The novel Chk1 inhibitor MK-8776 sensitizes human leukemia cells to HDAC inhibitors by targeting the intra-S checkpoint and DNA replication and repair (Q36927012)

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scientific article published on 27 March 2013

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English	The novel Chk1 inhibitor MK-8776 sensitizes human leukemia cells to HDAC inhibitors by targeting the intra-S checkpoint and DNA replication and repair	scientific article published on 27 March 2013

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

The novel Chk1 inhibitor MK-8776 sensitizes human leukemia cells to HDAC inhibitors by targeting the intra-S checkpoint and DNA replication and repair (English)

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

author name string

Yun Dai

1

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Shuang Chen

2

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Maciej Kmieciak

3

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Liang Zhou

4

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Hui Lin

5

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Xin-Yan Pei

6

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Steven Grant

7

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

publication date

27 March 2013

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Molecular Cancer Therapeutics

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

12

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

6

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

878-889

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Effects of selective checkpoint kinase 1 inhibition on cytarabine cytotoxicity in acute myelogenous leukemia cells in vitro

1 reference

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Sensitization of pancreatic cancer stem cells to gemcitabine by Chk1 inhibition

1 reference

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Human embryonic stem cells fail to activate CHK1 and commit to apoptosis in response to DNA replication stress

1 reference

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Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models.

1 reference

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Evaluation of checkpoint kinase targeting therapy in acute myeloid leukemia with complex karyotype

1 reference

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29 September 2017

Preclinical development of the novel Chk1 inhibitor SCH900776 in combination with DNA-damaging agents and antimetabolites

1 reference

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HDAC inhibitors in cancer biology: emerging mechanisms and clinical applications

1 reference

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Therapeutic targeting of Chk1 in NSCLC stem cells during chemotherapy.

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Role of checkpoint kinase 1 (Chk1) in the mechanisms of resistance to histone deacetylase inhibitors

1 reference

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Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication

1 reference

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Cytokinetically quiescent (G0/G1) human multiple myeloma cells are susceptible to simultaneous inhibition of Chk1 and MEK1/2.

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Analysis of individual molecular events of DNA damage response by flow- and image-assisted cytometry

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Bortezomib interacts synergistically with belinostat in human acute myeloid leukaemia and acute lymphoblastic leukaemia cells in association with perturbations in NF-κB and Bim

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29 September 2017

Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening

1 reference

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29 September 2017

Histone deacetylase inhibitors downregulate checkpoint kinase 1 expression to induce cell death in non-small cell lung cancer cells

1 reference

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Cells expressing FLT3/ITD mutations exhibit elevated repair errors generated through alternative NHEJ pathways: implications for genomic instability and therapy

1 reference

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Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair.

1 reference

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Downregulation of homologous recombination DNA repair genes by HDAC inhibition in prostate cancer is mediated through the E2F1 transcription factor

1 reference

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Inhibition of histone deacetylase in cancer cells slows down replication forks, activates dormant origins, and induces DNA damage

1 reference

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DNA damage and decisions: CtIP coordinates DNA repair and cell cycle checkpoints

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In vitro and in vivo radiation sensitization of human tumor cells by a novel checkpoint kinase inhibitor, AZD7762.

1 reference

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29 September 2017

New insights into checkpoint kinase 1 in the DNA damage response signaling network

1 reference

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29 September 2017

CtIP links DNA double-strand break sensing to resection

1 reference

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The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress

1 reference

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CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle.

1 reference

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Cdt1 and Cdc6 are destabilized by rereplication-induced DNA damage.

1 reference

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Essential role of Chk1 in S phase progression through regulation of RNR2 expression

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A chemical method for fast and sensitive detection of DNA synthesis in vivo

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Genetics of therapy-related myelodysplasia and acute myeloid leukemia

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1 reference

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Conservative homologous recombination preferentially repairs DNA double-strand breaks in the S phase of the cell cycle in human cells

1 reference

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FLT3 mutations in acute myeloid leukemia cell lines

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Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing

1 reference

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The dual PI3 kinase/mTOR inhibitor PI-103 prevents p53 induction by Mdm2 inhibition but enhances p53-mediated mitochondrial apoptosis in p53 wild-type AML.

1 reference

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Histone deacetylase inhibitors (HDI) cause DNA damage in leukemia cells: a mechanism for leukemia-specific HDI-dependent apoptosis?

1 reference

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The onset of p53-dependent DNA repair or apoptosis is determined by the level of accumulated damaged DNA.

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A functional wild-type p53 gene is expressed in human acute myeloid leukemia cell lines.

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Detection of p53 gene mutations by single strand conformational polymorphism (SSCP) in human acute myeloid leukemia-derived cell lines

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Frequent mutations in the p53 gene in human myeloid leukemia cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/23536721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/1535-7163.MCT-12-0902

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

ResearchGate publication ID

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