long-term alcohol consumption in rats: effects of age and salivary gland function

31 March 2020

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Increased rectal cell proliferation following alcohol abuse

31 March 2020

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Enhancement of ethanol induced rectal mucosal hyper regeneration with age in F344 rats

31 March 2020

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Effects of acetaldehyde on cell regeneration and differentiation of the upper gastrointestinal tract mucosa

31 March 2020

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Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology

31 March 2020

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Evidence for an Important Role of Alcohol- and Aldehyde-Metabolizing Genes in Cancers of the Upper Aerodigestive Tract

31 March 2020

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Effects of ALDH2 gene polymorphisms and alcohol-drinking behavior on micronuclei frequency in non-smokers

31 March 2020

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Linkage disequilibrium at the ADH2 and ADH3 loci and risk of alcoholism

31 March 2020

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Alcohol dehydrogenase 3 genotype and risk of oral cavity and pharyngeal cancers

31 March 2020

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Laryngeal and oropharyngeal cancer, and alcohol dehydrogenase 3 and glutathione S-transferase M1 polymorphisms

31 March 2020

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Risk of head and neck cancer and the alcohol dehydrogenase 3 genotype

31 March 2020

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Interaction between a single nucleotide polymorphism in the alcohol dehydrogenase 3 gene, alcohol consumption and oral cancer risk

31 March 2020

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Laryngeal cancer risk in Caucasians is associated with alcohol and tobacco consumption but not modified by genetic polymorphisms in class I alcohol dehydrogenases ADH1B and ADH1C, and glutathione-S-transferases GSTM1 and GSTT1.

31 March 2020

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Alcohol dehydrogenase 3 and risk of squamous cell carcinomas of the head and neck

31 March 2020

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Alcohol dehydrogenase 3 genotype as a risk factor for upper aerodigestive tract cancers

31 March 2020

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The ADH1C polymorphism modifies the risk of squamous cell carcinoma of the head and neck associated with alcohol and tobacco use

31 March 2020

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Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: a HuGE review

31 March 2020

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Increased cancer risk in heavy drinkers with the alcohol dehydrogenase 1C*1 allele, possibly due to salivary acetaldehyde

31 March 2020

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Alcohol dehydrogenase 1C*1 allele is a genetic marker for alcohol-associated cancer in heavy drinkers

31 March 2020

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ADH3 genotype, alcohol intake and breast cancer risk

31 March 2020

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Alcohol dehydrogenase 3 genotype modification of the association of alcohol consumption with breast cancer risk

31 March 2020

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Alcohol and breast cancer: review of epidemiologic and experimental evidence and potential mechanisms

31 March 2020

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31 March 2020

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Increased salivary acetaldehyde levels in heavy drinkers and smokers: a microbiological approach to oral cavity cancer.

31 March 2020

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Poor dental status increases acetaldehyde production from ethanol in saliva: a possible link to increased oral cancer risk among heavy drinkers

31 March 2020

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Increased acetaldehyde production by mouthwashings from patients with oral cavity, laryngeal, or pharyngeal cancer

31 March 2020

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Synergistic effect of alcohol drinking and smoking on in vivo acetaldehyde concentration in saliva

31 March 2020

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Inhibition of intracolonic acetaldehyde production and alcoholic fermentation in rats by ciprofloxacin

31 March 2020

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Alcohol, oxidative stress and free radical damage

31 March 2020

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Contribution of mitochondria to oxidative stress associated with alcoholic liver disease

31 March 2020

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Neutrophilic infiltration in alcoholic hepatitis

31 March 2020

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Nitric oxide and liver injury in alcohol-fed rats after lipopolysaccharide administration

31 March 2020

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Phase I/II enzyme gene polymorphisms and esophageal cancer risk: a meta-analysis of the literature

31 March 2020

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Genetic polymorphisms of cytochrome p4502E1 and susceptibility to alcoholic liver disease and hepatocellular carcinoma in a white population: a study and literature review, including meta-analysis.

31 March 2020

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Dynamics of cytochrome P4502E1 activity in man: induction by ethanol and disappearance during withdrawal phase

31 March 2020

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Inhibition of ethanol-induced liver disease in the intragastric feeding rat model by chlormethiazole

31 March 2020

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Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol-induced oxidative DNA damage in rodent liver

31 March 2020

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Production of a cytochrome P450 2E1 transgenic mouse and initial evaluation of alcoholic liver damage

31 March 2020

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Increased circulating products of lipid peroxidation in patients with alcoholic liver disease.

31 March 2020

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Formation of 1,N6-ethenoadenine and 3,N4-ethenocytosine by lipid peroxidation products and nucleic acid bases

31 March 2020

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The major lipid peroxidation product, trans-4-hydroxy-2-nonenal, preferentially forms DNA adducts at codon 249 of human p53 gene, a unique mutational hotspot in hepatocellular carcinoma

31 March 2020

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Immunohistochemical detection of 1,N6-ethenodeoxyadenosine in nuclei of human liver affected by diseases predisposing to hepato-carcinogenesis

31 March 2020

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Immunohistochemical localization of ethanol-inducible P450IIE1 in the rat alimentary tract

31 March 2020

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Cocarcinogenic effects of alcohol in hepatocarcinogenesis

31 March 2020

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Characterization of ethanol's enhancement of tumorigenesis by N-nitrosodimethylamine in mice

31 March 2020

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Early hepatocellular carcinoma and dysplastic nodules

31 March 2020

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Ethanol interactions with a choline-deficient, ethionine-supplemented feeding regime potentiate pre-neoplastic cellular alterations in rat liver

31 March 2020

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Appearance of oval cells in the liver of rats after long-term exposure to ethanol

31 March 2020

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Progenitor cells in diseased human liver

31 March 2020

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A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells

31 March 2020

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Cytokines in alcoholic and nonalcoholic steatohepatitis

31 March 2020

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Chronic ethanol-mediated decrease in cAMP primes macrophages to enhanced LPS-inducible NF-kappaB activity and TNF expression: relevance to alcoholic liver disease

31 March 2020

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NF-kappaB functions as a tumour promoter in inflammation-associated cancer

31 March 2020

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IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis

31 March 2020

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Mechanisms of alcohol-induced hepatic fibrosis: a summary of the Ron Thurman Symposium

31 March 2020

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Transforming growth factor-beta differentially regulates oval cell and hepatocyte proliferation

31 March 2020

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TGF-beta signaling: positive and negative effects on tumorigenesis

31 March 2020

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TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis

31 March 2020

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Is mallory body formation a preneoplastic change? A study of 181 cases of liver bearing hepatocellular carcinoma and 82 cases of cirrhosis

31 March 2020

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Mallory body forming cells express the preneoplastic hepatocyte phenotype

31 March 2020

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Hepatic vitamin A depletion in alcoholic liver injury

31 March 2020

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Alcohol, vitamin A, and cancer

31 March 2020

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Ethanol enhances retinoic acid metabolism into polar metabolites in rat liver via induction of cytochrome P4502E1.

31 March 2020

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Chronic alcohol intake reduces retinoic acid concentration and enhances AP-1 (c-Jun and c-Fos) expression in rat liver

31 March 2020

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Presence of benzo[a]pyrene diol epoxide adducts in target DNA leads to an increase in UV-induced DNA single strand breaks and supF gene mutations

31 March 2020

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Chlormethiazole treatment prevents reduced hepatic vitamin A levels in ethanol-fed rats

31 March 2020

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Alpha-Tocopherol and beta-carotene supplements and lung cancer incidence in the alpha-tocopherol, beta-carotene cancer prevention study: effects of base-line characteristics and study compliance

31 March 2020

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Hepatotoxicity of alcohol-induced polar retinol metabolites involves apoptosis via loss of mitochondrial membrane potential.

31 March 2020

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DNA methylation and gene silencing in cancer

31 March 2020

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How does DNA methylation repress transcription?

31 March 2020

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Creation of genomic methylation patterns

31 March 2020

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Liver-specific methionine adenosyltransferase MAT1A gene expression is associated with a specific pattern of promoter methylation and histone acetylation: implications for MAT1A silencing during transformation.

31 March 2020

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Molecular profiling of hepatocellular carcinoma in mice with a chronic deficiency of hepatic s-adenosylmethionine: relevance in human liver diseases

31 March 2020

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Ethanol consumption inhibits fetal DNA methylation in mice: implications for the fetal alcohol syndrome

31 March 2020

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Chronic alcohol consumption induces genomic but not p53-specific DNA hypomethylation in rat colon.

31 March 2020

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Alcohol, low-methionine--low-folate diets, and risk of colon cancer in men

31 March 2020

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Vitamin B6 intake, alcohol consumption, and colorectal cancer: a longitudinal population-based cohort of women

31 March 2020

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Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review

31 March 2020

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European Code Against Cancer and scientific justification: third version (2003).

31 March 2020

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IL-6 inhibits apoptosis and retains oxidative DNA lesions in human gastric cancer AGS cells through up-regulation of anti-apoptotic gene mcl-1.

31 March 2020

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Increased cytogenetic damage detected by FISH analysis on micronuclei in peripheral lymphocytes from alcoholics

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Direct interaction of GD3 ganglioside with mitochondria generates reactive oxygen species followed by mitochondrial permeability transition, cytochrome c release, and caspase activation

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRC2191

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16 August 2017

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