Digitoxin as an anticancer agent with selectivity for cancer cells: possible mechanisms involved (Q36897343)

16 August 2017

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title

Digitoxin as an anticancer agent with selectivity for cancer cells: possible mechanisms involved (English)

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16 August 2017

Miguel López-Lázaro

1

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16 August 2017

language of work or name

English

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publication date

1 August 2007

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Expert Opinion on Therapeutic Targets

16 August 2017

published in

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16 August 2017

volume

11

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16 August 2017

issue

8

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16 August 2017

page(s)

1043-1053

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The use of digitalis in heart failure

16 August 2017

cites work

1 reference

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Positive inotropic effect of ouabain on isolated heart is accompanied by activation of signal pathways that link Na+/K+-ATPase to ERK1/2.

21 January 2018

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Cellular basis for the species differences in sensitivity to cardiac glycosides (digitalis).

21 January 2018

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Interspecies differences in cancer susceptibility and toxicity

21 January 2018

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Digitoxin medication and cancer; case control and internal dose-response studies

21 January 2018

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Cytotoxicity of digitoxin and related cardiac glycosides in human tumor cells

21 January 2018

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Inhibitory effects of digitalis on the proliferation of androgen dependent and independent prostate cancer cells

21 January 2018

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Anti-tumour activity of Digitalis purpurea L. subsp. heywoodii.

21 January 2018

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Digitalis-induced signaling by Na+/K+-ATPase in human breast cancer cells.

21 January 2018

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Na/K-ATPase, endogenous digitalis like compounds and cancer development -- a hypothesis

21 January 2018

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Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients

21 January 2018

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Cardiac glycosides inhibit TNF-alpha/NF-kappaB signaling by blocking recruitment of TNF receptor-associated death domain to the TNF receptor

21 January 2018

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Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization

21 January 2018

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Sodium/potassium ATPase (Na+, K+-ATPase) and ouabain/related cardiac glycosides: A new paradigm for development of anti- breast cancer drugs?

21 January 2018

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Cardiac glycosides initiate Apo2L/TRAIL-induced apoptosis in non-small cell lung cancer cells by up-regulation of death receptors 4 and 5.

21 January 2018

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Involvement of Cdk5/p25 in digoxin-triggered prostate cancer cell apoptosis.

21 January 2018

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Oleandrin-mediated expression of Fas potentiates apoptosis in tumor cells

21 January 2018

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Inhibition of export of fibroblast growth factor-2 (FGF-2) from the prostate cancer cell lines PC3 and DU145 by Anvirzel and its cardiac glycoside component, oleandrin

21 January 2018

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Oleandrin suppresses activation of nuclear transcription factor-κB and activator protein-1 and potentiates apoptosis induced by ceramide

21 January 2018

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Investigation of ouabain-induced anticancer effect in human androgen-independent prostate cancer PC-3 cells.

21 January 2018

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The cardenolide UNBS1450 is able to deactivate nuclear factor kappaB-mediated cytoprotective effects in human non-small cell lung cancer cells

21 January 2018

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Cardiac glycoside induces cell death via FasL by activating calcineurin and NF-AT, but apoptosis initially proceeds through activation of caspases

21 January 2018

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Oleandrin induces apoptosis in human, but not in murine cells: dephosphorylation of Akt, expression of FasL, and alteration of membrane fluidity

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

The sodium pump. Its molecular properties and mechanics of ion transport

21 January 2018

1 reference

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Regulation and critical role of potassium homeostasis in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

The role of apoptotic volume decrease and ionic homeostasis in the activation and repression of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Na+, K+-ATPase: the new face of an old player in pathogenesis and apoptotic/hybrid cell death

21 January 2018

1 reference

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Apoptotic volume decrease and the incredible shrinking cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Uncoupling cell shrinkage from apoptosis reveals that Na+ influx is required for volume loss during programmed cell death

21 January 2018

1 reference

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On the mechanism of ionic regulation of apoptosis: would the Na+/K+-ATPase please stand up?

21 January 2018

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Regulation of cell death: the calcium-apoptosis link

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Why do cancers have high aerobic glycolysis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

MRI of the tumor microenvironment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Intracellular pH is increased after transformation of Chinese hamster embryo fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Increased pH and tumorigenicity of fibroblasts expressing a yeast proton pump.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Na+/H+ exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Intracellular acidification triggered by mitochondrial-derived hydrogen peroxide is an effector mechanism for drug-induced apoptosis in tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Amiloride potentiates TRAIL-induced tumor cell apoptosis by intracellular acidification-dependent Akt inactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Alterations of intracellular pH homeostasis in apoptosis: origins and roles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Apoptosis induced in Jurkat cells by several agents is preceded by intracellular acidification

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Mitochondria-dependent apoptosis and cellular pH regulation

21 January 2018

1 reference

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Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Interleukin-8 and human cancer biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

The role of interleukin-8 in cancer cells and microenvironment interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Digitoxin mimics gene therapy with CFTR and suppresses hypersecretion of IL-8 from cystic fibrosis lung epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

NF-kappaB at the crossroads of life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Nuclear factor-kappaB in cancer development and progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Topoisomerase II as a target for anticancer drugs: when enzymes stop being nice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Apoptosis induced by topoisomerase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Digitoxin, at concentrations commonly found in the plasma of cardiac patients, antagonizes etoposide and idarubicin activity in K562 leukemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Inhibition of DNA topoisomerases I and II, and growth inhibition of breast cancer MCF-7 cells by ouabain, digoxin and proscillaridin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Dual role of hydrogen peroxide in cancer: possible relevance to cancer chemoprevention and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

On the Origin of Cancer Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Proteomic changes in renal cancer and co-ordinate demonstration of both the glycolytic and mitochondrial aspects of the Warburg effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Glycolysis inhibition for anticancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Targeting HIF-1 for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Hypoxia-inducible factor 1 as a possible target for cancer chemoprevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Mitochondrial O2*- and H2O2 mediate glucose deprivation-induced stress in human cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Glucose withdrawal induces oxidative stress followed by apoptosis in glioblastoma cells but not in normal human astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Acid-mediated tumor invasion: a multidisciplinary study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

The bioenergetic signature of lung adenocarcinomas is a molecular marker of cancer diagnosis and prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Breast carcinomas fulfill the Warburg hypothesis and provide metabolic markers of cancer prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

p53 regulates mitochondrial respiration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Superoxide and hydrogen peroxide in relation to mammalian cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Reactive oxygen generated by Nox1 triggers the angiogenic switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Excessive superoxide anion generation plays a key role in carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Hydrogen peroxide-mediated cytosolic acidification is a signal for mitochondrial translocation of Bax during drug-induced apoptosis of tumor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Hydrogen peroxide-induced renal injury. A protective role for pyruvate in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Pyruvate secreted by human lymphoid cell lines protects cells from hydrogen peroxide mediated cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Controlled elimination of intracellular H(2)O(2): regulation of peroxiredoxin, catalase, and glutathione peroxidase via post-translational modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Linkage of aerobic glycolysis to sodium-potassium transport in rat skeletal muscle. Implications for increased muscle lactate production in sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Curing metastatic cancer: lessons from testicular germ-cell tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Will the dark sky over advanced renal cell carcinoma soon become brighter?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

Increased nuclear factor-kappa B activation is related to the tumor development of renal cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.8.1043

10.1517/14728222.11.8.1043

21 January 2018

Identifiers

DOI

1 reference

16 August 2017

1 reference